ID   EI2BA_BOVIN             Reviewed;         305 AA.
AC   Q0IIF2;
DT   03-APR-2007, integrated into UniProtKB/Swiss-Prot.
DT   03-OCT-2006, sequence version 1.
DT   03-AUG-2022, entry version 84.
DE   RecName: Full=Translation initiation factor eIF-2B subunit alpha;
DE   AltName: Full=eIF-2B GDP-GTP exchange factor subunit alpha;
GN   Name=EIF2B1;
OS   Bos taurus (Bovine).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
OC   Bovinae; Bos.
OX   NCBI_TaxID=9913;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   STRAIN=Hereford; TISSUE=Fetal muscle;
RG   NIH - Mammalian Gene Collection (MGC) project;
RL   Submitted (AUG-2006) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Catalyzes the exchange of eukaryotic initiation factor 2-
CC       bound GDP for GTP. {ECO:0000250}.
CC   -!- SUBUNIT: Complex of five different subunits; alpha, beta, gamma, delta
CC       and epsilon. {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the eIF-2B alpha/beta/delta subunits family.
CC       {ECO:0000305}.
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DR   EMBL; BC122673; AAI22674.1; -; mRNA.
DR   RefSeq; NP_001069211.1; NM_001075743.1.
DR   AlphaFoldDB; Q0IIF2; -.
DR   SMR; Q0IIF2; -.
DR   STRING; 9913.ENSBTAP00000009560; -.
DR   PaxDb; Q0IIF2; -.
DR   PRIDE; Q0IIF2; -.
DR   Ensembl; ENSBTAT00000009560; ENSBTAP00000009560; ENSBTAG00000007269.
DR   GeneID; 516670; -.
DR   KEGG; bta:516670; -.
DR   CTD; 1967; -.
DR   VEuPathDB; HostDB:ENSBTAG00000007269; -.
DR   VGNC; VGNC:28384; EIF2B1.
DR   eggNOG; KOG1466; Eukaryota.
DR   GeneTree; ENSGT00550000074853; -.
DR   HOGENOM; CLU_016218_0_2_1; -.
DR   InParanoid; Q0IIF2; -.
DR   OMA; LYPLGQY; -.
DR   OrthoDB; 865202at2759; -.
DR   TreeFam; TF101505; -.
DR   Proteomes; UP000009136; Chromosome 17.
DR   Bgee; ENSBTAG00000007269; Expressed in oocyte and 103 other tissues.
DR   GO; GO:0005851; C:eukaryotic translation initiation factor 2B complex; IBA:GO_Central.
DR   GO; GO:0005886; C:plasma membrane; IEA:Ensembl.
DR   GO; GO:0005085; F:guanyl-nucleotide exchange factor activity; IEA:Ensembl.
DR   GO; GO:0042802; F:identical protein binding; IEA:Ensembl.
DR   GO; GO:0003743; F:translation initiation factor activity; IEA:UniProtKB-KW.
DR   GO; GO:0014003; P:oligodendrocyte development; IEA:Ensembl.
DR   GO; GO:0050852; P:T cell receptor signaling pathway; IEA:Ensembl.
DR   GO; GO:0006413; P:translational initiation; IBA:GO_Central.
DR   Gene3D; 1.20.120.1070; -; 1.
DR   Gene3D; 3.40.50.10470; -; 1.
DR   InterPro; IPR042528; elF-2B_alpha_N.
DR   InterPro; IPR000649; IF-2B-related.
DR   InterPro; IPR042529; IF_2B-like_C.
DR   InterPro; IPR037171; NagB/RpiA_transferase-like.
DR   Pfam; PF01008; IF-2B; 1.
DR   SUPFAM; SSF100950; SSF100950; 1.
PE   2: Evidence at transcript level;
KW   Initiation factor; Protein biosynthesis; Reference proteome.
FT   CHAIN           1..305
FT                   /note="Translation initiation factor eIF-2B subunit alpha"
FT                   /id="PRO_0000283062"
SQ   SEQUENCE   305 AA;  33870 MW;  22FFC8682F72CB55 CRC64;
     MDNTELIEYF KSQIKEDPDM ASAVAAIRTL LEYLRRDTGE TIQGLRANLT SAIETLCGVD
     SSVAVSSGGE LFLRFISLTS LEYSDYSKCK KIMIERGEIF LRRISLSRNK IADLCHTFIK
     DGARILTHAY SRVVLRVLEA AVAAKKRFSV YITESQPDLS GKKMAKALCH LNVPVTVVLD
     AAVGYIMEKV DLVIVGAEGV VENGGIINKI GTNQMAVCAK AQNKPFYVVA ESFKFVRLFP
     LNQQDVPDKF KYKADTLKSV QTGQDLREEH PWVDYTSPSL ITLLFTDLGV LTPSAVSDEL
     IKLYL