ID   EI2BA_PONAB             Reviewed;         305 AA.
AC   Q5RAR0;
DT   17-APR-2007, integrated into UniProtKB/Swiss-Prot.
DT   17-APR-2007, sequence version 2.
DT   25-MAY-2022, entry version 77.
DE   RecName: Full=Translation initiation factor eIF-2B subunit alpha;
DE   AltName: Full=eIF-2B GDP-GTP exchange factor subunit alpha;
GN   Name=EIF2B1;
OS   Pongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC   Pongo.
OX   NCBI_TaxID=9601;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Kidney;
RG   The German cDNA consortium;
RL   Submitted (NOV-2004) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Catalyzes the exchange of eukaryotic initiation factor 2-
CC       bound GDP for GTP. {ECO:0000250}.
CC   -!- SUBUNIT: Complex of five different subunits; alpha, beta, gamma, delta
CC       and epsilon. {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the eIF-2B alpha/beta/delta subunits family.
CC       {ECO:0000305}.
CC   -!- SEQUENCE CAUTION:
CC       Sequence=CAH91150.1; Type=Erroneous initiation; Evidence={ECO:0000305};
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DR   EMBL; CR858952; CAH91150.1; ALT_INIT; mRNA.
DR   RefSeq; NP_001125672.1; NM_001132200.2.
DR   RefSeq; XP_009246655.1; XM_009248380.1.
DR   RefSeq; XP_009246656.1; XM_009248381.1.
DR   RefSeq; XP_009246657.1; XM_009248382.1.
DR   AlphaFoldDB; Q5RAR0; -.
DR   SMR; Q5RAR0; -.
DR   STRING; 9601.ENSPPYP00000005799; -.
DR   Ensembl; ENSPPYT00000052695; ENSPPYP00000039427; ENSPPYG00000005092.
DR   GeneID; 100172592; -.
DR   KEGG; pon:100172592; -.
DR   CTD; 1967; -.
DR   eggNOG; KOG1466; Eukaryota.
DR   GeneTree; ENSGT00550000074853; -.
DR   HOGENOM; CLU_016218_0_2_1; -.
DR   InParanoid; Q5RAR0; -.
DR   OMA; LYPLGQY; -.
DR   OrthoDB; 865202at2759; -.
DR   TreeFam; TF101505; -.
DR   Proteomes; UP000001595; Chromosome 12.
DR   GO; GO:0003743; F:translation initiation factor activity; IEA:UniProtKB-KW.
DR   Gene3D; 1.20.120.1070; -; 1.
DR   Gene3D; 3.40.50.10470; -; 1.
DR   InterPro; IPR042528; elF-2B_alpha_N.
DR   InterPro; IPR000649; IF-2B-related.
DR   InterPro; IPR042529; IF_2B-like_C.
DR   InterPro; IPR037171; NagB/RpiA_transferase-like.
DR   Pfam; PF01008; IF-2B; 1.
DR   SUPFAM; SSF100950; SSF100950; 1.
PE   2: Evidence at transcript level;
KW   Acetylation; Initiation factor; Protein biosynthesis; Reference proteome.
FT   CHAIN           1..305
FT                   /note="Translation initiation factor eIF-2B subunit alpha"
FT                   /id="PRO_0000284611"
FT   MOD_RES         35
FT                   /note="N6-acetyllysine"
FT                   /evidence="ECO:0000250|UniProtKB:Q14232"
SQ   SEQUENCE   305 AA;  33712 MW;  91A915FF1B80B780 CRC64;
     MDDKELIEYF KSQMKEDPDM ASAVAAIRTL LEFLKRDKGE TIQGLRANLT SAIETLCGVD
     SSVAVSSGGE LFLRFISLAS LEYSDYSKCK KIMIERGELF LRRISLSRNK IADLCHTFIK
     DGATILTHAY SRVVLRVLEA AVAAKKRFSV YVTESQPDLS GKKMAKALCH LNVPVTVVLD
     AAVGYIMEKA DLVIVGAEGV VENGGIINKI GTNQMAVCAK AQNKPFYVVA ESFKFVRLFP
     LNQQDVPDKF KYKADTLKVA QTGQDLKEEH PWVDYTAPSL ITLLFTDLGV LTPSAVSDEL
     IKLYL