EI2BA_MOUSE
ID EI2BA_MOUSE Reviewed; 305 AA.
AC Q99LC8;
DT 12-FEB-2003, integrated into UniProtKB/Swiss-Prot.
DT 01-JUN-2001, sequence version 1.
DT 03-AUG-2022, entry version 136.
DE RecName: Full=Translation initiation factor eIF-2B subunit alpha;
DE AltName: Full=eIF-2B GDP-GTP exchange factor subunit alpha;
GN Name=Eif2b1;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [2]
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC TISSUE=Brain, Heart, Kidney, Liver, Lung, Pancreas, Spleen, and Testis;
RX PubMed=21183079; DOI=10.1016/j.cell.2010.12.001;
RA Huttlin E.L., Jedrychowski M.P., Elias J.E., Goswami T., Rad R.,
RA Beausoleil S.A., Villen J., Haas W., Sowa M.E., Gygi S.P.;
RT "A tissue-specific atlas of mouse protein phosphorylation and expression.";
RL Cell 143:1174-1189(2010).
CC -!- FUNCTION: Catalyzes the exchange of eukaryotic initiation factor 2-
CC bound GDP for GTP.
CC -!- SUBUNIT: Complex of five different subunits; alpha, beta, gamma, delta
CC and epsilon.
CC -!- SIMILARITY: Belongs to the eIF-2B alpha/beta/delta subunits family.
CC {ECO:0000305}.
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DR EMBL; BC003426; AAH03426.1; -; mRNA.
DR CCDS; CCDS39282.1; -.
DR RefSeq; NP_663346.1; NM_145371.4.
DR AlphaFoldDB; Q99LC8; -.
DR SMR; Q99LC8; -.
DR BioGRID; 229070; 3.
DR IntAct; Q99LC8; 1.
DR STRING; 10090.ENSMUSP00000031334; -.
DR iPTMnet; Q99LC8; -.
DR PhosphoSitePlus; Q99LC8; -.
DR EPD; Q99LC8; -.
DR MaxQB; Q99LC8; -.
DR PaxDb; Q99LC8; -.
DR PRIDE; Q99LC8; -.
DR ProteomicsDB; 277576; -.
DR Antibodypedia; 31819; 160 antibodies from 26 providers.
DR Ensembl; ENSMUST00000031334; ENSMUSP00000031334; ENSMUSG00000029388.
DR GeneID; 209354; -.
DR KEGG; mmu:209354; -.
DR UCSC; uc008zqd.1; mouse.
DR CTD; 1967; -.
DR MGI; MGI:2384802; Eif2b1.
DR VEuPathDB; HostDB:ENSMUSG00000029388; -.
DR eggNOG; KOG1466; Eukaryota.
DR GeneTree; ENSGT00550000074853; -.
DR HOGENOM; CLU_016218_0_2_1; -.
DR InParanoid; Q99LC8; -.
DR OMA; LYPLGQY; -.
DR OrthoDB; 865202at2759; -.
DR PhylomeDB; Q99LC8; -.
DR TreeFam; TF101505; -.
DR Reactome; R-MMU-72731; Recycling of eIF2:GDP.
DR BioGRID-ORCS; 209354; 25 hits in 72 CRISPR screens.
DR ChiTaRS; Eif2b1; mouse.
DR PRO; PR:Q99LC8; -.
DR Proteomes; UP000000589; Chromosome 5.
DR RNAct; Q99LC8; protein.
DR Bgee; ENSMUSG00000029388; Expressed in animal zygote and 282 other tissues.
DR ExpressionAtlas; Q99LC8; baseline and differential.
DR Genevisible; Q99LC8; MM.
DR GO; GO:0005737; C:cytoplasm; ISS:UniProtKB.
DR GO; GO:0005850; C:eukaryotic translation initiation factor 2 complex; ISO:MGI.
DR GO; GO:0005851; C:eukaryotic translation initiation factor 2B complex; ISS:UniProtKB.
DR GO; GO:0016020; C:membrane; ISO:MGI.
DR GO; GO:0005886; C:plasma membrane; ISO:MGI.
DR GO; GO:0019003; F:GDP binding; ISO:MGI.
DR GO; GO:0005525; F:GTP binding; ISO:MGI.
DR GO; GO:0005085; F:guanyl-nucleotide exchange factor activity; ISO:MGI.
DR GO; GO:0042802; F:identical protein binding; ISO:MGI.
DR GO; GO:0003743; F:translation initiation factor activity; ISO:MGI.
DR GO; GO:1905098; P:negative regulation of guanyl-nucleotide exchange factor activity; ISO:MGI.
DR GO; GO:0014003; P:oligodendrocyte development; ISS:UniProtKB.
DR GO; GO:1990928; P:response to amino acid starvation; ISO:MGI.
DR GO; GO:0009749; P:response to glucose; ISO:MGI.
DR GO; GO:0009408; P:response to heat; ISO:MGI.
DR GO; GO:0043434; P:response to peptide hormone; ISO:MGI.
DR GO; GO:0050852; P:T cell receptor signaling pathway; ISS:UniProtKB.
DR GO; GO:0006412; P:translation; ISO:MGI.
DR GO; GO:0006413; P:translational initiation; ISS:UniProtKB.
DR Gene3D; 1.20.120.1070; -; 1.
DR Gene3D; 3.40.50.10470; -; 1.
DR InterPro; IPR042528; elF-2B_alpha_N.
DR InterPro; IPR000649; IF-2B-related.
DR InterPro; IPR042529; IF_2B-like_C.
DR InterPro; IPR037171; NagB/RpiA_transferase-like.
DR Pfam; PF01008; IF-2B; 1.
DR SUPFAM; SSF100950; SSF100950; 1.
PE 1: Evidence at protein level;
KW Acetylation; Initiation factor; Protein biosynthesis; Reference proteome.
FT CHAIN 1..305
FT /note="Translation initiation factor eIF-2B subunit alpha"
FT /id="PRO_0000156056"
FT MOD_RES 35
FT /note="N6-acetyllysine"
FT /evidence="ECO:0000250|UniProtKB:Q14232"
SQ SEQUENCE 305 AA; 33816 MW; 9D9ED81F0D9B8411 CRC64;
MEDGELIEYF KSQMKGDPKM ASAVAAIQTL LEFLKRDKGE TLQGLRANLT YAIKTLCGVD
SSVAVSSGGE LFLRFISLTS LEYSDYSKCK KIMIERGELF LRRISLSRNK IANLCHTFIK
DGARILTHAY SRVVLRVLEE AVAAKKRFSV YITESQPDLS GKKMAKALSH LNVPVTVVLD
AAVGYIMEKA DLVIVGAEGV VENGGIINKI GTNQMAVCAK AQNKPFYVVA ESFKFVRLFP
LNQEDVPDKF KYKADTLKSV QTGQDLKEEH PWVDYTSPSL ITLLFTDLGV LTPSAVSDEL
IKLYL
