ID   EI2BD_DICDI             Reviewed;         619 AA.
AC   Q54FM3;
DT   29-APR-2008, integrated into UniProtKB/Swiss-Prot.
DT   24-MAY-2005, sequence version 1.
DT   25-MAY-2022, entry version 93.
DE   RecName: Full=Translation initiation factor eIF-2B subunit delta;
DE   AltName: Full=eIF-2B GDP-GTP exchange factor subunit delta;
GN   Name=eif2b4; ORFNames=DDB_G0290759;
OS   Dictyostelium discoideum (Slime mold).
OC   Eukaryota; Amoebozoa; Evosea; Eumycetozoa; Dictyostelia; Dictyosteliales;
OC   Dictyosteliaceae; Dictyostelium.
OX   NCBI_TaxID=44689;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=AX4;
RX   PubMed=15875012; DOI=10.1038/nature03481;
RA   Eichinger L., Pachebat J.A., Gloeckner G., Rajandream M.A., Sucgang R.,
RA   Berriman M., Song J., Olsen R., Szafranski K., Xu Q., Tunggal B.,
RA   Kummerfeld S., Madera M., Konfortov B.A., Rivero F., Bankier A.T.,
RA   Lehmann R., Hamlin N., Davies R., Gaudet P., Fey P., Pilcher K., Chen G.,
RA   Saunders D., Sodergren E.J., Davis P., Kerhornou A., Nie X., Hall N.,
RA   Anjard C., Hemphill L., Bason N., Farbrother P., Desany B., Just E.,
RA   Morio T., Rost R., Churcher C.M., Cooper J., Haydock S., van Driessche N.,
RA   Cronin A., Goodhead I., Muzny D.M., Mourier T., Pain A., Lu M., Harper D.,
RA   Lindsay R., Hauser H., James K.D., Quiles M., Madan Babu M., Saito T.,
RA   Buchrieser C., Wardroper A., Felder M., Thangavelu M., Johnson D.,
RA   Knights A., Loulseged H., Mungall K.L., Oliver K., Price C., Quail M.A.,
RA   Urushihara H., Hernandez J., Rabbinowitsch E., Steffen D., Sanders M.,
RA   Ma J., Kohara Y., Sharp S., Simmonds M.N., Spiegler S., Tivey A.,
RA   Sugano S., White B., Walker D., Woodward J.R., Winckler T., Tanaka Y.,
RA   Shaulsky G., Schleicher M., Weinstock G.M., Rosenthal A., Cox E.C.,
RA   Chisholm R.L., Gibbs R.A., Loomis W.F., Platzer M., Kay R.R.,
RA   Williams J.G., Dear P.H., Noegel A.A., Barrell B.G., Kuspa A.;
RT   "The genome of the social amoeba Dictyostelium discoideum.";
RL   Nature 435:43-57(2005).
CC   -!- FUNCTION: Catalyzes the exchange of eukaryotic initiation factor 2-
CC       bound GDP for GTP. {ECO:0000250}.
CC   -!- SUBUNIT: Complex of five different subunits; alpha, beta, gamma, delta
CC       and epsilon. {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the eIF-2B alpha/beta/delta subunits family.
CC       {ECO:0000305}.
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DR   EMBL; AAFI02000170; EAL62064.1; -; Genomic_DNA.
DR   RefSeq; XP_635568.1; XM_630476.1.
DR   AlphaFoldDB; Q54FM3; -.
DR   SMR; Q54FM3; -.
DR   STRING; 44689.DDB0232421; -.
DR   PaxDb; Q54FM3; -.
DR   EnsemblProtists; EAL62064; EAL62064; DDB_G0290759.
DR   GeneID; 8627814; -.
DR   KEGG; ddi:DDB_G0290759; -.
DR   dictyBase; DDB_G0290759; eif2b4.
DR   eggNOG; KOG1467; Eukaryota.
DR   HOGENOM; CLU_016218_3_2_1; -.
DR   InParanoid; Q54FM3; -.
DR   OMA; HAYKAIS; -.
DR   PhylomeDB; Q54FM3; -.
DR   Reactome; R-DDI-72731; Recycling of eIF2:GDP.
DR   PRO; PR:Q54FM3; -.
DR   Proteomes; UP000002195; Chromosome 5.
DR   GO; GO:0005851; C:eukaryotic translation initiation factor 2B complex; ISS:dictyBase.
DR   GO; GO:0003743; F:translation initiation factor activity; ISS:dictyBase.
DR   GO; GO:0006413; P:translational initiation; ISS:dictyBase.
DR   Gene3D; 3.40.50.10470; -; 1.
DR   InterPro; IPR000649; IF-2B-related.
DR   InterPro; IPR042529; IF_2B-like_C.
DR   InterPro; IPR037171; NagB/RpiA_transferase-like.
DR   Pfam; PF01008; IF-2B; 1.
DR   SUPFAM; SSF100950; SSF100950; 1.
PE   3: Inferred from homology;
KW   Initiation factor; Protein biosynthesis; Reference proteome.
FT   CHAIN           1..619
FT                   /note="Translation initiation factor eIF-2B subunit delta"
FT                   /id="PRO_0000329968"
FT   REGION          21..251
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        35..196
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        197..251
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   619 AA;  69244 MW;  A7FC4622A6AC9282 CRC64;
     MSSFGKNSSY RDTGASLKEL GDYLDSKQEG KPTHQKTIGF DTNTSPVSIP TIISPPLGSN
     NSNYGKSPKS SYDNKQTSPL LSASNNRKNN NNNNNNNNAT SPKDSSIIGK NNVNSDLSKV
     SSSLNELKFE KQPIGSTSST PTSTPSSTPS SSTPSSTPST PNTNSQQQQQ QQQQQKKQQQ
     QQPKQPQQPK QQSKQQATQQ DKKDKEQQQQ QQDKQDKESN EIKGSKEVAK DGQHGVKQFD
     DPKQRGKITK KKIIKVGESS RSVQLFNHLP QYNSEFSMGV SVSTDEPNEK YPIHPDIISL
     GLKYAEFKIA GSNARAIAMM TAFIQIFKDY VAAPDKVYSR ELDSLLKRNI QFLVDCRPIS
     ISMGNSINYV KHKLSLTNNM SHEGARDYLI KSINEFIERI QMADNAIVKH GCSKINDGDV
     ILTYASSHVV ELIIQQAIQD KKKFRLIIVD SRPKHEGREL LHRLVLHGVK ITYIMLHAVS
     YIMKEVTKVF VGAYSVLSNG NLISRSGTSL VASMAKFYNV PFIVCCETYK FTERVQLDSI
     CFNQIGNPQD LVQNLGEKEG SKSLLENWES YSTLKLLNLM YDLTPIELID MVITEFGMLP
     PTSIPVVLRE YRKEVISIN