ID   EI2BB_DICDI             Reviewed;         388 AA.
AC   Q54EY2;
DT   08-APR-2008, integrated into UniProtKB/Swiss-Prot.
DT   24-MAY-2005, sequence version 1.
DT   25-MAY-2022, entry version 98.
DE   RecName: Full=Translation initiation factor eIF-2B subunit beta;
DE   AltName: Full=eIF-2B GDP-GTP exchange factor subunit beta;
GN   Name=eif2b2; ORFNames=DDB_G0291271;
OS   Dictyostelium discoideum (Slime mold).
OC   Eukaryota; Amoebozoa; Evosea; Eumycetozoa; Dictyostelia; Dictyosteliales;
OC   Dictyosteliaceae; Dictyostelium.
OX   NCBI_TaxID=44689;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=AX4;
RX   PubMed=15875012; DOI=10.1038/nature03481;
RA   Eichinger L., Pachebat J.A., Gloeckner G., Rajandream M.A., Sucgang R.,
RA   Berriman M., Song J., Olsen R., Szafranski K., Xu Q., Tunggal B.,
RA   Kummerfeld S., Madera M., Konfortov B.A., Rivero F., Bankier A.T.,
RA   Lehmann R., Hamlin N., Davies R., Gaudet P., Fey P., Pilcher K., Chen G.,
RA   Saunders D., Sodergren E.J., Davis P., Kerhornou A., Nie X., Hall N.,
RA   Anjard C., Hemphill L., Bason N., Farbrother P., Desany B., Just E.,
RA   Morio T., Rost R., Churcher C.M., Cooper J., Haydock S., van Driessche N.,
RA   Cronin A., Goodhead I., Muzny D.M., Mourier T., Pain A., Lu M., Harper D.,
RA   Lindsay R., Hauser H., James K.D., Quiles M., Madan Babu M., Saito T.,
RA   Buchrieser C., Wardroper A., Felder M., Thangavelu M., Johnson D.,
RA   Knights A., Loulseged H., Mungall K.L., Oliver K., Price C., Quail M.A.,
RA   Urushihara H., Hernandez J., Rabbinowitsch E., Steffen D., Sanders M.,
RA   Ma J., Kohara Y., Sharp S., Simmonds M.N., Spiegler S., Tivey A.,
RA   Sugano S., White B., Walker D., Woodward J.R., Winckler T., Tanaka Y.,
RA   Shaulsky G., Schleicher M., Weinstock G.M., Rosenthal A., Cox E.C.,
RA   Chisholm R.L., Gibbs R.A., Loomis W.F., Platzer M., Kay R.R.,
RA   Williams J.G., Dear P.H., Noegel A.A., Barrell B.G., Kuspa A.;
RT   "The genome of the social amoeba Dictyostelium discoideum.";
RL   Nature 435:43-57(2005).
CC   -!- FUNCTION: Catalyzes the exchange of eukaryotic initiation factor 2-
CC       bound GDP for GTP. {ECO:0000250}.
CC   -!- SUBUNIT: Complex of five different subunits; alpha, beta, gamma, delta
CC       and epsilon. {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the eIF-2B alpha/beta/delta subunits family.
CC       {ECO:0000305}.
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DR   EMBL; AAFI02000177; EAL61619.1; -; Genomic_DNA.
DR   RefSeq; XP_635108.1; XM_630016.1.
DR   AlphaFoldDB; Q54EY2; -.
DR   SMR; Q54EY2; -.
DR   STRING; 44689.DDB0231373; -.
DR   PaxDb; Q54EY2; -.
DR   EnsemblProtists; EAL61619; EAL61619; DDB_G0291271.
DR   GeneID; 8628055; -.
DR   KEGG; ddi:DDB_G0291271; -.
DR   dictyBase; DDB_G0291271; eif2b2.
DR   eggNOG; KOG1465; Eukaryota.
DR   HOGENOM; CLU_016218_4_3_1; -.
DR   InParanoid; Q54EY2; -.
DR   OMA; TSHTSYA; -.
DR   PhylomeDB; Q54EY2; -.
DR   Reactome; R-DDI-72731; Recycling of eIF2:GDP.
DR   PRO; PR:Q54EY2; -.
DR   Proteomes; UP000002195; Chromosome 6.
DR   GO; GO:0005851; C:eukaryotic translation initiation factor 2B complex; ISS:dictyBase.
DR   GO; GO:0005085; F:guanyl-nucleotide exchange factor activity; ISS:dictyBase.
DR   GO; GO:0003743; F:translation initiation factor activity; ISS:dictyBase.
DR   GO; GO:0006413; P:translational initiation; IBA:GO_Central.
DR   Gene3D; 3.40.50.10470; -; 1.
DR   InterPro; IPR000649; IF-2B-related.
DR   InterPro; IPR042529; IF_2B-like_C.
DR   InterPro; IPR037171; NagB/RpiA_transferase-like.
DR   Pfam; PF01008; IF-2B; 1.
DR   SUPFAM; SSF100950; SSF100950; 1.
PE   3: Inferred from homology;
KW   Initiation factor; Protein biosynthesis; Reference proteome.
FT   CHAIN           1..388
FT                   /note="Translation initiation factor eIF-2B subunit beta"
FT                   /id="PRO_0000328243"
FT   REGION          109..133
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        113..133
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   388 AA;  43973 MW;  14988B6EBF1FF031 CRC64;
     MEKQAEKQLE KQLESFILHL KRKTVVGSYQ VSRASAELLR QWVHKGKWGN AKSLIDQIKI
     IGKKLMNAQP LEFCIGNIVR RVLFIIREEY LTFFRNKKNG LNNDDYDDDD FETTTSNNNN
     NNNNNNINSS SNINKNNKYS NVMLQDDPID DQEDIDFTET FPRLKAAIMD SINELIDELE
     GLHRNVAEQA IEHIHSNETI MTLGCSRTVE EFLKEAARKR SFKVIVVETA PSLEGQKTAI
     SLSKASIDTT LITDSAVFAM MSRVNKVIIG THAVMANGGL IATSGTHTLA VAAKYHSVPI
     VVCTGLYKLC PLYAYDQDTF NNFGSPGEYL KFEEAEFLEN VHSYNPTFDY VAPDLVSLFI
     TNIGGHNPSY IYRLLQEYYD ARDILEDE