ID   EI2BG_BOVIN             Reviewed;         452 AA.
AC   A5PJI7;
DT   05-FEB-2008, integrated into UniProtKB/Swiss-Prot.
DT   10-JUL-2007, sequence version 1.
DT   25-MAY-2022, entry version 64.
DE   RecName: Full=Translation initiation factor eIF-2B subunit gamma;
DE   AltName: Full=eIF-2B GDP-GTP exchange factor subunit gamma;
GN   Name=EIF2B3;
OS   Bos taurus (Bovine).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
OC   Bovinae; Bos.
OX   NCBI_TaxID=9913;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   STRAIN=Hereford; TISSUE=Brain cortex;
RG   NIH - Mammalian Gene Collection (MGC) project;
RL   Submitted (JUN-2007) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Catalyzes the exchange of eukaryotic initiation factor 2-
CC       bound GDP for GTP. {ECO:0000250}.
CC   -!- SUBUNIT: Complex of five different subunits; alpha, beta, gamma, delta
CC       and epsilon. {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the eIF-2B gamma/epsilon subunits family.
CC       {ECO:0000305}.
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DR   EMBL; BC142127; AAI42128.1; -; mRNA.
DR   AlphaFoldDB; A5PJI7; -.
DR   SMR; A5PJI7; -.
DR   STRING; 9913.ENSBTAP00000049588; -.
DR   eggNOG; KOG1462; Eukaryota.
DR   InParanoid; A5PJI7; -.
DR   Proteomes; UP000009136; Unplaced.
DR   GO; GO:0005737; C:cytoplasm; ISS:UniProtKB.
DR   GO; GO:0005851; C:eukaryotic translation initiation factor 2B complex; ISS:UniProtKB.
DR   GO; GO:0016779; F:nucleotidyltransferase activity; IEA:InterPro.
DR   GO; GO:0003743; F:translation initiation factor activity; IEA:UniProtKB-KW.
DR   GO; GO:0014003; P:oligodendrocyte development; ISS:UniProtKB.
DR   GO; GO:0050790; P:regulation of catalytic activity; IEA:GOC.
DR   GO; GO:0050852; P:T cell receptor signaling pathway; ISS:UniProtKB.
DR   GO; GO:0006413; P:translational initiation; ISS:UniProtKB.
DR   Gene3D; 3.90.550.10; -; 1.
DR   InterPro; IPR005835; NTP_transferase_dom.
DR   InterPro; IPR029044; Nucleotide-diphossugar_trans.
DR   Pfam; PF00483; NTP_transferase; 1.
DR   SUPFAM; SSF53448; SSF53448; 1.
PE   2: Evidence at transcript level;
KW   Acetylation; Initiation factor; Phosphoprotein; Protein biosynthesis;
KW   Reference proteome.
FT   CHAIN           1..452
FT                   /note="Translation initiation factor eIF-2B subunit gamma"
FT                   /id="PRO_0000317331"
FT   MOD_RES         1
FT                   /note="N-acetylmethionine"
FT                   /evidence="ECO:0000250|UniProtKB:Q9NR50"
FT   MOD_RES         261
FT                   /note="Phosphoserine"
FT                   /evidence="ECO:0000250|UniProtKB:Q9NR50"
SQ   SEQUENCE   452 AA;  50218 MW;  A58454090E7F0623 CRC64;
     MEFQAVVMAV GGGSRMTDLT SSIPKPLLPV GNKPLIWYPL NLLERVGFEE VIVITTKDVQ
     KALCADFNKM KMKLDIVCIP DEADMGTADS LRHIYQKLKT DVLVLSCDLI TDVALHEVVD
     LFRAHDASLA MLMRKGQESL EPVPGQKGKK KAVEQRDFVG VDSTGKRLLF MANEADLDEE
     LIIKGSILQK HPRIRFHTGL VDAHLYCLKK YVVDFLMENK SITSIRSELI PYLVRKQFSS
     ASSQQGQEEK EEDLKKKELK SLDIYSFIKE ANTLTLAPYD TCWNACRGDS WEGLSRSQVR
     CYVHIMKEGL CSRVSTLGLY MEANRQVSKL LPVICPEESL IHSSAQIVSK HMVGADSLIG
     PDTQVGEKSS IKHSVIGSSC VIRDRVTVTN CLLMNSVTVE EGSNIQSSII CNDAVIEKGA
     DIKNCLIGSG QRIEAKAKRV NVIVGNDQFL EI