EHS1_SCHPO
ID EHS1_SCHPO Reviewed; 486 AA.
AC Q10063;
DT 01-FEB-1996, integrated into UniProtKB/Swiss-Prot.
DT 01-FEB-1996, sequence version 1.
DT 25-MAY-2022, entry version 130.
DE RecName: Full=Calcium influx-promoting protein ehs1;
DE Flags: Precursor;
GN Name=ehs1; Synonyms=yam8; ORFNames=SPAC1F5.08c;
OS Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Taphrinomycotina;
OC Schizosaccharomycetes; Schizosaccharomycetales; Schizosaccharomycetaceae;
OC Schizosaccharomyces.
OX NCBI_TaxID=284812;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA], AND FUNCTION.
RX PubMed=10694511; DOI=10.1006/bbrc.2000.2278;
RA Tasaka Y., Nakagawa Y., Sato C., Mino M., Uozumi N., Murata N., Muto S.,
RA Iida H.;
RT "yam8(+), a Schizosaccharomyces pombe gene, is a potential homologue of the
RT Saccharomyces cerevisiae MID1 gene encoding a stretch-activated Ca(2+)-
RT permeable channel.";
RL Biochem. Biophys. Res. Commun. 269:265-269(2000).
RN [2]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA], AND FUNCTION.
RX PubMed=11016847; DOI=10.1007/s004380000318;
RA Carnero E., Ribas J.C., Garcia B., Duran A., Sanchez Y.;
RT "Schizosaccharomyces pombe ehs1p is involved in maintaining cell wall
RT integrity and in calcium uptake.";
RL Mol. Gen. Genet. 264:173-183(2000).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=972 / ATCC 24843;
RX PubMed=11859360; DOI=10.1038/nature724;
RA Wood V., Gwilliam R., Rajandream M.A., Lyne M.H., Lyne R., Stewart A.,
RA Sgouros J.G., Peat N., Hayles J., Baker S.G., Basham D., Bowman S.,
RA Brooks K., Brown D., Brown S., Chillingworth T., Churcher C.M., Collins M.,
RA Connor R., Cronin A., Davis P., Feltwell T., Fraser A., Gentles S.,
RA Goble A., Hamlin N., Harris D.E., Hidalgo J., Hodgson G., Holroyd S.,
RA Hornsby T., Howarth S., Huckle E.J., Hunt S., Jagels K., James K.D.,
RA Jones L., Jones M., Leather S., McDonald S., McLean J., Mooney P.,
RA Moule S., Mungall K.L., Murphy L.D., Niblett D., Odell C., Oliver K.,
RA O'Neil S., Pearson D., Quail M.A., Rabbinowitsch E., Rutherford K.M.,
RA Rutter S., Saunders D., Seeger K., Sharp S., Skelton J., Simmonds M.N.,
RA Squares R., Squares S., Stevens K., Taylor K., Taylor R.G., Tivey A.,
RA Walsh S.V., Warren T., Whitehead S., Woodward J.R., Volckaert G., Aert R.,
RA Robben J., Grymonprez B., Weltjens I., Vanstreels E., Rieger M.,
RA Schaefer M., Mueller-Auer S., Gabel C., Fuchs M., Duesterhoeft A.,
RA Fritzc C., Holzer E., Moestl D., Hilbert H., Borzym K., Langer I., Beck A.,
RA Lehrach H., Reinhardt R., Pohl T.M., Eger P., Zimmermann W., Wedler H.,
RA Wambutt R., Purnelle B., Goffeau A., Cadieu E., Dreano S., Gloux S.,
RA Lelaure V., Mottier S., Galibert F., Aves S.J., Xiang Z., Hunt C.,
RA Moore K., Hurst S.M., Lucas M., Rochet M., Gaillardin C., Tallada V.A.,
RA Garzon A., Thode G., Daga R.R., Cruzado L., Jimenez J., Sanchez M.,
RA del Rey F., Benito J., Dominguez A., Revuelta J.L., Moreno S.,
RA Armstrong J., Forsburg S.L., Cerutti L., Lowe T., McCombie W.R.,
RA Paulsen I., Potashkin J., Shpakovski G.V., Ussery D., Barrell B.G.,
RA Nurse P.;
RT "The genome sequence of Schizosaccharomyces pombe.";
RL Nature 415:871-880(2002).
