ID   EI3D2_DROMO             Reviewed;         554 AA.
AC   B4KDI2;
DT   10-FEB-2009, integrated into UniProtKB/Swiss-Prot.
DT   23-SEP-2008, sequence version 1.
DT   03-AUG-2022, entry version 59.
DE   RecName: Full=Eukaryotic translation initiation factor 3 subunit D-2 {ECO:0000255|HAMAP-Rule:MF_03003};
DE            Short=eIF3d-2 {ECO:0000255|HAMAP-Rule:MF_03003};
DE   AltName: Full=Eukaryotic translation initiation factor 3 subunit 7-2 {ECO:0000255|HAMAP-Rule:MF_03003};
GN   Name=eIF3d2 {ECO:0000255|HAMAP-Rule:MF_03003};
GN   Synonyms=eIF3-S7-2 {ECO:0000255|HAMAP-Rule:MF_03003}; ORFNames=GI22467;
OS   Drosophila mojavensis (Fruit fly).
OC   Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC   Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea;
OC   Drosophilidae; Drosophila.
OX   NCBI_TaxID=7230;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Tucson 15081-1352.22;
RX   PubMed=17994087; DOI=10.1038/nature06341;
RG   Drosophila 12 genomes consortium;
RT   "Evolution of genes and genomes on the Drosophila phylogeny.";
RL   Nature 450:203-218(2007).
CC   -!- FUNCTION: mRNA cap-binding component of the eukaryotic translation
CC       initiation factor 3 (eIF-3) complex, which is involved in protein
CC       synthesis of a specialized repertoire of mRNAs and, together with other
CC       initiation factors, stimulates binding of mRNA and methionyl-tRNAi to
CC       the 40S ribosome. The eIF-3 complex specifically targets and initiates
CC       translation of a subset of mRNAs involved in cell proliferation. In the
CC       eIF-3 complex, eif3d specifically recognizes and binds the 7-
CC       methylguanosine cap of a subset of mRNAs. {ECO:0000255|HAMAP-
CC       Rule:MF_03003}.
CC   -!- SUBUNIT: Component of the eukaryotic translation initiation factor 3
CC       (eIF-3) complex. The eIF-3 complex interacts with pix.
CC       {ECO:0000255|HAMAP-Rule:MF_03003}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000255|HAMAP-Rule:MF_03003}.
CC   -!- DOMAIN: The RNA gate region regulates mRNA cap recognition to prevent
CC       promiscuous mRNA-binding before assembly of eif3d into the full
CC       eukaryotic translation initiation factor 3 (eIF-3) complex.
CC       {ECO:0000255|HAMAP-Rule:MF_03003}.
CC   -!- SIMILARITY: Belongs to the eIF-3 subunit D family. {ECO:0000255|HAMAP-
CC       Rule:MF_03003}.
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DR   EMBL; CH933806; EDW15991.1; -; Genomic_DNA.
DR   RefSeq; XP_002000530.1; XM_002000494.2.
DR   AlphaFoldDB; B4KDI2; -.
DR   SMR; B4KDI2; -.
DR   STRING; 7230.FBpp0171684; -.
DR   EnsemblMetazoa; FBtr0173192; FBpp0171684; FBgn0145195.
DR   GeneID; 6574485; -.
DR   KEGG; dmo:Dmoj_GI22467; -.
DR   eggNOG; KOG2479; Eukaryota.
DR   HOGENOM; CLU_024521_2_0_1; -.
DR   InParanoid; B4KDI2; -.
DR   OMA; CKHNGVI; -.
DR   OrthoDB; 1030308at2759; -.
DR   PhylomeDB; B4KDI2; -.
DR   Proteomes; UP000009192; Unassembled WGS sequence.
DR   GO; GO:0016282; C:eukaryotic 43S preinitiation complex; IEA:UniProtKB-UniRule.
DR   GO; GO:0033290; C:eukaryotic 48S preinitiation complex; IEA:UniProtKB-UniRule.
DR   GO; GO:0005852; C:eukaryotic translation initiation factor 3 complex; ISS:UniProtKB.
DR   GO; GO:0098808; F:mRNA cap binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0003743; F:translation initiation factor activity; ISS:UniProtKB.
DR   GO; GO:0002191; P:cap-dependent translational initiation; IEA:UniProtKB-UniRule.
DR   GO; GO:0001732; P:formation of cytoplasmic translation initiation complex; IEA:UniProtKB-UniRule.
DR   GO; GO:0006446; P:regulation of translational initiation; ISS:UniProtKB.
DR   HAMAP; MF_03003; eIF3d; 1.
DR   InterPro; IPR007783; eIF3d.
DR   PANTHER; PTHR12399; PTHR12399; 1.
DR   Pfam; PF05091; eIF-3_zeta; 1.
DR   PIRSF; PIRSF016281; EIF-3_zeta; 1.
PE   3: Inferred from homology;
KW   Cytoplasm; Initiation factor; Protein biosynthesis; Reference proteome;
KW   RNA-binding.
FT   CHAIN           1..554
FT                   /note="Eukaryotic translation initiation factor 3 subunit
FT                   D-2"
FT                   /id="PRO_0000364151"
FT   REGION          291..305
FT                   /note="RNA gate"
FT                   /evidence="ECO:0000250|UniProtKB:K7IM66"
FT   REGION          530..554
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   554 AA;  62841 MW;  B687E51942CBD243 CRC64;
     MSHYAPFIKP YIEYNQFGWG PCDVSDMEVP YQPFCKSDRL GKISDWMLPV QDKKYTNKYA
     STFGSNNSQY AYFHEDDDAT FHLVDGGNPR ALKPYQRNRY RPNQRNNVRL HGRYVRGNAM
     IGVGQGGIGG SGGAGAGNKY GKGRDMRRGY AGRRFMRNAP VRLRESSVLV RSDWVSIEEI
     DFPRLLKLSL PNIKDGIDIV TCGALEYYDK QCDRINVKNE RPLQKVDRII NVPGTIDDPV
     IRRLSKTMGN VFATDDIIAT LMCCTRSNYS WDIVIEKLGT KVFLDKRDNA QFDLLTVNET
     ALEPPQDSEG SINSPQSLSL EATLINHNFS QQVLKIGDQE PKHKFEEPNP FEEPGVELAS
     VAYRYKQWQL GDDVVLIARC KHNGVIKSPS GELQFVSIKA LNEWDSKAAN SVEWRQKLDS
     QRGAVLASEL RNNACKLAKW TVEAVLAGSD QLKLGYVSRV NRNDHLRHVI LGLQQFKPQE
     FATQINLNMD NAWGVLRCLV DIVLKQPDGK YLIMKDPNKP MIRLYDIPEN AFDSDGNEDE
     ETSEDRPFLK SMAN