ID   EI2BA_CAEEL             Reviewed;         305 AA.
AC   P34604;
DT   01-FEB-1994, integrated into UniProtKB/Swiss-Prot.
DT   01-FEB-1994, sequence version 1.
DT   03-AUG-2022, entry version 137.
DE   RecName: Full=Probable translation initiation factor eIF-2B subunit alpha;
DE   AltName: Full=eIF-2B GDP-GTP exchange factor subunit alpha;
GN   ORFNames=ZK1098.4;
OS   Caenorhabditis elegans.
OC   Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC   Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae;
OC   Caenorhabditis.
OX   NCBI_TaxID=6239;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Bristol N2;
RX   PubMed=7906398; DOI=10.1038/368032a0;
RA   Wilson R., Ainscough R., Anderson K., Baynes C., Berks M., Bonfield J.,
RA   Burton J., Connell M., Copsey T., Cooper J., Coulson A., Craxton M.,
RA   Dear S., Du Z., Durbin R., Favello A., Fraser A., Fulton L., Gardner A.,
RA   Green P., Hawkins T., Hillier L., Jier M., Johnston L., Jones M.,
RA   Kershaw J., Kirsten J., Laisster N., Latreille P., Lightning J., Lloyd C.,
RA   Mortimore B., O'Callaghan M., Parsons J., Percy C., Rifken L., Roopra A.,
RA   Saunders D., Shownkeen R., Sims M., Smaldon N., Smith A., Smith M.,
RA   Sonnhammer E., Staden R., Sulston J., Thierry-Mieg J., Thomas K.,
RA   Vaudin M., Vaughan K., Waterston R., Watson A., Weinstock L.,
RA   Wilkinson-Sproat J., Wohldman P.;
RT   "2.2 Mb of contiguous nucleotide sequence from chromosome III of C.
RT   elegans.";
RL   Nature 368:32-38(1994).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Bristol N2;
RX   PubMed=9851916; DOI=10.1126/science.282.5396.2012;
RG   The C. elegans sequencing consortium;
RT   "Genome sequence of the nematode C. elegans: a platform for investigating
RT   biology.";
RL   Science 282:2012-2018(1998).
CC   -!- FUNCTION: Catalyzes the exchange of eukaryotic initiation factor 2-
CC       bound GDP for GTP.
CC   -!- SUBUNIT: Complex of five different subunits; alpha, beta, gamma, delta
CC       and epsilon.
CC   -!- INTERACTION:
CC       P34604; P34604: ZK1098.4; NbExp=3; IntAct=EBI-313831, EBI-313831;
CC   -!- SIMILARITY: Belongs to the eIF-2B alpha/beta/delta subunits family.
CC       {ECO:0000305}.
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DR   EMBL; Z22176; CAA80132.1; -; Genomic_DNA.
DR   PIR; S40927; S40927.
DR   RefSeq; NP_499106.1; NM_066705.4.
DR   AlphaFoldDB; P34604; -.
DR   SMR; P34604; -.
DR   BioGRID; 41543; 30.
DR   DIP; DIP-26550N; -.
DR   IntAct; P34604; 20.
DR   STRING; 6239.ZK1098.4; -.
DR   EPD; P34604; -.
DR   PaxDb; P34604; -.
DR   PeptideAtlas; P34604; -.
DR   EnsemblMetazoa; ZK1098.4.1; ZK1098.4.1; WBGene00014221.
DR   GeneID; 176348; -.
DR   KEGG; cel:CELE_ZK1098.4; -.
DR   UCSC; ZK1098.4; c. elegans.
DR   CTD; 176348; -.
DR   WormBase; ZK1098.4; CE00367; WBGene00014221; -.
DR   eggNOG; KOG1466; Eukaryota.
DR   GeneTree; ENSGT00550000074853; -.
DR   HOGENOM; CLU_016218_0_2_1; -.
DR   InParanoid; P34604; -.
DR   OMA; LYPLGQY; -.
DR   OrthoDB; 865202at2759; -.
DR   PhylomeDB; P34604; -.
DR   Reactome; R-CEL-72731; Recycling of eIF2:GDP.
DR   PRO; PR:P34604; -.
DR   Proteomes; UP000001940; Chromosome III.
DR   Bgee; WBGene00014221; Expressed in germ line (C elegans) and 4 other tissues.
DR   GO; GO:0005851; C:eukaryotic translation initiation factor 2B complex; IBA:GO_Central.
DR   GO; GO:0042802; F:identical protein binding; IPI:IntAct.
DR   GO; GO:0003743; F:translation initiation factor activity; IEA:UniProtKB-KW.
DR   GO; GO:0050790; P:regulation of catalytic activity; IEA:GOC.
DR   GO; GO:0006413; P:translational initiation; IBA:GO_Central.
DR   Gene3D; 1.20.120.1070; -; 1.
DR   Gene3D; 3.40.50.10470; -; 1.
DR   InterPro; IPR042528; elF-2B_alpha_N.
DR   InterPro; IPR000649; IF-2B-related.
DR   InterPro; IPR042529; IF_2B-like_C.
DR   InterPro; IPR037171; NagB/RpiA_transferase-like.
DR   Pfam; PF01008; IF-2B; 1.
DR   SUPFAM; SSF100950; SSF100950; 1.
PE   1: Evidence at protein level;
KW   Initiation factor; Protein biosynthesis; Reference proteome.
FT   CHAIN           1..305
FT                   /note="Probable translation initiation factor eIF-2B
FT                   subunit alpha"
FT                   /id="PRO_0000156058"
SQ   SEQUENCE   305 AA;  34117 MW;  4040328A3828116B CRC64;
     MVQESIISSF RGKLENDPSK STSLATVETL LEVLDRSRAT TVAEFQNELN QVVAALEKTD
     YSSTSIRSAA DLFTRFTSLA PAALLDQEDF SQVLDLYRQR ARSFIKNVRG SRAKISKCAR
     LFFTHHMNIL THSYSKVVLE TILDAHKSGY HLHVWVTESQ PDASGKLVFE ELKKNGVPTT
     LVLDSCVGYV MERIQAVLVG AEGVMETGGI INKIGTVNVC IIAKSRHVPV YVCAETIKFV
     REFPLNQADI PQEFKYRTSV IERNNLELEH PDVDYTAPEF LTLIITDVGA MKPEAVGEEL
     IKMYI