ID   EI3EA_XENLA             Reviewed;         446 AA.
AC   Q05AY2; Q7ZXA5; Q9I8W7;
DT   03-MAR-2009, integrated into UniProtKB/Swiss-Prot.
DT   14-NOV-2006, sequence version 1.
DT   03-AUG-2022, entry version 72.
DE   RecName: Full=Eukaryotic translation initiation factor 3 subunit E-A {ECO:0000255|HAMAP-Rule:MF_03004};
DE            Short=eIF3e-A {ECO:0000255|HAMAP-Rule:MF_03004};
DE   AltName: Full=Eukaryotic translation initiation factor 3 subunit 6-A {ECO:0000255|HAMAP-Rule:MF_03004};
GN   Name=eif3e-a; Synonyms=eif3s6-a;
OS   Xenopus laevis (African clawed frog).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC   Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Xenopus.
OX   NCBI_TaxID=8355;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RX   PubMed=10504338; DOI=10.1242/jcs.112.19.3331;
RA   Morris-Desbois C., Bochard V., Reynaud C., Jalinot P.;
RT   "Interaction between the Ret finger protein and the Int-6 gene product and
RT   co-localisation into nuclear bodies.";
RL   J. Cell Sci. 112:3331-3342(1999).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Embryo, and Pancreas;
RG   NIH - Xenopus Gene Collection (XGC) project;
RL   Submitted (DEC-2006) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Component of the eukaryotic translation initiation factor 3
CC       (eIF-3) complex, which is involved in protein synthesis of a
CC       specialized repertoire of mRNAs and, together with other initiation
CC       factors, stimulates binding of mRNA and methionyl-tRNAi to the 40S
CC       ribosome. The eIF-3 complex specifically targets and initiates
CC       translation of a subset of mRNAs involved in cell proliferation.
CC       {ECO:0000255|HAMAP-Rule:MF_03004}.
CC   -!- SUBUNIT: Component of the eukaryotic translation initiation factor 3
CC       (eIF-3) complex, which is composed of 13 subunits: eif3a, eif3b, eif3c,
CC       eif3d, eif3e, eif3f, eif3g, eif3h, eif3i, eif3j, eif3k, eif3l and
CC       eif3m. {ECO:0000255|HAMAP-Rule:MF_03004}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000255|HAMAP-Rule:MF_03004}.
CC       Nucleus {ECO:0000255|HAMAP-Rule:MF_03004}.
CC   -!- SIMILARITY: Belongs to the eIF-3 subunit E family. {ECO:0000255|HAMAP-
CC       Rule:MF_03004}.
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DR   EMBL; AF162775; AAF80474.1; -; mRNA.
DR   EMBL; BC045079; AAH45079.1; -; mRNA.
DR   EMBL; BC123116; AAI23117.1; -; mRNA.
DR   EMBL; BC128927; AAI28928.1; -; mRNA.
DR   RefSeq; NP_001082486.1; NM_001089017.1.
DR   AlphaFoldDB; Q05AY2; -.
DR   SMR; Q05AY2; -.
DR   BioGRID; 99835; 2.
DR   IntAct; Q05AY2; 1.
DR   DNASU; 398503; -.
DR   GeneID; 398503; -.
DR   KEGG; xla:398503; -.
DR   CTD; 398503; -.
DR   Xenbase; XB-GENE-946253; eif3e.L.
DR   OrthoDB; 1151808at2759; -.
DR   Proteomes; UP000186698; Chromosome 6L.
DR   Bgee; 398503; Expressed in spleen and 19 other tissues.
DR   GO; GO:0016282; C:eukaryotic 43S preinitiation complex; IEA:UniProtKB-UniRule.
DR   GO; GO:0033290; C:eukaryotic 48S preinitiation complex; IEA:UniProtKB-UniRule.
DR   GO; GO:0005852; C:eukaryotic translation initiation factor 3 complex; ISS:UniProtKB.
DR   GO; GO:0071540; C:eukaryotic translation initiation factor 3 complex, eIF3e; IEA:UniProtKB-UniRule.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0003743; F:translation initiation factor activity; IEA:UniProtKB-UniRule.
DR   GO; GO:0001732; P:formation of cytoplasmic translation initiation complex; IEA:UniProtKB-UniRule.
DR   GO; GO:0006413; P:translational initiation; ISS:UniProtKB.
DR   HAMAP; MF_03004; eIF3e; 1.
DR   InterPro; IPR016650; eIF3e.
DR   InterPro; IPR019010; eIF3e_N.
DR   InterPro; IPR000717; PCI_dom.
DR   InterPro; IPR036390; WH_DNA-bd_sf.
DR   PANTHER; PTHR10317; PTHR10317; 1.
DR   Pfam; PF09440; eIF3_N; 1.
DR   Pfam; PF01399; PCI; 1.
DR   PIRSF; PIRSF016255; eIF3e_su6; 1.
DR   SMART; SM01186; eIF3_N; 1.
DR   SMART; SM00088; PINT; 1.
DR   SUPFAM; SSF46785; SSF46785; 1.
DR   PROSITE; PS50250; PCI; 1.
PE   2: Evidence at transcript level;
KW   Cytoplasm; Initiation factor; Nucleus; Protein biosynthesis;
KW   Reference proteome.
FT   CHAIN           1..446
FT                   /note="Eukaryotic translation initiation factor 3 subunit
FT                   E-A"
FT                   /id="PRO_0000365957"
FT   DOMAIN          222..399
FT                   /note="PCI"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU01185"
SQ   SEQUENCE   446 AA;  52227 MW;  27F5C94D4849A2C4 CRC64;
     MADYDLTTKI AQFLDRHLVF PLLEFLSVKE IYNEKELLHG KLDLLSDTNM VDFAMDVYKN
     LYADKEIPLA LREKRTTVVA QLKQLQAETE PIVKMFEDPE TTRQMQSTRD GRMLFDHLAE
     KHGFRQEYLD TLYRYAKFQY ECGNYSGAAE YLYFFRVLVP STDRNALSSL WGKLASEILM
     QNWDAAMEDL TRLKETIDNN TVSSPLQSLQ HRTWLIHWSL FVFFNHPKGR DNIIDLFLYQ
     PQYLNAIQTM CPHILRYLTT AVITNKDVRK RRQVLKDLVK VIQQESYTYK DPITEFVECL
     YVNFDFDGAQ KKLRECESVL VNDFFLVACL EDFIENARLF IFETFCRIHQ CISISMLADK
     LNMTPEEAER WIVNLIRNAR LDAKIDSKLG HVVMGNNAVS PYQQVIEKTK SLAFRSQMLA
     MNIEKKMNTN SRTEAPTWAA QDSGFY