ID   EI2BB_BOVIN             Reviewed;         351 AA.
AC   Q5E9B4; A4FV73;
DT   21-FEB-2006, integrated into UniProtKB/Swiss-Prot.
DT   15-MAR-2005, sequence version 1.
DT   03-AUG-2022, entry version 88.
DE   RecName: Full=Translation initiation factor eIF-2B subunit beta;
DE   AltName: Full=eIF-2B GDP-GTP exchange factor subunit beta;
GN   Name=EIF2B2;
OS   Bos taurus (Bovine).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
OC   Bovinae; Bos.
OX   NCBI_TaxID=9913;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RX   PubMed=16305752; DOI=10.1186/1471-2164-6-166;
RA   Harhay G.P., Sonstegard T.S., Keele J.W., Heaton M.P., Clawson M.L.,
RA   Snelling W.M., Wiedmann R.T., Van Tassell C.P., Smith T.P.L.;
RT   "Characterization of 954 bovine full-CDS cDNA sequences.";
RL   BMC Genomics 6:166-166(2005).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   STRAIN=Hereford; TISSUE=Brain cortex;
RG   NIH - Mammalian Gene Collection (MGC) project;
RL   Submitted (SEP-2006) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Catalyzes the exchange of eukaryotic initiation factor 2-
CC       bound GDP for GTP. {ECO:0000250}.
CC   -!- SUBUNIT: Complex of five different subunits; alpha, beta, gamma, delta
CC       and epsilon. {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the eIF-2B alpha/beta/delta subunits family.
CC       {ECO:0000305}.
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DR   EMBL; BT021006; AAX09023.1; -; mRNA.
DR   EMBL; BC123823; AAI23824.1; -; mRNA.
DR   RefSeq; NP_001015593.1; NM_001015593.1.
DR   AlphaFoldDB; Q5E9B4; -.
DR   SMR; Q5E9B4; -.
DR   STRING; 9913.ENSBTAP00000011424; -.
DR   PaxDb; Q5E9B4; -.
DR   PRIDE; Q5E9B4; -.
DR   Ensembl; ENSBTAT00000011424; ENSBTAP00000011424; ENSBTAG00000008664.
DR   GeneID; 513958; -.
DR   KEGG; bta:513958; -.
DR   CTD; 8892; -.
DR   VEuPathDB; HostDB:ENSBTAG00000008664; -.
DR   VGNC; VGNC:28385; EIF2B2.
DR   eggNOG; KOG1465; Eukaryota.
DR   GeneTree; ENSGT00550000074908; -.
DR   HOGENOM; CLU_016218_4_3_1; -.
DR   InParanoid; Q5E9B4; -.
DR   OMA; TSHTSYA; -.
DR   OrthoDB; 918011at2759; -.
DR   TreeFam; TF101506; -.
DR   Proteomes; UP000009136; Chromosome 10.
DR   Bgee; ENSBTAG00000008664; Expressed in prostate gland and 108 other tissues.
DR   GO; GO:0005737; C:cytoplasm; ISS:UniProtKB.
DR   GO; GO:0005851; C:eukaryotic translation initiation factor 2B complex; ISS:UniProtKB.
DR   GO; GO:0005524; F:ATP binding; ISS:UniProtKB.
DR   GO; GO:0005525; F:GTP binding; ISS:UniProtKB.
DR   GO; GO:0005085; F:guanyl-nucleotide exchange factor activity; IEA:Ensembl.
DR   GO; GO:0003743; F:translation initiation factor activity; IBA:GO_Central.
DR   GO; GO:0007417; P:central nervous system development; ISS:UniProtKB.
DR   GO; GO:0042552; P:myelination; ISS:UniProtKB.
DR   GO; GO:0014003; P:oligodendrocyte development; ISS:UniProtKB.
DR   GO; GO:0001541; P:ovarian follicle development; ISS:UniProtKB.
DR   GO; GO:0050852; P:T cell receptor signaling pathway; ISS:UniProtKB.
DR   GO; GO:0006413; P:translational initiation; ISS:UniProtKB.
DR   Gene3D; 3.40.50.10470; -; 1.
DR   InterPro; IPR000649; IF-2B-related.
DR   InterPro; IPR042529; IF_2B-like_C.
DR   InterPro; IPR037171; NagB/RpiA_transferase-like.
DR   Pfam; PF01008; IF-2B; 1.
DR   SUPFAM; SSF100950; SSF100950; 1.
PE   2: Evidence at transcript level;
KW   Initiation factor; Protein biosynthesis; Reference proteome.
FT   CHAIN           1..351
FT                   /note="Translation initiation factor eIF-2B subunit beta"
FT                   /id="PRO_0000223470"
SQ   SEQUENCE   351 AA;  38995 MW;  557604221B37F8A8 CRC64;
     MPGAAAKGSE LSERIESFVE ALKRGGGRRS SEDMARETLG LLRRIITDHR WSNAGELMEL
     IRREGRRMTA AQPSETTVGN MVRRVLRIIR EEYGRLHGRS DESDQQESLH KLLTSGGLSE
     DFRSHYAQLQ SNIIEAINEL LVELEGTTEN IAAQALEHIH SNEVIMTIGF SRTVEAFLRE
     AARKRKFHVI VAECAPFCQG HEMAVNLSKA GIETTVMTDA AIFAVMSRVN KVIIGTKTIL
     ANGALRAVAG THTLALAAKH HSTPLIVCAP MFKLSPQFPN EEDSFHKFVA PEEVLPFTEG
     DILEKVSVHC PVFDYVPPEL ITLFISNIGG NAPSYIYRLM SELYHPDDHV L