ID   EI2BB_RABIT             Reviewed;         351 AA.
AC   Q28690;
DT   01-NOV-1997, integrated into UniProtKB/Swiss-Prot.
DT   01-NOV-1997, sequence version 1.
DT   25-MAY-2022, entry version 82.
DE   RecName: Full=Translation initiation factor eIF-2B subunit beta;
DE   AltName: Full=eIF-2B GDP-GTP exchange factor subunit beta;
GN   Name=EIF2B2; Synonyms=EIF2BB;
OS   Oryctolagus cuniculus (Rabbit).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Glires; Lagomorpha; Leporidae; Oryctolagus.
OX   NCBI_TaxID=9986;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA], AND PARTIAL PROTEIN SEQUENCE.
RC   STRAIN=New Zealand white; TISSUE=Liver;
RX   PubMed=7639677; DOI=10.1042/bj3091009;
RA   Craddock B.L., Price N.T., Proud C.G.;
RT   "Cloning and expression of cDNAs for the beta subunit of eukaryotic
RT   initiation factor-2B, the guanine nucleotide exchange factor for eukaryotic
RT   initiation factor-2.";
RL   Biochem. J. 309:1009-1014(1995).
CC   -!- FUNCTION: Catalyzes the exchange of eukaryotic initiation factor 2-
CC       bound GDP for GTP.
CC   -!- SUBUNIT: Complex of five different subunits; alpha, beta, gamma, delta
CC       and epsilon.
CC   -!- SIMILARITY: Belongs to the eIF-2B alpha/beta/delta subunits family.
CC       {ECO:0000305}.
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DR   EMBL; Z48222; CAA88255.1; -; mRNA.
DR   PIR; S56172; S56172.
DR   RefSeq; NP_001076100.1; NM_001082631.1.
DR   AlphaFoldDB; Q28690; -.
DR   SMR; Q28690; -.
DR   IntAct; Q28690; 2.
DR   STRING; 9986.ENSOCUP00000008770; -.
DR   GeneID; 100009318; -.
DR   KEGG; ocu:100009318; -.
DR   CTD; 8892; -.
DR   eggNOG; KOG1465; Eukaryota.
DR   InParanoid; Q28690; -.
DR   OrthoDB; 918011at2759; -.
DR   Proteomes; UP000001811; Unplaced.
DR   GO; GO:0005737; C:cytoplasm; ISS:UniProtKB.
DR   GO; GO:0005851; C:eukaryotic translation initiation factor 2B complex; ISS:UniProtKB.
DR   GO; GO:0005524; F:ATP binding; ISS:UniProtKB.
DR   GO; GO:0005525; F:GTP binding; ISS:UniProtKB.
DR   GO; GO:0003743; F:translation initiation factor activity; IEA:UniProtKB-KW.
DR   GO; GO:0007417; P:central nervous system development; ISS:UniProtKB.
DR   GO; GO:0042552; P:myelination; ISS:UniProtKB.
DR   GO; GO:0014003; P:oligodendrocyte development; ISS:UniProtKB.
DR   GO; GO:0001541; P:ovarian follicle development; ISS:UniProtKB.
DR   GO; GO:0050790; P:regulation of catalytic activity; IEA:GOC.
DR   GO; GO:0050852; P:T cell receptor signaling pathway; ISS:UniProtKB.
DR   GO; GO:0006413; P:translational initiation; ISS:UniProtKB.
DR   Gene3D; 3.40.50.10470; -; 1.
DR   InterPro; IPR000649; IF-2B-related.
DR   InterPro; IPR042529; IF_2B-like_C.
DR   InterPro; IPR037171; NagB/RpiA_transferase-like.
DR   Pfam; PF01008; IF-2B; 1.
DR   SUPFAM; SSF100950; SSF100950; 1.
PE   1: Evidence at protein level;
KW   Direct protein sequencing; Initiation factor; Protein biosynthesis;
KW   Reference proteome.
FT   CHAIN           1..351
FT                   /note="Translation initiation factor eIF-2B subunit beta"
FT                   /id="PRO_0000156063"
SQ   SEQUENCE   351 AA;  39004 MW;  05517460A3D79369 CRC64;
     MPGATEKGSE LSERIESFVE ALKRGGGQRS SEDMARETLG LLRRIITDHR WSNAGELMEL
     IRREGRRMMA AQPSETTVGN MVRRVLKIIR EEYGRLHGRS DESDQQESLH KLLTSGGLSE
     DFSFHYAQLQ SNIVEAINEL LVELEGTTEN IAAQALEHIH SNEVIMTIGL SRTVEAFLRE
     AARKRKFHVI VAECAPFCQG HEMAVNLSKA GIETTVMTDA AIFAVMSRVN KVIIGTKTIL
     ANGALRAVTG THTLALAAKH HSTPLIVCAP MFKLSPQFPN EEDSFHKFVA PEEVLPFTEG
     DILDKVGCHC PVFDYVPPEL ITLFISNIGG NAPSYIYRLM SELYHPEDHV L