ID   EI2BA_DICDI             Reviewed;         321 AA.
AC   Q54I81;
DT   08-APR-2008, integrated into UniProtKB/Swiss-Prot.
DT   24-MAY-2005, sequence version 1.
DT   25-MAY-2022, entry version 92.
DE   RecName: Full=Translation initiation factor eIF-2B subunit alpha;
DE   AltName: Full=eIF-2B GDP-GTP exchange factor subunit alpha;
GN   Name=eif2b1; ORFNames=DDB_G0288961;
OS   Dictyostelium discoideum (Slime mold).
OC   Eukaryota; Amoebozoa; Evosea; Eumycetozoa; Dictyostelia; Dictyosteliales;
OC   Dictyosteliaceae; Dictyostelium.
OX   NCBI_TaxID=44689;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=AX4;
RX   PubMed=15875012; DOI=10.1038/nature03481;
RA   Eichinger L., Pachebat J.A., Gloeckner G., Rajandream M.A., Sucgang R.,
RA   Berriman M., Song J., Olsen R., Szafranski K., Xu Q., Tunggal B.,
RA   Kummerfeld S., Madera M., Konfortov B.A., Rivero F., Bankier A.T.,
RA   Lehmann R., Hamlin N., Davies R., Gaudet P., Fey P., Pilcher K., Chen G.,
RA   Saunders D., Sodergren E.J., Davis P., Kerhornou A., Nie X., Hall N.,
RA   Anjard C., Hemphill L., Bason N., Farbrother P., Desany B., Just E.,
RA   Morio T., Rost R., Churcher C.M., Cooper J., Haydock S., van Driessche N.,
RA   Cronin A., Goodhead I., Muzny D.M., Mourier T., Pain A., Lu M., Harper D.,
RA   Lindsay R., Hauser H., James K.D., Quiles M., Madan Babu M., Saito T.,
RA   Buchrieser C., Wardroper A., Felder M., Thangavelu M., Johnson D.,
RA   Knights A., Loulseged H., Mungall K.L., Oliver K., Price C., Quail M.A.,
RA   Urushihara H., Hernandez J., Rabbinowitsch E., Steffen D., Sanders M.,
RA   Ma J., Kohara Y., Sharp S., Simmonds M.N., Spiegler S., Tivey A.,
RA   Sugano S., White B., Walker D., Woodward J.R., Winckler T., Tanaka Y.,
RA   Shaulsky G., Schleicher M., Weinstock G.M., Rosenthal A., Cox E.C.,
RA   Chisholm R.L., Gibbs R.A., Loomis W.F., Platzer M., Kay R.R.,
RA   Williams J.G., Dear P.H., Noegel A.A., Barrell B.G., Kuspa A.;
RT   "The genome of the social amoeba Dictyostelium discoideum.";
RL   Nature 435:43-57(2005).
CC   -!- FUNCTION: Catalyzes the exchange of eukaryotic initiation factor 2-
CC       bound GDP for GTP. {ECO:0000250}.
CC   -!- SUBUNIT: Complex of five different subunits; alpha, beta, gamma, delta
CC       and epsilon. {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the eIF-2B alpha/beta/delta subunits family.
CC       {ECO:0000305}.
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DR   EMBL; AAFI02000126; EAL63004.1; -; Genomic_DNA.
DR   RefSeq; XP_636498.1; XM_631406.1.
DR   AlphaFoldDB; Q54I81; -.
DR   SMR; Q54I81; -.
DR   STRING; 44689.DDB0231375; -.
DR   PaxDb; Q54I81; -.
DR   PRIDE; Q54I81; -.
DR   EnsemblProtists; EAL63004; EAL63004; DDB_G0288961.
DR   GeneID; 8626881; -.
DR   KEGG; ddi:DDB_G0288961; -.
DR   dictyBase; DDB_G0288961; eif2b1.
DR   eggNOG; KOG1466; Eukaryota.
DR   HOGENOM; CLU_016218_0_2_1; -.
DR   InParanoid; Q54I81; -.
DR   OMA; LYPLGQY; -.
DR   PhylomeDB; Q54I81; -.
DR   Reactome; R-DDI-72731; Recycling of eIF2:GDP.
DR   PRO; PR:Q54I81; -.
DR   Proteomes; UP000002195; Chromosome 5.
DR   GO; GO:0005851; C:eukaryotic translation initiation factor 2B complex; ISS:UniProtKB.
DR   GO; GO:0003743; F:translation initiation factor activity; IEA:UniProtKB-KW.
DR   GO; GO:0050790; P:regulation of catalytic activity; IEA:GOC.
DR   GO; GO:0006413; P:translational initiation; ISS:UniProtKB.
DR   Gene3D; 1.20.120.1070; -; 1.
DR   Gene3D; 3.40.50.10470; -; 1.
DR   InterPro; IPR042528; elF-2B_alpha_N.
DR   InterPro; IPR000649; IF-2B-related.
DR   InterPro; IPR042529; IF_2B-like_C.
DR   InterPro; IPR037171; NagB/RpiA_transferase-like.
DR   Pfam; PF01008; IF-2B; 1.
DR   SUPFAM; SSF100950; SSF100950; 1.
PE   3: Inferred from homology;
KW   Initiation factor; Protein biosynthesis; Reference proteome.
FT   CHAIN           1..321
FT                   /note="Translation initiation factor eIF-2B subunit alpha"
FT                   /id="PRO_0000327988"
SQ   SEQUENCE   321 AA;  35645 MW;  5DD01D717BAB7FE7 CRC64;
     MTGGLNKDFD WVVAKFEEMI KRETEVSIAI PTIRILIDVI RKSNSTTVVG LQKELEDAVK
     QLKSCPYNQS ISLSSVCDSF IRFVTKRTEL DFPNFDTCKS NLVERGEQLS NKSSMSRTKI
     SQLADKFIRD GVTILVHGFS RVVLGLLLHA AFQGKRFSVI VTESRPDSSG YKTAARLQAA
     NIPVKLIMDG GVSRIIDKVD YVLVGAEAIV ENGGIVNKIG TYQISIVAKA FKKPFYVAAE
     SFKFTRSYPL NQSDIENLKN DHISEPFKAC RSCSSCENPE QLTIDSPTLD YTPPSYITLL
     FTELGVLTPS AVSDELIKLY C