ID   EI2BG_CAEEL             Reviewed;         404 AA.
AC   P80361; P42004; Q9N5Y4;
DT   01-NOV-1995, integrated into UniProtKB/Swiss-Prot.
DT   20-JUN-2002, sequence version 3.
DT   03-AUG-2022, entry version 140.
DE   RecName: Full=Probable translation initiation factor eIF-2B subunit gamma;
DE   AltName: Full=Putative pyrophosphorylase ppp-1;
DE   AltName: Full=eIF-2B GDP-GTP exchange factor subunit gamma;
GN   Name=eif-2Bgamma {ECO:0000303|PubMed:8809057,
GN   ECO:0000312|WormBase:C15F1.4}; Synonyms=ppp-1 {ECO:0000303|PubMed:7971272};
GN   ORFNames=C15F1.4 {ECO:0000312|WormBase:C15F1.4};
OS   Caenorhabditis elegans.
OC   Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC   Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae;
OC   Caenorhabditis.
OX   NCBI_TaxID=6239;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RX   PubMed=7971272; DOI=10.1093/nar/22.21.4414;
RA   Kuwabara P.E., Shah S.;
RT   "Cloning by synteny: identifying C. briggsae homologues of C. elegans
RT   genes.";
RL   Nucleic Acids Res. 22:4414-4418(1994).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Bristol N2;
RX   PubMed=9851916; DOI=10.1126/science.282.5396.2012;
RG   The C. elegans sequencing consortium;
RT   "Genome sequence of the nematode C. elegans: a platform for investigating
RT   biology.";
RL   Science 282:2012-2018(1998).
RN   [3]
RP   IDENTIFICATION OF FRAMESHIFT.
RX   PubMed=8809057; DOI=10.1042/bj3180631;
RA   Price N.T., Kimball S.R., Jefferson L.S., Proud C.G.;
RT   "Cloning of cDNA for the gamma-subunit of mammalian translation initiation
RT   factor 2B, the guanine nucleotide-exchange factor for eukaryotic initiation
RT   factor 2.";
RL   Biochem. J. 318:631-636(1996).
CC   -!- FUNCTION: Catalyzes the exchange of eukaryotic initiation factor 2-
CC       bound GDP for GTP. {ECO:0000250|UniProtKB:P09032}.
CC   -!- SUBUNIT: Complex of five different subunits; alpha, beta, gamma, delta
CC       and epsilon. {ECO:0000250|UniProtKB:P09032}.
CC   -!- SIMILARITY: Belongs to the eIF-2B gamma/epsilon subunits family.
CC       {ECO:0000305}.
CC   -!- SEQUENCE CAUTION:
CC       Sequence=AAA64269.1; Type=Frameshift; Evidence={ECO:0000305};
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DR   EMBL; U14521; AAA64269.1; ALT_FRAME; mRNA.
DR   EMBL; FO080553; CCD64613.1; -; Genomic_DNA.
DR   RefSeq; NP_495428.1; NM_063027.5.
DR   AlphaFoldDB; P80361; -.
DR   SMR; P80361; -.
DR   BioGRID; 39476; 2.
DR   STRING; 6239.C15F1.4; -.
DR   EPD; P80361; -.
DR   PaxDb; P80361; -.
DR   PeptideAtlas; P80361; -.
DR   EnsemblMetazoa; C15F1.4.1; C15F1.4.1; WBGene00004090.
DR   GeneID; 174138; -.
DR   KEGG; cel:CELE_C15F1.4; -.
DR   UCSC; C15F1.4; c. elegans.
DR   CTD; 174138; -.
DR   WormBase; C15F1.4; CE23548; WBGene00004090; eif-2Bgamma.
DR   eggNOG; KOG1462; Eukaryota.
DR   GeneTree; ENSGT00510000047486; -.
DR   HOGENOM; CLU_016743_0_0_1; -.
DR   InParanoid; P80361; -.
DR   OMA; QAFIFCG; -.
DR   OrthoDB; 1388750at2759; -.
DR   PhylomeDB; P80361; -.
DR   Reactome; R-CEL-72731; Recycling of eIF2:GDP.
DR   PRO; PR:P80361; -.
DR   Proteomes; UP000001940; Chromosome II.
DR   Bgee; WBGene00004090; Expressed in adult organism and 3 other tissues.
DR   GO; GO:0005737; C:cytoplasm; IDA:WormBase.
DR   GO; GO:0005851; C:eukaryotic translation initiation factor 2B complex; IBA:GO_Central.
DR   GO; GO:0032045; C:guanyl-nucleotide exchange factor complex; IBA:GO_Central.
DR   GO; GO:0005085; F:guanyl-nucleotide exchange factor activity; IBA:GO_Central.
DR   GO; GO:0016779; F:nucleotidyltransferase activity; IEA:InterPro.
DR   GO; GO:0003743; F:translation initiation factor activity; IBA:GO_Central.
DR   GO; GO:0002183; P:cytoplasmic translational initiation; IBA:GO_Central.
DR   Gene3D; 3.90.550.10; -; 1.
DR   InterPro; IPR005835; NTP_transferase_dom.
DR   InterPro; IPR029044; Nucleotide-diphossugar_trans.
DR   InterPro; IPR011004; Trimer_LpxA-like_sf.
DR   Pfam; PF00483; NTP_transferase; 1.
DR   SUPFAM; SSF51161; SSF51161; 1.
DR   SUPFAM; SSF53448; SSF53448; 1.
PE   2: Evidence at transcript level;
KW   Initiation factor; Protein biosynthesis; Reference proteome.
FT   CHAIN           1..404
FT                   /note="Probable translation initiation factor eIF-2B
FT                   subunit gamma"
FT                   /id="PRO_0000156081"
SQ   SEQUENCE   404 AA;  44779 MW;  1F6D179D1F3A777B CRC64;
     MHEMQGILLC SGGGTRMPVL TRHVQKCLLP VVGVPMFLYP LSSLLRTGIT DIKIFVREVL
     QLTLEKEVKK SKLLEKYPAH IEYICVNQED FGTADLLKNH HSKITKDALI VSCDFISDAS
     LIPLVDFFRA TNSTLVALIA DTCVNAPAPG SKSKKPKATD VMAIVESTGQ LAFLCGDDDF
     DAPLVMEKSL KIFPSIKLTS KYNDCHVYAI RHKVLLNLSK SKHISSFKAD FVPLLIDKQF
     EPDSDIKCFA YRLPHENGFV TAHANTLGSY FEVNKAIQKS FTRLMEYRGN GKNFNYKTDK
     IAAHESRIEE SAEIDKDSVI KRSFISDNCR IGEKTKLKES IIAKGVVIGN GASISNSIIC
     DGVEIGENAD VTNCIVAKDQ KVPAKGKVQN EVVEDGEDEE WTDD