EI2BE_CANAL
ID EI2BE_CANAL Reviewed; 732 AA.
AC P87163; A0A1D8PEB7; Q59QB1;
DT 01-NOV-1997, integrated into UniProtKB/Swiss-Prot.
DT 15-MAR-2017, sequence version 3.
DT 03-AUG-2022, entry version 102.
DE RecName: Full=Translation initiation factor eIF-2B subunit epsilon;
DE AltName: Full=GCD complex subunit GCD6;
DE AltName: Full=Guanine nucleotide exchange factor subunit GCD6;
DE AltName: Full=eIF-2B GDP-GTP exchange factor subunit epsilon;
GN Name=GCD6; Synonyms=TIF225; OrderedLocusNames=CAALFM_C108600CA;
GN ORFNames=CaO19.407, CaO19.8037;
OS Candida albicans (strain SC5314 / ATCC MYA-2876) (Yeast).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC Saccharomycetales; Debaryomycetaceae; Candida/Lodderomyces clade; Candida.
OX NCBI_TaxID=237561;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=SC5314 / ATCC MYA-2876;
RX PubMed=15123810; DOI=10.1073/pnas.0401648101;
RA Jones T., Federspiel N.A., Chibana H., Dungan J., Kalman S., Magee B.B.,
RA Newport G., Thorstenson Y.R., Agabian N., Magee P.T., Davis R.W.,
RA Scherer S.;
RT "The diploid genome sequence of Candida albicans.";
RL Proc. Natl. Acad. Sci. U.S.A. 101:7329-7334(2004).
RN [2]
RP GENOME REANNOTATION.
RC STRAIN=SC5314 / ATCC MYA-2876;
RX PubMed=17419877; DOI=10.1186/gb-2007-8-4-r52;
RA van het Hoog M., Rast T.J., Martchenko M., Grindle S., Dignard D.,
RA Hogues H., Cuomo C., Berriman M., Scherer S., Magee B.B., Whiteway M.,
RA Chibana H., Nantel A., Magee P.T.;
RT "Assembly of the Candida albicans genome into sixteen supercontigs aligned
RT on the eight chromosomes.";
RL Genome Biol. 8:RESEARCH52.1-RESEARCH52.12(2007).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA], AND GENOME REANNOTATION.
RC STRAIN=SC5314 / ATCC MYA-2876;
RX PubMed=24025428; DOI=10.1186/gb-2013-14-9-r97;
RA Muzzey D., Schwartz K., Weissman J.S., Sherlock G.;
RT "Assembly of a phased diploid Candida albicans genome facilitates allele-
RT specific measurements and provides a simple model for repeat and indel
RT structure.";
RL Genome Biol. 14:RESEARCH97.1-RESEARCH97.14(2013).
RN [4]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 544-732.
RC STRAIN=SFI-0124;
RX PubMed=9161422; DOI=10.1016/s0378-1119(96)00844-x;
RA Favre B., Ryder N.S.;
RT "Cloning and expression of squalene epoxidase from the pathogenic yeast
RT Candida albicans.";
RL Gene 189:119-126(1997).
CC -!- FUNCTION: Subunit of the guanine nucleotide exchange factor for eIF-2.
CC {ECO:0000250}.
CC -!- SUBUNIT: Complex of five different subunits; alpha (GCN3), beta (GCD7),
CC gamma (GCD1), delta (GCD2) and epsilon (GCD6). {ECO:0000250}.
CC -!- SIMILARITY: Belongs to the eIF-2B gamma/epsilon subunits family.
CC {ECO:0000305}.
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DR EMBL; CP017623; AOW26498.1; -; Genomic_DNA.
DR EMBL; U69674; AAC49714.1; -; Genomic_DNA.
DR RefSeq; XP_711895.2; XM_706802.2.
DR AlphaFoldDB; P87163; -.
DR SMR; P87163; -.
DR BioGRID; 1229552; 2.
DR STRING; 237561.P87163; -.
DR PRIDE; P87163; -.
DR GeneID; 3646510; -.
DR KEGG; cal:CAALFM_C108600CA; -.
DR CGD; CAL0000183518; GCD6.
DR VEuPathDB; FungiDB:C1_08600C_A; -.
DR eggNOG; KOG1461; Eukaryota.
