ID   EI2BG_MACFA             Reviewed;         452 AA.
AC   Q4R6T3;
DT   13-JUN-2006, integrated into UniProtKB/Swiss-Prot.
DT   19-JUL-2005, sequence version 1.
DT   25-MAY-2022, entry version 51.
DE   RecName: Full=Translation initiation factor eIF-2B subunit gamma;
DE   AltName: Full=eIF-2B GDP-GTP exchange factor subunit gamma;
GN   Name=EIF2B3; ORFNames=QtsA-17166;
OS   Macaca fascicularis (Crab-eating macaque) (Cynomolgus monkey).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini;
OC   Cercopithecidae; Cercopithecinae; Macaca.
OX   NCBI_TaxID=9541;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Testis;
RG   International consortium for macaque cDNA sequencing and analysis;
RT   "DNA sequences of macaque genes expressed in brain or testis and its
RT   evolutionary implications.";
RL   Submitted (JUN-2005) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Catalyzes the exchange of eukaryotic initiation factor 2-
CC       bound GDP for GTP. {ECO:0000250}.
CC   -!- SUBUNIT: Complex of five different subunits; alpha, beta, gamma, delta
CC       and epsilon. {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the eIF-2B gamma/epsilon subunits family.
CC       {ECO:0000305}.
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DR   EMBL; AB169097; BAE01191.1; -; mRNA.
DR   AlphaFoldDB; Q4R6T3; -.
DR   SMR; Q4R6T3; -.
DR   STRING; 9541.XP_005543615.1; -.
DR   eggNOG; KOG1462; Eukaryota.
DR   Proteomes; UP000233100; Unplaced.
DR   GO; GO:0005737; C:cytoplasm; ISS:UniProtKB.
DR   GO; GO:0005851; C:eukaryotic translation initiation factor 2B complex; ISS:UniProtKB.
DR   GO; GO:0016779; F:nucleotidyltransferase activity; IEA:InterPro.
DR   GO; GO:0003743; F:translation initiation factor activity; IEA:UniProtKB-KW.
DR   GO; GO:0014003; P:oligodendrocyte development; ISS:UniProtKB.
DR   GO; GO:0050790; P:regulation of catalytic activity; IEA:GOC.
DR   GO; GO:0050852; P:T cell receptor signaling pathway; ISS:UniProtKB.
DR   GO; GO:0006413; P:translational initiation; ISS:UniProtKB.
DR   Gene3D; 3.90.550.10; -; 1.
DR   InterPro; IPR005835; NTP_transferase_dom.
DR   InterPro; IPR029044; Nucleotide-diphossugar_trans.
DR   Pfam; PF00483; NTP_transferase; 1.
DR   SUPFAM; SSF53448; SSF53448; 1.
PE   2: Evidence at transcript level;
KW   Acetylation; Initiation factor; Phosphoprotein; Protein biosynthesis;
KW   Reference proteome.
FT   CHAIN           1..452
FT                   /note="Translation initiation factor eIF-2B subunit gamma"
FT                   /id="PRO_0000239430"
FT   MOD_RES         1
FT                   /note="N-acetylmethionine"
FT                   /evidence="ECO:0000250|UniProtKB:Q9NR50"
FT   MOD_RES         260
FT                   /note="Phosphoserine"
FT                   /evidence="ECO:0000250|UniProtKB:Q9NR50"
SQ   SEQUENCE   452 AA;  50299 MW;  50CFAD2543494D9F CRC64;
     MEFQAVVMAV GGGSRMTDLT SSIPKPLLPA GNKPLIWYPL NLLERVGFEE VIVVTTRDVQ
     KALCAEFKMK MKPDIVCIPD DADMGTADSL RYMYPKLKTD VLVLSCDLIT DVALHEVVDL
     FRAYDASLAM LMRKGQDSLE PVPGQKGKKK AVEQRDFIGV DSTGKRLLFM ANEADLDEEL
     VIKGSILQKY PRIRFHTDLV DAHLYCLKKY VVDFLMENGS ITSIRSELIP YLVRKQFSSA
     SSQQGQEEKE EDLKKKELKS LDIYSFLKEA NTLNLAPYDA CWNACRGDRW EDLPRSQVRC
     YVHIMKEGLC SRVSTLGLYM EANRQVPKLL SALCPEEPLV HSSAQIVSKH LVGVDSLIGP
     ETQIGEKSSI KRSVIGSSCL IKDRVTITNC LLMNSVTVEE GSNIQGSVIC NNAVIEKGAD
     IKDCLIGSGQ RIEAKAKRVN EVIVGSDQLM EI