ID   EI2BB_RAT               Reviewed;         351 AA.
AC   Q62818; O08956;
DT   01-NOV-1997, integrated into UniProtKB/Swiss-Prot.
DT   01-NOV-1997, sequence version 1.
DT   25-MAY-2022, entry version 106.
DE   RecName: Full=Translation initiation factor eIF-2B subunit beta;
DE   AltName: Full=eIF-2B GDP-GTP exchange factor subunit beta;
GN   Name=Eif2b2; Synonyms=Eif2bb;
OS   Rattus norvegicus (Rat).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC   Murinae; Rattus.
OX   NCBI_TaxID=10116;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RC   STRAIN=Sprague-Dawley;
RX   PubMed=8929216; DOI=10.1042/bj3180637;
RA   Price N.T., Mellor H., Craddock B.L., Flowers K.M., Kimball S.R.,
RA   Wilmer T., Jefferson L.S., Proud C.G.;
RT   "eIF2B, the guanine nucleotide-exchange factor for eukaryotic initiation
RT   factor 2. Sequence conservation between the alpha, beta and delta subunits
RT   of eIF2B from mammals and yeast.";
RL   Biochem. J. 318:637-643(1996).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RC   STRAIN=Sprague-Dawley; TISSUE=Brain;
RX   PubMed=9139680; DOI=10.1074/jbc.272.19.12359;
RA   Fabian J.R., Kimball S.R., Heinzinger N.K., Jefferson L.S.;
RT   "Subunit assembly and guanine nucleotide exchange activity of eukaryotic
RT   initiation factor-2B expressed in Sf9 cells.";
RL   J. Biol. Chem. 272:12359-12365(1997).
CC   -!- FUNCTION: Catalyzes the exchange of eukaryotic initiation factor 2-
CC       bound GDP for GTP.
CC   -!- SUBUNIT: Complex of five different subunits; alpha, beta, gamma, delta
CC       and epsilon.
CC   -!- SIMILARITY: Belongs to the eIF-2B alpha/beta/delta subunits family.
CC       {ECO:0000305}.
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DR   EMBL; U31880; AAB38753.1; -; mRNA.
DR   EMBL; U83914; AAB58527.1; -; mRNA.
DR   PIR; S71960; S71960.
DR   AlphaFoldDB; Q62818; -.
DR   SMR; Q62818; -.
DR   STRING; 10116.ENSRNOP00000008730; -.
DR   iPTMnet; Q62818; -.
DR   PhosphoSitePlus; Q62818; -.
DR   jPOST; Q62818; -.
DR   PaxDb; Q62818; -.
DR   PRIDE; Q62818; -.
DR   UCSC; RGD:620820; rat.
DR   RGD; 620820; Eif2b2.
DR   eggNOG; KOG1465; Eukaryota.
DR   InParanoid; Q62818; -.
DR   PhylomeDB; Q62818; -.
DR   Reactome; R-RNO-72731; Recycling of eIF2:GDP.
DR   PRO; PR:Q62818; -.
DR   Proteomes; UP000002494; Unplaced.
DR   GO; GO:0030424; C:axon; IDA:RGD.
DR   GO; GO:0005737; C:cytoplasm; ISS:UniProtKB.
DR   GO; GO:0005851; C:eukaryotic translation initiation factor 2B complex; IDA:RGD.
DR   GO; GO:0005524; F:ATP binding; ISS:UniProtKB.
DR   GO; GO:0005525; F:GTP binding; ISS:UniProtKB.
DR   GO; GO:0003743; F:translation initiation factor activity; IBA:GO_Central.
DR   GO; GO:0007417; P:central nervous system development; ISS:UniProtKB.
DR   GO; GO:0021766; P:hippocampus development; IEP:RGD.
DR   GO; GO:0042552; P:myelination; ISS:UniProtKB.
DR   GO; GO:0014003; P:oligodendrocyte development; ISS:UniProtKB.
DR   GO; GO:0001541; P:ovarian follicle development; ISS:UniProtKB.
DR   GO; GO:0045773; P:positive regulation of axon extension; IMP:RGD.
DR   GO; GO:0050790; P:regulation of catalytic activity; IEA:GOC.
DR   GO; GO:0009749; P:response to glucose; IDA:UniProtKB.
DR   GO; GO:0009408; P:response to heat; IDA:UniProtKB.
DR   GO; GO:0043434; P:response to peptide hormone; IDA:UniProtKB.
DR   GO; GO:0050852; P:T cell receptor signaling pathway; ISS:UniProtKB.
DR   GO; GO:0006413; P:translational initiation; ISS:UniProtKB.
DR   Gene3D; 3.40.50.10470; -; 1.
DR   InterPro; IPR000649; IF-2B-related.
DR   InterPro; IPR042529; IF_2B-like_C.
DR   InterPro; IPR037171; NagB/RpiA_transferase-like.
DR   Pfam; PF01008; IF-2B; 1.
DR   SUPFAM; SSF100950; SSF100950; 1.
PE   2: Evidence at transcript level;
KW   Initiation factor; Protein biosynthesis; Reference proteome.
FT   CHAIN           1..351
FT                   /note="Translation initiation factor eIF-2B subunit beta"
FT                   /id="PRO_0000156064"
FT   CONFLICT        30
FT                   /note="T -> S (in Ref. 2; AAB58527)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        72..74
FT                   /note="HPP -> QPS (in Ref. 2; AAB58527)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        93..95
FT                   /note="Missing (in Ref. 2; AAB58527)"
FT                   /evidence="ECO:0000305"
SQ   SEQUENCE   351 AA;  38875 MW;  9282A2CFAE438043 CRC64;
     MPGAAAKGSE LSERIESFVE TLKRGGGRRT SEDMARETLG LLRRLITDHH WNNAGDLMDL
     IRREGRRMTA AHPPETTVGN MVRRVLKIIR EEYGRLHGRS DESDQQESLH KLLTSGGLSE
     DFSFHYAPLK SNIIEAINEL LVELEGTTEN IAAQALEHIH SNEVIMTIGF SRTVEAFLRE
     AAQKRKFHVI AAECAPFCQG HEMAVNLSEA GIETTVMTDA AIFAVMSRVN KVIIGTKTIL
     ANGSLRAVAG THTLALAAKH HSTPLIVCAP MFKLSPQFPS EEDSFHKFVA PEEVLPFTEG
     DILEKVSVHC PVFDYVPPDL ITLFISNIGG NAPSYVYRLM SELYHPDDHV L