DR HOGENOM; CLU_012507_1_0_1; -.
DR InParanoid; P87163; -.
DR OrthoDB; 369837at2759; -.
DR PRO; PR:P87163; -.
DR Proteomes; UP000000559; Chromosome 1.
DR GO; GO:0005851; C:eukaryotic translation initiation factor 2B complex; IBA:GO_Central.
DR GO; GO:0005085; F:guanyl-nucleotide exchange factor activity; IBA:GO_Central.
DR GO; GO:0016779; F:nucleotidyltransferase activity; IEA:InterPro.
DR GO; GO:0003743; F:translation initiation factor activity; IBA:GO_Central.
DR GO; GO:0031369; F:translation initiation factor binding; IBA:GO_Central.
DR GO; GO:0002183; P:cytoplasmic translational initiation; IEA:EnsemblFungi.
DR CDD; cd04197; eIF-2B_epsilon_N; 1.
DR CDD; cd11558; W2_eIF2B_epsilon; 1.
DR Gene3D; 3.90.550.10; -; 1.
DR InterPro; IPR016024; ARM-type_fold.
DR InterPro; IPR035543; eIF-2B_epsilon_N.
DR InterPro; IPR001451; Hexapep.
DR InterPro; IPR005835; NTP_transferase_dom.
DR InterPro; IPR029044; Nucleotide-diphossugar_trans.
DR InterPro; IPR011004; Trimer_LpxA-like_sf.
DR InterPro; IPR003307; W2_domain.
DR InterPro; IPR044123; W2_eIF2B_epsilon.
DR Pfam; PF00132; Hexapep; 2.
DR Pfam; PF00483; NTP_transferase; 1.
DR Pfam; PF02020; W2; 1.
DR SMART; SM00515; eIF5C; 1.
DR SUPFAM; SSF48371; SSF48371; 1.
DR SUPFAM; SSF51161; SSF51161; 1.
DR SUPFAM; SSF53448; SSF53448; 1.
DR PROSITE; PS51363; W2; 1.
PE 3: Inferred from homology;
KW Initiation factor; Protein biosynthesis; Reference proteome.
FT CHAIN 1..732
FT /note="Translation initiation factor eIF-2B subunit
FT epsilon"
FT /id="PRO_0000156076"
FT DOMAIN 559..726
FT /note="W2"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00695"
SQ SEQUENCE 732 AA; 81952 MW; A7C2E826A30376BB CRC64;
MAPKSKKQAA TQSKSKKSKD LVDERFQAIV LTDSFETRFM PLTAVHPRCL LPLANVPLIE
YTLEFLANAG VNEVYLMCSA HADQIQEYIE NSKWMGDNSP FSVTTIMSIE SRSVGDTMRD
LDNRGLIAGD FLLVSGDVVT NMDFSKALQF HKQKKAQDKD HIATMVLNQA SPLHRTRSQI
DPAAFVLDKE TNRCIFYQSI PPVSGKKTCI SIDPELLEDF QGELQVRNDL IDCHVDICSP
HVPQIFQENF DYQYLRSDFL KGVLTSDLLK KTIYAYISKD SSEYAARVES WSTYDAISQD
ILARWCYPLV PDSNLVEGNS YSYELNNIYK EDKIILAQSC KIGTSTSIGR NSSVGEGTQI
KNSVIGRNCT IGKNVVIENS YIWDNAVIKD NSVLNRSIVA ADAQIGNNVT LSPGSVIGFN
VIIGDDKVIP HNVKIVETPI VTENEFGDFD DESNSEDENE YEDGNAVPVL AVKDVELVGE
TGKGFAYESE IESGDEDDEE FVGNGTYSGI IYQMKSLNVS DDSIASVSNK KVKKHSHRRR
LSMNSMISDN GGAFESDEGE EEEDFGVEGL ATVTRAIENN HDIDTALLEL NTLRMSMNVT
YHDVRSVTTQ ALVNKIVDFI TTGTLTPQEA ATKIFTKWGI MFKRQVFSPE EEVDLLNIVE
EKSSVLDKAY NQIVLFLGVK SFYDMEVVEE ENILKWWNDG ENDEVRTLAA KFITWLQEAD
EEDSDEDDED SE
