ID   EI24_DICDI              Reviewed;         307 AA.
AC   Q54PW9;
DT   29-APR-2008, integrated into UniProtKB/Swiss-Prot.
DT   24-MAY-2005, sequence version 1.
DT   25-MAY-2022, entry version 72.
DE   RecName: Full=Protein EI24 homolog;
GN   ORFNames=DDB_G0284253;
OS   Dictyostelium discoideum (Slime mold).
OC   Eukaryota; Amoebozoa; Evosea; Eumycetozoa; Dictyostelia; Dictyosteliales;
OC   Dictyosteliaceae; Dictyostelium.
OX   NCBI_TaxID=44689;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=AX4;
RX   PubMed=15875012; DOI=10.1038/nature03481;
RA   Eichinger L., Pachebat J.A., Gloeckner G., Rajandream M.A., Sucgang R.,
RA   Berriman M., Song J., Olsen R., Szafranski K., Xu Q., Tunggal B.,
RA   Kummerfeld S., Madera M., Konfortov B.A., Rivero F., Bankier A.T.,
RA   Lehmann R., Hamlin N., Davies R., Gaudet P., Fey P., Pilcher K., Chen G.,
RA   Saunders D., Sodergren E.J., Davis P., Kerhornou A., Nie X., Hall N.,
RA   Anjard C., Hemphill L., Bason N., Farbrother P., Desany B., Just E.,
RA   Morio T., Rost R., Churcher C.M., Cooper J., Haydock S., van Driessche N.,
RA   Cronin A., Goodhead I., Muzny D.M., Mourier T., Pain A., Lu M., Harper D.,
RA   Lindsay R., Hauser H., James K.D., Quiles M., Madan Babu M., Saito T.,
RA   Buchrieser C., Wardroper A., Felder M., Thangavelu M., Johnson D.,
RA   Knights A., Loulseged H., Mungall K.L., Oliver K., Price C., Quail M.A.,
RA   Urushihara H., Hernandez J., Rabbinowitsch E., Steffen D., Sanders M.,
RA   Ma J., Kohara Y., Sharp S., Simmonds M.N., Spiegler S., Tivey A.,
RA   Sugano S., White B., Walker D., Woodward J.R., Winckler T., Tanaka Y.,
RA   Shaulsky G., Schleicher M., Weinstock G.M., Rosenthal A., Cox E.C.,
RA   Chisholm R.L., Gibbs R.A., Loomis W.F., Platzer M., Kay R.R.,
RA   Williams J.G., Dear P.H., Noegel A.A., Barrell B.G., Kuspa A.;
RT   "The genome of the social amoeba Dictyostelium discoideum.";
RL   Nature 435:43-57(2005).
CC   -!- SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Multi-pass membrane
CC       protein {ECO:0000305}.
CC   -!- SIMILARITY: Belongs to the EI24 family. {ECO:0000305}.
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DR   EMBL; AAFI02000064; EAL65315.1; -; Genomic_DNA.
DR   RefSeq; XP_638676.1; XM_633584.1.
DR   AlphaFoldDB; Q54PW9; -.
DR   STRING; 44689.DDB0185926; -.
DR   PaxDb; Q54PW9; -.
DR   EnsemblProtists; EAL65315; EAL65315; DDB_G0284253.
DR   GeneID; 8624505; -.
DR   KEGG; ddi:DDB_G0284253; -.
DR   dictyBase; DDB_G0284253; ei24.
DR   eggNOG; KOG3966; Eukaryota.
DR   HOGENOM; CLU_031164_1_1_1; -.
DR   InParanoid; Q54PW9; -.
DR   OMA; AEQYNHI; -.
DR   PhylomeDB; Q54PW9; -.
DR   PRO; PR:Q54PW9; -.
DR   Proteomes; UP000002195; Chromosome 4.
DR   GO; GO:0005783; C:endoplasmic reticulum; IDA:dictyBase.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0006974; P:cellular response to DNA damage stimulus; IMP:dictyBase.
DR   GO; GO:0016236; P:macroautophagy; IBA:GO_Central.
DR   GO; GO:0010629; P:negative regulation of gene expression; IMP:dictyBase.
DR   GO; GO:0010628; P:positive regulation of gene expression; IMP:dictyBase.
DR   InterPro; IPR009890; EI24.
DR   PANTHER; PTHR21389; PTHR21389; 1.
PE   3: Inferred from homology;
KW   Glycoprotein; Membrane; Reference proteome; Transmembrane;
KW   Transmembrane helix.
FT   CHAIN           1..307
FT                   /note="Protein EI24 homolog"
FT                   /id="PRO_0000331479"
FT   TRANSMEM        53..73
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        92..112
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        153..173
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        175..195
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        225..245
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        260..280
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        135
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   307 AA;  35933 MW;  F3A5C8160545FF8B CRC64;
     METFKEYVTK RIDNTIPQVK EMFKLIWLGV ADSMKLKGAI IRTIKSEVLR KNFIHCIFLN
     GIIFLGTYLI YLYWVSPMLN YLLNHFPTLS NMFTIIYFSL WVYPVYIFSI IANSKWYTEI
     AKESFVISGR TTFANSTNGI LSSFVDEIYR NLLFGVILVM SAIIAFIPYT NFINFVIITW
     LYSFWCFDYK WILRGKWNLL QRIQYFETHW AYMFGYGLIF TTCSFFFPML IGNAIFSILY
     PLFIILSISA KPTKMVNQDG ILPKQIPIFY VPEIIVNVIL KLYVKYKNTR GAAKSTTPSP
     SPTTKQN