CC -!- FUNCTION: Required for Ca(2+) influx and for vitality of cells in a
CC late, pheromone-induced event of the mating process requiring calcium-
CC induced signaling. {ECO:0000269|PubMed:10694511,
CC ECO:0000269|PubMed:11016847}.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Single-pass membrane
CC protein {ECO:0000305}.
CC -!- SIMILARITY: To yeast MID1. {ECO:0000305}.
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DR EMBL; CU329670; CAA92236.1; -; Genomic_DNA.
DR PIR; JC7212; JC7212.
DR PIR; T38087; T38087.
DR RefSeq; NP_592865.1; NM_001018265.2.
DR AlphaFoldDB; Q10063; -.
DR BioGRID; 278123; 43.
DR STRING; 4896.SPAC1F5.08c.1; -.
DR TCDB; 8.A.41.1.7; the stretch-activated calcium channel auxiliary protein, mid1 (mid1) family.
DR MaxQB; Q10063; -.
DR PaxDb; Q10063; -.
DR EnsemblFungi; SPAC1F5.08c.1; SPAC1F5.08c.1:pep; SPAC1F5.08c.
DR GeneID; 2541627; -.
DR KEGG; spo:SPAC1F5.08c; -.
DR PomBase; SPAC1F5.08c; -.
DR VEuPathDB; FungiDB:SPAC1F5.08c; -.
DR eggNOG; ENOG502QTEW; Eukaryota.
DR HOGENOM; CLU_018731_0_0_1; -.
DR InParanoid; Q10063; -.
DR OMA; PFAKEQF; -.
DR PhylomeDB; Q10063; -.
DR PRO; PR:Q10063; -.
DR Proteomes; UP000002485; Chromosome I.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0016020; C:membrane; IDA:PomBase.
DR GO; GO:0005886; C:plasma membrane; IGI:PomBase.
DR GO; GO:0005262; F:calcium channel activity; IMP:PomBase.
DR GO; GO:0098703; P:calcium ion import across plasma membrane; IMP:PomBase.
DR InterPro; IPR024338; Mid1/Ehs1.
DR Pfam; PF12929; Mid1; 1.
PE 3: Inferred from homology;
KW Calcium; Glycoprotein; Membrane; Reference proteome; Signal; Transmembrane;
KW Transmembrane helix.
FT SIGNAL 1..24
FT /evidence="ECO:0000255"
FT CHAIN 25..486
FT /note="Calcium influx-promoting protein ehs1"
FT /id="PRO_0000021160"
FT TOPO_DOM 25..464
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 465..485
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 486
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT CARBOHYD 33
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 49
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 59
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 82
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 93
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
SQ SEQUENCE 486 AA; 53888 MW; 3B2C4173E60089E8 CRC64;
MFFFSTHLIL KILFFWSITR NIFGATYTSL LLNNTINGNI NDQSTAYYNL TWEGNTAYNV
SLTLSTCTAF DGANDLMLYI SNNTFDEALP LDNFTITASE NGLATIFVTG YSPLYIAVSS
AFSQFAPNFF VESGESTLEG NNVINYELAA GIDTPFSQYN ATKFLFAQDT DFQAALLITG
NLTTNETSII PSYEIYVNPS NSTYDNTFNK FSSSFCAFQN NPSTVNTNNA DRSMTLRGLG
PFAKEQFYLK GLDPNVTYTA YLVEPNIGQP GGTVYPGVTF TTKTSPACQL IYDLQFCSEV
AYAVPGNSSL FSASALAEWY DQQAYGYYQN FTYTLDLIPC NATSWSAYSL LKNCSDCANS
YKNWLCASVI PRCADINDNS SYLIYKNYDS RYPLIDEVIQ PGPYKEVLPC SYLCYSLASS
CPLDLGFACP KAGYGLEFSY GEVSNVTGLI TCNAPGVEFY ESGSALLNIS WRTFFISLIF
WILFVE
