ID   EI2BG_DICDI             Reviewed;         440 AA.
AC   Q54FQ8;
DT   08-APR-2008, integrated into UniProtKB/Swiss-Prot.
DT   24-MAY-2005, sequence version 1.
DT   25-MAY-2022, entry version 88.
DE   RecName: Full=Translation initiation factor eIF-2B subunit gamma;
DE   AltName: Full=eIF-2B GDP-GTP exchange factor subunit gamma;
GN   Name=eif2b3; ORFNames=DDB_G0290693;
OS   Dictyostelium discoideum (Slime mold).
OC   Eukaryota; Amoebozoa; Evosea; Eumycetozoa; Dictyostelia; Dictyosteliales;
OC   Dictyosteliaceae; Dictyostelium.
OX   NCBI_TaxID=44689;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=AX4;
RX   PubMed=15875012; DOI=10.1038/nature03481;
RA   Eichinger L., Pachebat J.A., Gloeckner G., Rajandream M.A., Sucgang R.,
RA   Berriman M., Song J., Olsen R., Szafranski K., Xu Q., Tunggal B.,
RA   Kummerfeld S., Madera M., Konfortov B.A., Rivero F., Bankier A.T.,
RA   Lehmann R., Hamlin N., Davies R., Gaudet P., Fey P., Pilcher K., Chen G.,
RA   Saunders D., Sodergren E.J., Davis P., Kerhornou A., Nie X., Hall N.,
RA   Anjard C., Hemphill L., Bason N., Farbrother P., Desany B., Just E.,
RA   Morio T., Rost R., Churcher C.M., Cooper J., Haydock S., van Driessche N.,
RA   Cronin A., Goodhead I., Muzny D.M., Mourier T., Pain A., Lu M., Harper D.,
RA   Lindsay R., Hauser H., James K.D., Quiles M., Madan Babu M., Saito T.,
RA   Buchrieser C., Wardroper A., Felder M., Thangavelu M., Johnson D.,
RA   Knights A., Loulseged H., Mungall K.L., Oliver K., Price C., Quail M.A.,
RA   Urushihara H., Hernandez J., Rabbinowitsch E., Steffen D., Sanders M.,
RA   Ma J., Kohara Y., Sharp S., Simmonds M.N., Spiegler S., Tivey A.,
RA   Sugano S., White B., Walker D., Woodward J.R., Winckler T., Tanaka Y.,
RA   Shaulsky G., Schleicher M., Weinstock G.M., Rosenthal A., Cox E.C.,
RA   Chisholm R.L., Gibbs R.A., Loomis W.F., Platzer M., Kay R.R.,
RA   Williams J.G., Dear P.H., Noegel A.A., Barrell B.G., Kuspa A.;
RT   "The genome of the social amoeba Dictyostelium discoideum.";
RL   Nature 435:43-57(2005).
CC   -!- FUNCTION: Catalyzes the exchange of eukaryotic initiation factor 2-
CC       bound GDP for GTP. {ECO:0000250}.
CC   -!- SUBUNIT: Complex of five different subunits; alpha, beta, gamma, delta
CC       and epsilon. {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the eIF-2B gamma/epsilon subunits family.
CC       {ECO:0000305}.
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DR   EMBL; AAFI02000166; EAL62097.1; -; Genomic_DNA.
DR   RefSeq; XP_635599.1; XM_630507.1.
DR   AlphaFoldDB; Q54FQ8; -.
DR   SMR; Q54FQ8; -.
DR   STRING; 44689.DDB0234239; -.
DR   PaxDb; Q54FQ8; -.
DR   EnsemblProtists; EAL62097; EAL62097; DDB_G0290693.
DR   GeneID; 8627780; -.
DR   KEGG; ddi:DDB_G0290693; -.
DR   dictyBase; DDB_G0290693; eif2b3.
DR   eggNOG; KOG1462; Eukaryota.
DR   HOGENOM; CLU_016743_0_0_1; -.
DR   InParanoid; Q54FQ8; -.
DR   OMA; LLQAWMV; -.
DR   PhylomeDB; Q54FQ8; -.
DR   Reactome; R-DDI-72731; Recycling of eIF2:GDP.
DR   PRO; PR:Q54FQ8; -.
DR   Proteomes; UP000002195; Chromosome 5.
DR   GO; GO:0005851; C:eukaryotic translation initiation factor 2B complex; IBA:GO_Central.
DR   GO; GO:0032045; C:guanyl-nucleotide exchange factor complex; IBA:GO_Central.
DR   GO; GO:0005085; F:guanyl-nucleotide exchange factor activity; IBA:GO_Central.
DR   GO; GO:0016779; F:nucleotidyltransferase activity; IEA:InterPro.
DR   GO; GO:0003743; F:translation initiation factor activity; IBA:GO_Central.
DR   GO; GO:0002183; P:cytoplasmic translational initiation; IBA:GO_Central.
DR   Gene3D; 3.90.550.10; -; 1.
DR   InterPro; IPR001451; Hexapep.
DR   InterPro; IPR005835; NTP_transferase_dom.
DR   InterPro; IPR029044; Nucleotide-diphossugar_trans.
DR   Pfam; PF00132; Hexapep; 1.
DR   Pfam; PF00483; NTP_transferase; 1.
DR   SUPFAM; SSF53448; SSF53448; 1.
PE   3: Inferred from homology;
KW   Initiation factor; Protein biosynthesis; Reference proteome.
FT   CHAIN           1..440
FT                   /note="Translation initiation factor eIF-2B subunit gamma"
FT                   /id="PRO_0000328030"
SQ   SEQUENCE   440 AA;  50175 MW;  A941E9EF2A6A086D CRC64;
     MTQTQFQVVI LATDKASGNS KLEPIDATIP HSLLPIANRP LISYQLEFLE KAGFETKSEP
     VIIVVNETSQ EKIKQYVSEI YKGKIEVEFF VLKDQLATCE ILYRIRDKIR LEYFMVLNAN
     LVLEDTFIRQ MADLHRKEES SLTVLLKPPT PKVEQKGKGA TETSTKQDKL FTDYIALEEK
     SQKIVMMEPA TEVEEDLNFN KSLLKYFPNV TIYTNLQDTQ LYIFSRWVLD LIIEDQKEKY
     PLFFDIKKHL IPYLLSCQIP NIKRKRALPA SAFNQNQTLS QTMSSTTSPF DQFSELNAQK
     NKTIKCFAHL LKKEGYCMNV NTIKNYQQIN RDIAKGDLQY LPNEPKSEKN FFIDPTANVT
     ITQVGPQCVI GTSTTLGAKC SVKFSIIGKH CKIGDGVRIE NSIIMDHVII EDRCVINSSI
     ICNDVYIKSG SSTVGQYLTK