EI3D2_DROWI
ID EI3D2_DROWI Reviewed; 550 AA.
AC B4N8Z4;
DT 10-FEB-2009, integrated into UniProtKB/Swiss-Prot.
DT 23-SEP-2008, sequence version 1.
DT 03-AUG-2022, entry version 63.
DE RecName: Full=Eukaryotic translation initiation factor 3 subunit D-2 {ECO:0000255|HAMAP-Rule:MF_03003};
DE Short=eIF3d-2 {ECO:0000255|HAMAP-Rule:MF_03003};
DE AltName: Full=Eukaryotic translation initiation factor 3 subunit 7-2 {ECO:0000255|HAMAP-Rule:MF_03003};
GN Name=eIF3d2 {ECO:0000255|HAMAP-Rule:MF_03003};
GN Synonyms=eIF3-S7-2 {ECO:0000255|HAMAP-Rule:MF_03003}; ORFNames=GK11533;
OS Drosophila willistoni (Fruit fly).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea;
OC Drosophilidae; Drosophila; Sophophora.
OX NCBI_TaxID=7260;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Tucson 14030-0811.24;
RX PubMed=17994087; DOI=10.1038/nature06341;
RG Drosophila 12 genomes consortium;
RT "Evolution of genes and genomes on the Drosophila phylogeny.";
RL Nature 450:203-218(2007).
CC -!- FUNCTION: mRNA cap-binding component of the eukaryotic translation
CC initiation factor 3 (eIF-3) complex, which is involved in protein
CC synthesis of a specialized repertoire of mRNAs and, together with other
CC initiation factors, stimulates binding of mRNA and methionyl-tRNAi to
CC the 40S ribosome. The eIF-3 complex specifically targets and initiates
CC translation of a subset of mRNAs involved in cell proliferation. In the
CC eIF-3 complex, eif3d specifically recognizes and binds the 7-
CC methylguanosine cap of a subset of mRNAs. {ECO:0000255|HAMAP-
CC Rule:MF_03003}.
CC -!- SUBUNIT: Component of the eukaryotic translation initiation factor 3
CC (eIF-3) complex. The eIF-3 complex interacts with pix.
CC {ECO:0000255|HAMAP-Rule:MF_03003}.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000255|HAMAP-Rule:MF_03003}.
CC -!- DOMAIN: The RNA gate region regulates mRNA cap recognition to prevent
CC promiscuous mRNA-binding before assembly of eif3d into the full
CC eukaryotic translation initiation factor 3 (eIF-3) complex.
CC {ECO:0000255|HAMAP-Rule:MF_03003}.
CC -!- SIMILARITY: Belongs to the eIF-3 subunit D family. {ECO:0000255|HAMAP-
CC Rule:MF_03003}.
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DR EMBL; CH964232; EDW80499.1; -; Genomic_DNA.
DR RefSeq; XP_002069513.1; XM_002069477.1.
DR AlphaFoldDB; B4N8Z4; -.
DR SMR; B4N8Z4; -.
DR STRING; 7260.FBpp0240676; -.
DR PRIDE; B4N8Z4; -.
DR EnsemblMetazoa; FBtr0242184; FBpp0240676; FBgn0213544.
DR GeneID; 6648146; -.
DR KEGG; dwi:6648146; -.
DR eggNOG; KOG2479; Eukaryota.
DR HOGENOM; CLU_024521_2_0_1; -.
DR InParanoid; B4N8Z4; -.
DR OMA; CKHNGVI; -.
DR OrthoDB; 1030308at2759; -.
DR PhylomeDB; B4N8Z4; -.
DR Proteomes; UP000007798; Unassembled WGS sequence.
DR GO; GO:0016282; C:eukaryotic 43S preinitiation complex; IEA:UniProtKB-UniRule.
DR GO; GO:0033290; C:eukaryotic 48S preinitiation complex; IEA:UniProtKB-UniRule.
DR GO; GO:0005852; C:eukaryotic translation initiation factor 3 complex; ISS:UniProtKB.
DR GO; GO:0098808; F:mRNA cap binding; IEA:UniProtKB-UniRule.
DR GO; GO:0003743; F:translation initiation factor activity; ISS:UniProtKB.
DR GO; GO:0002191; P:cap-dependent translational initiation; IEA:UniProtKB-UniRule.
DR GO; GO:0001732; P:formation of cytoplasmic translation initiation complex; IEA:UniProtKB-UniRule.
DR GO; GO:0006446; P:regulation of translational initiation; ISS:UniProtKB.
DR HAMAP; MF_03003; eIF3d; 1.
DR InterPro; IPR007783; eIF3d.
DR PANTHER; PTHR12399; PTHR12399; 1.
DR Pfam; PF05091; eIF-3_zeta; 1.
DR PIRSF; PIRSF016281; EIF-3_zeta; 1.
PE 3: Inferred from homology;
KW Cytoplasm; Initiation factor; Phosphoprotein; Protein biosynthesis;
KW Reference proteome; RNA-binding.
FT CHAIN 1..550
FT /note="Eukaryotic translation initiation factor 3 subunit
FT D-2"
FT /id="PRO_0000364163"
FT REGION 97..126
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 287..301
FT /note="RNA gate"
FT /evidence="ECO:0000250|UniProtKB:K7IM66"
FT REGION 530..550
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 550 AA; 63002 MW; B533130B8DAC0F94 CRC64;
MSKNYAPFIK PYMQYNEHGW GPCELDVVDV PYQPFSKSDR LGKITDWTVT QQDKKFTNKY
ASSFGNNNQY AYFHEEDDES FRLVDSVGSK VIKPYQRGRG FRPSVHNNPR NVRNQRGRKG
NAMGNIMGPG LASITQRYGK GRDGRRNQGR KYRNLPARLR ESSVVVQSDW VSVKEIDFPR
LLKLSLPNMK EGEDIVTCGA LDYYDKAYDR VNLKNERTLM KIDRIVHTAT TTDDPIIRRL
SKTMGNVFAT DDILATIMCC TRSNYSWDVV IEKLGTKIFF DKRDNVKFDM LTVNETSQEP
PMDEEGSNNS AHSLSMEATF INHNFSQQVL KMGAEENKFK LAEPNPFEEA GVELASMGYR
YKQWDLGNDI TLVARCKHNG VTQLPNGDMQ FLSIRALNEW DSKAANSIEW RQKLDSQRGA
VLSTELRNNA CKLAKWTVES VLAGSDQLKL GYVSRVSPRD HLRHVILGTQ QFKPQEFATQ
INLNMDNCWG ILRCLIDIIR MQPDGKYLIM KDPNKPMVRI YHIPENAFDS DVSEEEESSE
DKPFGLSMNN
