ID   EI3D2_DROAN             Reviewed;         549 AA.
AC   B3LZN3;
DT   10-FEB-2009, integrated into UniProtKB/Swiss-Prot.
DT   02-SEP-2008, sequence version 1.
DT   03-AUG-2022, entry version 58.
DE   RecName: Full=Eukaryotic translation initiation factor 3 subunit D-2 {ECO:0000255|HAMAP-Rule:MF_03003};
DE            Short=eIF3d-2 {ECO:0000255|HAMAP-Rule:MF_03003};
DE   AltName: Full=Eukaryotic translation initiation factor 3 subunit 7-2 {ECO:0000255|HAMAP-Rule:MF_03003};
GN   Name=eIF3d2 {ECO:0000255|HAMAP-Rule:MF_03003};
GN   Synonyms=eIF3-S7-2 {ECO:0000255|HAMAP-Rule:MF_03003}; ORFNames=GF17742;
OS   Drosophila ananassae (Fruit fly).
OC   Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC   Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea;
OC   Drosophilidae; Drosophila; Sophophora.
OX   NCBI_TaxID=7217;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Tucson 14024-0371.13;
RX   PubMed=17994087; DOI=10.1038/nature06341;
RG   Drosophila 12 genomes consortium;
RT   "Evolution of genes and genomes on the Drosophila phylogeny.";
RL   Nature 450:203-218(2007).
CC   -!- FUNCTION: mRNA cap-binding component of the eukaryotic translation
CC       initiation factor 3 (eIF-3) complex, which is involved in protein
CC       synthesis of a specialized repertoire of mRNAs and, together with other
CC       initiation factors, stimulates binding of mRNA and methionyl-tRNAi to
CC       the 40S ribosome. The eIF-3 complex specifically targets and initiates
CC       translation of a subset of mRNAs involved in cell proliferation. In the
CC       eIF-3 complex, eif3d specifically recognizes and binds the 7-
CC       methylguanosine cap of a subset of mRNAs. {ECO:0000255|HAMAP-
CC       Rule:MF_03003}.
CC   -!- SUBUNIT: Component of the eukaryotic translation initiation factor 3
CC       (eIF-3) complex. The eIF-3 complex interacts with pix.
CC       {ECO:0000255|HAMAP-Rule:MF_03003}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000255|HAMAP-Rule:MF_03003}.
CC   -!- DOMAIN: The RNA gate region regulates mRNA cap recognition to prevent
CC       promiscuous mRNA-binding before assembly of eif3d into the full
CC       eukaryotic translation initiation factor 3 (eIF-3) complex.
CC       {ECO:0000255|HAMAP-Rule:MF_03003}.
CC   -!- SIMILARITY: Belongs to the eIF-3 subunit D family. {ECO:0000255|HAMAP-
CC       Rule:MF_03003}.
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DR   EMBL; CH902617; EDV41975.1; -; Genomic_DNA.
DR   RefSeq; XP_001953392.1; XM_001953357.2.
DR   AlphaFoldDB; B3LZN3; -.
DR   SMR; B3LZN3; -.
DR   STRING; 7217.FBpp0120934; -.
DR   PRIDE; B3LZN3; -.
DR   EnsemblMetazoa; FBtr0122442; FBpp0120934; FBgn0094760.
DR   GeneID; 6500525; -.
DR   KEGG; dan:6500525; -.
DR   eggNOG; KOG2479; Eukaryota.
DR   HOGENOM; CLU_024521_2_0_1; -.
DR   InParanoid; B3LZN3; -.
DR   OMA; CKHNGVI; -.
DR   OrthoDB; 1030308at2759; -.
DR   PhylomeDB; B3LZN3; -.
DR   Proteomes; UP000007801; Unassembled WGS sequence.
DR   GO; GO:0016282; C:eukaryotic 43S preinitiation complex; IEA:UniProtKB-UniRule.
DR   GO; GO:0033290; C:eukaryotic 48S preinitiation complex; IEA:UniProtKB-UniRule.
DR   GO; GO:0005852; C:eukaryotic translation initiation factor 3 complex; ISS:UniProtKB.
DR   GO; GO:0098808; F:mRNA cap binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0003743; F:translation initiation factor activity; ISS:UniProtKB.
DR   GO; GO:0002191; P:cap-dependent translational initiation; IEA:UniProtKB-UniRule.
DR   GO; GO:0001732; P:formation of cytoplasmic translation initiation complex; IEA:UniProtKB-UniRule.
DR   GO; GO:0006446; P:regulation of translational initiation; ISS:UniProtKB.
DR   HAMAP; MF_03003; eIF3d; 1.
DR   InterPro; IPR007783; eIF3d.
DR   PANTHER; PTHR12399; PTHR12399; 1.
DR   Pfam; PF05091; eIF-3_zeta; 1.
DR   PIRSF; PIRSF016281; EIF-3_zeta; 1.
PE   3: Inferred from homology;
KW   Cytoplasm; Initiation factor; Protein biosynthesis; Reference proteome;
KW   RNA-binding.
FT   CHAIN           1..549
FT                   /note="Eukaryotic translation initiation factor 3 subunit
FT                   D-2"
FT                   /id="PRO_0000364143"
FT   REGION          107..157
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          288..302
FT                   /note="RNA gate"
FT                   /evidence="ECO:0000250|UniProtKB:K7IM66"
FT   REGION          527..549
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   549 AA;  62182 MW;  017A64F4126D7CA2 CRC64;
     MASYAPFIKP YVQYNEHGWG PCEIPDMDVP YQPFCKSDRL GKICDWTVAM QEKKFSNKYA
     SSFGNNSQYA YFHEDDDSTF HLVDTSGSRA LKPYQRGRFR PNVRNNARVK GRSGRGPGML
     GVAGSMAGGG TTSGSTKYGK GRESRRNQGR RFARNAPSRL RESSVLVRPN WVSLEEIEFP
     RLLKLALPNI KEGQDIVTCG SLEYYDKLYD RINLRNERPL LKMDRIVHTV TTTDDPVIRR
     LSKTMGNVFA TDEILATIMC CTRSNYSWDV VIEKLGTKVF LDKRDNAQFD LLTVNETSLE
     PPMDEEGSIN SAHSLAMEAT LINHNFGQQV LRVGEQEPRF KFGEPNPFEE PGVELACLGY
     RYRQWQLGND LVLVARCKHN GVIQGPNGEV QFLSIKALNE WDSKAANSVE WRQKLDTQRG
     AVLASELRNN ACKLARWTVE AVLAGSDQLK LGYVSRVTPR DHLRHVILGT QQFKPQEFAT
     QINLNMDNAW GILRCLVDIV MKQPDGKYLI VKDPNKPMVR LYDIPENSFD SDAEDEENSS
     EPFANSLDN