EI2BA_RAT
ID EI2BA_RAT Reviewed; 305 AA.
AC Q64270;
DT 01-NOV-1997, integrated into UniProtKB/Swiss-Prot.
DT 01-NOV-1997, sequence version 1.
DT 03-AUG-2022, entry version 120.
DE RecName: Full=Translation initiation factor eIF-2B subunit alpha;
DE AltName: Full=eIF-2B GDP-GTP exchange factor subunit alpha;
GN Name=Eif2b1; Synonyms=Eif2ba;
OS Rattus norvegicus (Rat).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Rattus.
OX NCBI_TaxID=10116;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA].
RC STRAIN=Sprague-Dawley; TISSUE=Brain;
RX PubMed=7753796; DOI=10.1073/pnas.92.10.4274;
RA Flowers K.M., Kimball S.R., Feldhoff R.C., Hinnebusch A.G., Jefferson L.S.;
RT "Molecular cloning and characterization of cDNA encoding the alpha subunit
RT of the rat protein synthesis initiation factor eIF-2B.";
RL Proc. Natl. Acad. Sci. U.S.A. 92:4274-4278(1995).
RN [2]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX PubMed=7495858; DOI=10.1016/0167-4781(95)00160-i;
RA Flowers K.M., Mellor H., Kimball S.R., Jefferson L.S.;
RT "Structure and sequence of the gene encoding the alpha-subunit of rat
RT translation initiation factor-2B.";
RL Biochim. Biophys. Acta 1264:163-167(1995).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Testis;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
CC -!- FUNCTION: Catalyzes the exchange of eukaryotic initiation factor 2-
CC bound GDP for GTP.
CC -!- SUBUNIT: Complex of five different subunits; alpha, beta, gamma, delta
CC and epsilon.
CC -!- SIMILARITY: Belongs to the eIF-2B alpha/beta/delta subunits family.
CC {ECO:0000305}.
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DR EMBL; U05821; AAC52196.1; -; mRNA.
DR EMBL; L41679; AAA91276.1; -; Genomic_DNA.
DR EMBL; BC081709; AAH81709.1; -; mRNA.
DR PIR; I59376; I59376.
DR RefSeq; NP_742026.1; NM_172029.2.
DR AlphaFoldDB; Q64270; -.
DR SMR; Q64270; -.
DR STRING; 10116.ENSRNOP00000001373; -.
DR PhosphoSitePlus; Q64270; -.
DR jPOST; Q64270; -.
DR PaxDb; Q64270; -.
DR PRIDE; Q64270; -.
DR GeneID; 64514; -.
DR KEGG; rno:64514; -.
DR UCSC; RGD:620819; rat.
DR CTD; 1967; -.
DR RGD; 620819; Eif2b1.
DR eggNOG; KOG1466; Eukaryota.
DR HOGENOM; CLU_016218_0_2_1; -.
DR InParanoid; Q64270; -.
DR OrthoDB; 865202at2759; -.
DR PhylomeDB; Q64270; -.
DR TreeFam; TF101505; -.
DR Reactome; R-RNO-72731; Recycling of eIF2:GDP.
DR PRO; PR:Q64270; -.
DR Proteomes; UP000002494; Chromosome 12.
DR Bgee; ENSRNOG00000001039; Expressed in pancreas and 20 other tissues.
DR ExpressionAtlas; Q64270; baseline and differential.
DR Genevisible; Q64270; RN.
DR GO; GO:0005737; C:cytoplasm; ISS:UniProtKB.
DR GO; GO:0005850; C:eukaryotic translation initiation factor 2 complex; IDA:RGD.
DR GO; GO:0005851; C:eukaryotic translation initiation factor 2B complex; IDA:RGD.
DR GO; GO:0016020; C:membrane; ISO:RGD.
DR GO; GO:0005886; C:plasma membrane; ISO:RGD.
DR GO; GO:0019003; F:GDP binding; IDA:RGD.
DR GO; GO:0005525; F:GTP binding; IMP:RGD.
DR GO; GO:0042802; F:identical protein binding; ISO:RGD.
DR GO; GO:0003743; F:translation initiation factor activity; IDA:RGD.
DR GO; GO:1905098; P:negative regulation of guanyl-nucleotide exchange factor activity; IDA:RGD.
DR GO; GO:0014003; P:oligodendrocyte development; ISS:UniProtKB.
DR GO; GO:1990928; P:response to amino acid starvation; IDA:RGD.
DR GO; GO:0009749; P:response to glucose; IDA:UniProtKB.
DR GO; GO:0009408; P:response to heat; IDA:UniProtKB.
DR GO; GO:0043434; P:response to peptide hormone; IDA:UniProtKB.
DR GO; GO:0050852; P:T cell receptor signaling pathway; ISS:UniProtKB.
DR GO; GO:0006412; P:translation; IDA:RGD.
DR GO; GO:0006413; P:translational initiation; IDA:RGD.
DR Gene3D; 1.20.120.1070; -; 1.
DR Gene3D; 3.40.50.10470; -; 1.
DR InterPro; IPR042528; elF-2B_alpha_N.
DR InterPro; IPR000649; IF-2B-related.
DR InterPro; IPR042529; IF_2B-like_C.
DR InterPro; IPR037171; NagB/RpiA_transferase-like.
DR Pfam; PF01008; IF-2B; 1.
DR SUPFAM; SSF100950; SSF100950; 1.
PE 2: Evidence at transcript level;
KW Acetylation; Initiation factor; Protein biosynthesis; Reference proteome.
FT CHAIN 1..305
FT /note="Translation initiation factor eIF-2B subunit alpha"
FT /id="PRO_0000156057"
FT MOD_RES 35
FT /note="N6-acetyllysine"
FT /evidence="ECO:0000250|UniProtKB:Q14232"
SQ SEQUENCE 305 AA; 33678 MW; E0ACC1756E118101 CRC64;
MEDGELIKYF KSQMKGDPNM ASAVAAIQTL LEFLKRDKGE TIQGLRAHLT KAIETLCAVD
SSVAVSSGGE LFLRFISLTS LEYSDYSKCK KIMIERGELF LSRISLSRTK IASLCHAFIK
DGARILTHAY SRVVLRVLEE AVAAKKRFSV YITESQPDLS GKKMAKALCH LNVPVTVVLD
AAVGYIMEKV DLVIVGAEGV VENGGIINKI GTNQMAVCAK AQNKPFYVVA ESFKFVRLFP
LNQQDVPDKF KYKADTLKSV QAGQDLKEEH PWVDYTSPSL ITLLFTDLGV LTPSAVSDEL
IKLYL
