ID   EI2BD_BOVIN             Reviewed;         524 AA.
AC   Q3T058;
DT   05-FEB-2008, integrated into UniProtKB/Swiss-Prot.
DT   11-OCT-2005, sequence version 1.
DT   03-AUG-2022, entry version 80.
DE   RecName: Full=Translation initiation factor eIF-2B subunit delta;
DE   AltName: Full=eIF-2B GDP-GTP exchange factor subunit delta;
GN   Name=EIF2B4;
OS   Bos taurus (Bovine).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
OC   Bovinae; Bos.
OX   NCBI_TaxID=9913;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   STRAIN=Hereford; TISSUE=Testis;
RG   NIH - Mammalian Gene Collection (MGC) project;
RL   Submitted (AUG-2005) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Catalyzes the exchange of eukaryotic initiation factor 2-
CC       bound GDP for GTP. {ECO:0000250}.
CC   -!- SUBUNIT: Complex of five different subunits; alpha, beta, gamma, delta
CC       and epsilon. {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the eIF-2B alpha/beta/delta subunits family.
CC       {ECO:0000305}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; BC102555; AAI02556.1; -; mRNA.
DR   RefSeq; NP_001029716.1; NM_001034544.2.
DR   AlphaFoldDB; Q3T058; -.
DR   SMR; Q3T058; -.
DR   STRING; 9913.ENSBTAP00000025991; -.
DR   PaxDb; Q3T058; -.
DR   PRIDE; Q3T058; -.
DR   GeneID; 521926; -.
DR   KEGG; bta:521926; -.
DR   CTD; 8890; -.
DR   eggNOG; KOG1467; Eukaryota.
DR   InParanoid; Q3T058; -.
DR   OrthoDB; 797227at2759; -.
DR   Proteomes; UP000009136; Unplaced.
DR   GO; GO:0005737; C:cytoplasm; ISS:UniProtKB.
DR   GO; GO:0005851; C:eukaryotic translation initiation factor 2B complex; ISS:UniProtKB.
DR   GO; GO:0003743; F:translation initiation factor activity; IEA:UniProtKB-KW.
DR   GO; GO:0042552; P:myelination; ISS:UniProtKB.
DR   GO; GO:0014003; P:oligodendrocyte development; ISS:UniProtKB.
DR   GO; GO:0001541; P:ovarian follicle development; ISS:UniProtKB.
DR   GO; GO:0050790; P:regulation of catalytic activity; IEA:GOC.
DR   GO; GO:0050852; P:T cell receptor signaling pathway; ISS:UniProtKB.
DR   GO; GO:0006413; P:translational initiation; ISS:UniProtKB.
DR   Gene3D; 3.40.50.10470; -; 1.
DR   InterPro; IPR000649; IF-2B-related.
DR   InterPro; IPR042529; IF_2B-like_C.
DR   InterPro; IPR037171; NagB/RpiA_transferase-like.
DR   Pfam; PF01008; IF-2B; 1.
DR   SUPFAM; SSF100950; SSF100950; 1.
PE   2: Evidence at transcript level;
KW   Acetylation; Initiation factor; Phosphoprotein; Protein biosynthesis;
KW   Reference proteome.
FT   INIT_MET        1
FT                   /note="Removed"
FT                   /evidence="ECO:0000250|UniProtKB:Q9UI10"
FT   CHAIN           2..524
FT                   /note="Translation initiation factor eIF-2B subunit delta"
FT                   /id="PRO_0000317332"
FT   REGION          1..173
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        92..118
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        145..171
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   MOD_RES         2
FT                   /note="N-acetylalanine"
FT                   /evidence="ECO:0000250|UniProtKB:Q9UI10"
FT   MOD_RES         12
FT                   /note="Phosphoserine"
FT                   /evidence="ECO:0000250|UniProtKB:Q9UI10"
FT   MOD_RES         86
FT                   /note="Phosphothreonine"
FT                   /evidence="ECO:0000250|UniProtKB:Q9UI10"
SQ   SEQUENCE   524 AA;  57469 MW;  78BE7BA6E1F02BA5 CRC64;
     MATAAVAVRE DSGSGMKAEL APRPGAEGRE MTQEEKLQLR KEKKQQKKKR KEEKGTETET
     GSAVSAAQCQ VGPAKHLAGP DSQLGTAKEK VPAGRSKAEL RAERRAKQEA ERAMKQARKG
     DQGGPPPQAC PSTAGETPSG VKRLPEHSQV DDPTLLRRLV KKPERQQVPT RKDYGSKVSL
     FSHLPQYSRQ NSLTQFMSIP SSVIHPAMVR LGLQYSQGLV SGSNARCIAL LRALQQVIQD
     YTTPPSEELS RDLVNKLKPY FSFLTQCRPL SASMYNAIKL LNKEITGVSG SKREEEAKSE
     LRAAIDRYIK EKIVLAAQAI SRFAYKKISN GDVILVYGCS SLVSHILQEA WAKGRQFRVV
     VVDSRPRLEA KHTLRSLVRA GVPASYLLIP AASYVLPEVS KVLLGAHALL ANGSVMSRVG
     TAQLALVARA HNVPVLVCCE TYKFCERVQT DAFVSNELDD PDDLLCERGE HVALANWQNH
     SSLRLLNLVY DVTPPELVDL VITELGMIPC SSVPVVLRVK SSDQ