ID   EI3D2_DROSE             Reviewed;         550 AA.
AC   B4HHG8;
DT   10-FEB-2009, integrated into UniProtKB/Swiss-Prot.
DT   23-SEP-2008, sequence version 1.
DT   25-MAY-2022, entry version 54.
DE   RecName: Full=Eukaryotic translation initiation factor 3 subunit D-2 {ECO:0000255|HAMAP-Rule:MF_03003};
DE            Short=eIF3d-2 {ECO:0000255|HAMAP-Rule:MF_03003};
DE   AltName: Full=Eukaryotic translation initiation factor 3 subunit 7-2 {ECO:0000255|HAMAP-Rule:MF_03003};
GN   Name=eIF3d2 {ECO:0000255|HAMAP-Rule:MF_03003};
GN   Synonyms=eIF3-S7-2 {ECO:0000255|HAMAP-Rule:MF_03003}; ORFNames=GM26037;
OS   Drosophila sechellia (Fruit fly).
OC   Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC   Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea;
OC   Drosophilidae; Drosophila; Sophophora.
OX   NCBI_TaxID=7238;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Rob3c / Tucson 14021-0248.25;
RX   PubMed=17994087; DOI=10.1038/nature06341;
RG   Drosophila 12 genomes consortium;
RT   "Evolution of genes and genomes on the Drosophila phylogeny.";
RL   Nature 450:203-218(2007).
CC   -!- FUNCTION: mRNA cap-binding component of the eukaryotic translation
CC       initiation factor 3 (eIF-3) complex, which is involved in protein
CC       synthesis of a specialized repertoire of mRNAs and, together with other
CC       initiation factors, stimulates binding of mRNA and methionyl-tRNAi to
CC       the 40S ribosome. The eIF-3 complex specifically targets and initiates
CC       translation of a subset of mRNAs involved in cell proliferation. In the
CC       eIF-3 complex, eif3d specifically recognizes and binds the 7-
CC       methylguanosine cap of a subset of mRNAs. {ECO:0000255|HAMAP-
CC       Rule:MF_03003}.
CC   -!- SUBUNIT: Component of the eukaryotic translation initiation factor 3
CC       (eIF-3) complex. The eIF-3 complex interacts with pix.
CC       {ECO:0000255|HAMAP-Rule:MF_03003}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000255|HAMAP-Rule:MF_03003}.
CC   -!- DOMAIN: The RNA gate region regulates mRNA cap recognition to prevent
CC       promiscuous mRNA-binding before assembly of eif3d into the full
CC       eukaryotic translation initiation factor 3 (eIF-3) complex.
CC       {ECO:0000255|HAMAP-Rule:MF_03003}.
CC   -!- SIMILARITY: Belongs to the eIF-3 subunit D family. {ECO:0000255|HAMAP-
CC       Rule:MF_03003}.
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DR   EMBL; CH480815; EDW42507.1; -; Genomic_DNA.
DR   RefSeq; XP_002031521.1; XM_002031485.1.
DR   AlphaFoldDB; B4HHG8; -.
DR   SMR; B4HHG8; -.
DR   STRING; 7238.B4HHG8; -.
DR   EnsemblMetazoa; FBtr0209022; FBpp0207514; FBgn0180892.
DR   GeneID; 6606723; -.
DR   KEGG; dse:6606723; -.
DR   HOGENOM; CLU_024521_2_0_1; -.
DR   OMA; CKHNGVI; -.
DR   PhylomeDB; B4HHG8; -.
DR   Proteomes; UP000001292; Unassembled WGS sequence.
DR   GO; GO:0016282; C:eukaryotic 43S preinitiation complex; IEA:UniProtKB-UniRule.
DR   GO; GO:0033290; C:eukaryotic 48S preinitiation complex; IEA:UniProtKB-UniRule.
DR   GO; GO:0005852; C:eukaryotic translation initiation factor 3 complex; ISS:UniProtKB.
DR   GO; GO:0098808; F:mRNA cap binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0003743; F:translation initiation factor activity; ISS:UniProtKB.
DR   GO; GO:0002191; P:cap-dependent translational initiation; IEA:UniProtKB-UniRule.
DR   GO; GO:0001732; P:formation of cytoplasmic translation initiation complex; IEA:UniProtKB-UniRule.
DR   GO; GO:0006446; P:regulation of translational initiation; ISS:UniProtKB.
DR   HAMAP; MF_03003; eIF3d; 1.
DR   InterPro; IPR007783; eIF3d.
DR   PANTHER; PTHR12399; PTHR12399; 1.
DR   Pfam; PF05091; eIF-3_zeta; 1.
DR   PIRSF; PIRSF016281; EIF-3_zeta; 1.
PE   3: Inferred from homology;
KW   Cytoplasm; Initiation factor; Protein biosynthesis; Reference proteome;
KW   RNA-binding.
FT   CHAIN           1..550
FT                   /note="Eukaryotic translation initiation factor 3 subunit
FT                   D-2"
FT                   /id="PRO_0000364157"
FT   REGION          108..152
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          290..304
FT                   /note="RNA gate"
FT                   /evidence="ECO:0000250|UniProtKB:K7IM66"
FT   REGION          527..550
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   550 AA;  62691 MW;  443EC14FB6B3D47B CRC64;
     MSNYAPFIKP YVEYNEHGWG PCEVPELDVP YQPFCKSDRL GKICDWTAMV PEKKFPSKYA
     STFGNNSQYA YFYEDDDSTF HLVDTTGSKA TKPYQRGRYR TNMRNNVRTR GRTGRGTPNI
     ASLGGSTAGG ATASTTKYGK GRHTRNTQNV GRRFGRNAPT RIRESSVMVQ SNWVSIEEID
     FPRLLKLALP NIKEGKDIAT CGSLEFYDKL YDRVNLRNEK PLQKMARVVH TVTTTDDPVI
     RRLSRTMGNV FATDEILSTI MCCTRSNYSW DVVVEKLGTK VFLDKRYNDQ FDLLTVNETS
     VEPPMEEEGS INSAHSLAME ATLINHNFSQ QVLRIGDQEQ RFMFEEPNPF EEPGVDLASI
     GYRYRQWDLG NDVVLIARCK HNAVIQGPNG DMQFLSIKAL NEWDSKVTNS VEWRQKLDTQ
     RGAVLASELR NNACKLARWT VEAVLAGSDQ LKLGYVSRMN PRDHLRHVIL GTQQFKPQEF
     ATQINLNMDN SWGVLRCLID LVMKQPDGKY LIMKDPNKPM IRLYDVPENA FDSDRDEEES
     SEPLSNSNDN