ID   EI2BG_RAT               Reviewed;         452 AA.
AC   P70541; Q6IN08;
DT   01-NOV-1997, integrated into UniProtKB/Swiss-Prot.
DT   13-JUN-2006, sequence version 2.
DT   03-AUG-2022, entry version 122.
DE   RecName: Full=Translation initiation factor eIF-2B subunit gamma;
DE   AltName: Full=eIF-2B GDP-GTP exchange factor subunit gamma;
GN   Name=Eif2b3; Synonyms=Eif2bg;
OS   Rattus norvegicus (Rat).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC   Murinae; Rattus.
OX   NCBI_TaxID=10116;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RC   STRAIN=Sprague-Dawley; TISSUE=Skeletal muscle;
RX   PubMed=8809057; DOI=10.1042/bj3180631;
RA   Price N.T., Kimball S.R., Jefferson L.S., Proud C.G.;
RT   "Cloning of cDNA for the gamma-subunit of mammalian translation initiation
RT   factor 2B, the guanine nucleotide-exchange factor for eukaryotic initiation
RT   factor 2.";
RL   Biochem. J. 318:631-636(1996).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Lung;
RX   PubMed=15489334; DOI=10.1101/gr.2596504;
RG   The MGC Project Team;
RT   "The status, quality, and expansion of the NIH full-length cDNA project:
RT   the Mammalian Gene Collection (MGC).";
RL   Genome Res. 14:2121-2127(2004).
CC   -!- FUNCTION: Catalyzes the exchange of eukaryotic initiation factor 2-
CC       bound GDP for GTP.
CC   -!- SUBUNIT: Complex of five different subunits; alpha, beta, gamma, delta
CC       and epsilon.
CC   -!- TISSUE SPECIFICITY: Brain, heart, liver, muscle and testis.
CC   -!- SIMILARITY: Belongs to the eIF-2B gamma/epsilon subunits family.
CC       {ECO:0000305}.
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DR   EMBL; U38253; AAC52788.1; -; mRNA.
DR   EMBL; BC072507; AAH72507.1; -; mRNA.
DR   PIR; S72266; S72266.
DR   RefSeq; NP_598293.2; NM_133609.2.
DR   RefSeq; XP_006238692.1; XM_006238630.3.
DR   AlphaFoldDB; P70541; -.
DR   SMR; P70541; -.
DR   BioGRID; 251149; 1.
DR   STRING; 10116.ENSRNOP00000024841; -.
DR   jPOST; P70541; -.
DR   PaxDb; P70541; -.
DR   PRIDE; P70541; -.
DR   Ensembl; ENSRNOT00000097401; ENSRNOP00000088850; ENSRNOG00000018375.
DR   GeneID; 171145; -.
DR   KEGG; rno:171145; -.
DR   UCSC; RGD:620821; rat.
DR   CTD; 8891; -.
DR   RGD; 620821; Eif2b3.
DR   eggNOG; KOG1462; Eukaryota.
DR   GeneTree; ENSGT00510000047486; -.
DR   HOGENOM; CLU_016743_0_0_1; -.
DR   InParanoid; P70541; -.
DR   OMA; LLQAWMV; -.
DR   OrthoDB; 1388750at2759; -.
DR   PhylomeDB; P70541; -.
DR   Reactome; R-RNO-72731; Recycling of eIF2:GDP.
DR   PRO; PR:P70541; -.
DR   Proteomes; UP000002494; Chromosome 5.
DR   Bgee; ENSRNOG00000018375; Expressed in ovary and 20 other tissues.
DR   Genevisible; P70541; RN.
DR   GO; GO:0005737; C:cytoplasm; ISS:UniProtKB.
DR   GO; GO:0005851; C:eukaryotic translation initiation factor 2B complex; IDA:RGD.
DR   GO; GO:0032045; C:guanyl-nucleotide exchange factor complex; IBA:GO_Central.
DR   GO; GO:0005085; F:guanyl-nucleotide exchange factor activity; IDA:RGD.
DR   GO; GO:0016779; F:nucleotidyltransferase activity; IEA:InterPro.
DR   GO; GO:0003743; F:translation initiation factor activity; IBA:GO_Central.
DR   GO; GO:0002183; P:cytoplasmic translational initiation; IBA:GO_Central.
DR   GO; GO:0021766; P:hippocampus development; IEP:RGD.
DR   GO; GO:0014003; P:oligodendrocyte development; ISS:UniProtKB.
DR   GO; GO:0009749; P:response to glucose; IDA:UniProtKB.
DR   GO; GO:0009408; P:response to heat; IDA:UniProtKB.
DR   GO; GO:0043434; P:response to peptide hormone; IDA:UniProtKB.
DR   GO; GO:0050852; P:T cell receptor signaling pathway; ISS:UniProtKB.
DR   GO; GO:0006412; P:translation; TAS:RGD.
DR   GO; GO:0006413; P:translational initiation; ISS:UniProtKB.
DR   Gene3D; 3.90.550.10; -; 1.
DR   InterPro; IPR005835; NTP_transferase_dom.
DR   InterPro; IPR029044; Nucleotide-diphossugar_trans.
DR   Pfam; PF00483; NTP_transferase; 1.
DR   SUPFAM; SSF53448; SSF53448; 1.
PE   2: Evidence at transcript level;
KW   Acetylation; Initiation factor; Phosphoprotein; Protein biosynthesis;
KW   Reference proteome.
FT   CHAIN           1..452
FT                   /note="Translation initiation factor eIF-2B subunit gamma"
FT                   /id="PRO_0000156080"
FT   MOD_RES         1
FT                   /note="N-acetylmethionine"
FT                   /evidence="ECO:0000250|UniProtKB:Q9NR50"
FT   MOD_RES         260
FT                   /note="Phosphoserine"
FT                   /evidence="ECO:0000250|UniProtKB:Q9NR50"
FT   CONFLICT        399
FT                   /note="E -> G (in Ref. 1; AAC52788)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        410
FT                   /note="C -> F (in Ref. 1; AAC52788)"
FT                   /evidence="ECO:0000305"
SQ   SEQUENCE   452 AA;  50435 MW;  BA33492D1700BE4F CRC64;
     MEFQAVVMAV GGGSRMTDLT SSIPKPLLPV GNKPLIWYPL NLLERVGFEE VIVVTTKDVQ
     KALCAEFKMK LKPDIVCIPD EADMGTADSL RHIYPKLKTD VLVLGCDLIT DVALHEVVDL
     FRAYDASLAM LMRKGQESTE PVPGQKGKKK TVEQRDFIGV DSTGKRLLFM ANEADLDEEL
     VIKGSILQKH PRIHFQTGLV DAHLYCLKKY VVDFLMENKS ITSIRSELIP YLVRKQFSSA
     SSQQRQEDKE EDLKKKEPKS LDIYSFIKKD NTLTLAPYDA CWNAFRRDKW EDLSRSQVRC
     YVHIMKEGLC SRVSTLGLYM EANRQVPKLL SVLCPEESMI HPSAQIANKH LIGADSLIGS
     DTQVGEKSSI KRSVIGSSCV IRDRVTVTNC LLMNSVTVEE GSSIHGSVIC NNAVVEAGAE
     IRDCLIGSGQ RIEAKAKRMN EVIVGNDQLM EI