ID   EI3F1_DROPS             Reviewed;         280 AA.
AC   Q295I4;
DT   03-MAR-2009, integrated into UniProtKB/Swiss-Prot.
DT   04-APR-2006, sequence version 1.
DT   03-AUG-2022, entry version 83.
DE   RecName: Full=Eukaryotic translation initiation factor 3 subunit F-1 {ECO:0000255|HAMAP-Rule:MF_03005};
DE            Short=eIF3f-1 {ECO:0000255|HAMAP-Rule:MF_03005};
DE   AltName: Full=Eukaryotic translation initiation factor 3 subunit 5-1 {ECO:0000255|HAMAP-Rule:MF_03005};
GN   Name=eIF3f1 {ECO:0000255|HAMAP-Rule:MF_03005};
GN   Synonyms=eIF3-S5-1 {ECO:0000255|HAMAP-Rule:MF_03005}; ORFNames=GA22021;
OS   Drosophila pseudoobscura pseudoobscura (Fruit fly).
OC   Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC   Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea;
OC   Drosophilidae; Drosophila; Sophophora.
OX   NCBI_TaxID=46245;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=MV2-25 / Tucson 14011-0121.94;
RX   PubMed=15632085; DOI=10.1101/gr.3059305;
RA   Richards S., Liu Y., Bettencourt B.R., Hradecky P., Letovsky S.,
RA   Nielsen R., Thornton K., Hubisz M.J., Chen R., Meisel R.P., Couronne O.,
RA   Hua S., Smith M.A., Zhang P., Liu J., Bussemaker H.J., van Batenburg M.F.,
RA   Howells S.L., Scherer S.E., Sodergren E., Matthews B.B., Crosby M.A.,
RA   Schroeder A.J., Ortiz-Barrientos D., Rives C.M., Metzker M.L., Muzny D.M.,
RA   Scott G., Steffen D., Wheeler D.A., Worley K.C., Havlak P., Durbin K.J.,
RA   Egan A., Gill R., Hume J., Morgan M.B., Miner G., Hamilton C., Huang Y.,
RA   Waldron L., Verduzco D., Clerc-Blankenburg K.P., Dubchak I., Noor M.A.F.,
RA   Anderson W., White K.P., Clark A.G., Schaeffer S.W., Gelbart W.M.,
RA   Weinstock G.M., Gibbs R.A.;
RT   "Comparative genome sequencing of Drosophila pseudoobscura: chromosomal,
RT   gene, and cis-element evolution.";
RL   Genome Res. 15:1-18(2005).
CC   -!- FUNCTION: Component of the eukaryotic translation initiation factor 3
CC       (eIF-3) complex, which is involved in protein synthesis of a
CC       specialized repertoire of mRNAs and, together with other initiation
CC       factors, stimulates binding of mRNA and methionyl-tRNAi to the 40S
CC       ribosome. The eIF-3 complex specifically targets and initiates
CC       translation of a subset of mRNAs involved in cell proliferation.
CC       {ECO:0000255|HAMAP-Rule:MF_03005}.
CC   -!- SUBUNIT: Component of the eukaryotic translation initiation factor 3
CC       (eIF-3) complex. The eIF-3 complex interacts with pix.
CC       {ECO:0000255|HAMAP-Rule:MF_03005}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000255|HAMAP-Rule:MF_03005}.
CC   -!- SIMILARITY: Belongs to the eIF-3 subunit F family. {ECO:0000255|HAMAP-
CC       Rule:MF_03005}.
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DR   EMBL; CM000070; EAL28728.1; -; Genomic_DNA.
DR   RefSeq; XP_001359578.1; XM_001359541.4.
DR   AlphaFoldDB; Q295I4; -.
DR   SMR; Q295I4; -.
DR   STRING; 7237.FBpp0281377; -.
DR   EnsemblMetazoa; FBtr0282939; FBpp0281377; FBgn0082006.
DR   GeneID; 4802712; -.
DR   KEGG; dpo:Dpse_GA22021; -.
DR   eggNOG; KOG2975; Eukaryota.
DR   HOGENOM; CLU_027018_0_1_1; -.
DR   InParanoid; Q295I4; -.
DR   OMA; MADTDSF; -.
DR   PhylomeDB; Q295I4; -.
DR   Proteomes; UP000001819; Chromosome 2.
DR   Bgee; FBgn0082006; Expressed in female reproductive system and 3 other tissues.
DR   GO; GO:0016282; C:eukaryotic 43S preinitiation complex; IEA:UniProtKB-UniRule.
DR   GO; GO:0033290; C:eukaryotic 48S preinitiation complex; IEA:UniProtKB-UniRule.
DR   GO; GO:0005852; C:eukaryotic translation initiation factor 3 complex; IEA:UniProtKB-UniRule.
DR   GO; GO:0070122; F:isopeptidase activity; IEA:InterPro.
DR   GO; GO:0140492; F:metal-dependent deubiquitinase activity; IEA:InterPro.
DR   GO; GO:0003743; F:translation initiation factor activity; IEA:UniProtKB-UniRule.
DR   GO; GO:0031369; F:translation initiation factor binding; IEA:InterPro.
DR   GO; GO:0001732; P:formation of cytoplasmic translation initiation complex; IEA:UniProtKB-UniRule.
DR   GO; GO:0045747; P:positive regulation of Notch signaling pathway; IEA:EnsemblMetazoa.
DR   CDD; cd08064; MPN_eIF3f; 1.
DR   HAMAP; MF_03005; eIF3f; 1.
DR   InterPro; IPR027531; eIF3f.
DR   InterPro; IPR000555; JAMM/MPN+_dom.
DR   InterPro; IPR037518; MPN.
DR   InterPro; IPR024969; Rpn11/EIF3F_C.
DR   PANTHER; PTHR10540:SF6; PTHR10540:SF6; 1.
DR   Pfam; PF01398; JAB; 1.
DR   Pfam; PF13012; MitMem_reg; 1.
DR   SMART; SM00232; JAB_MPN; 1.
DR   PROSITE; PS50249; MPN; 1.
PE   3: Inferred from homology;
KW   Cytoplasm; Initiation factor; Protein biosynthesis; Reference proteome.
FT   CHAIN           1..280
FT                   /note="Eukaryotic translation initiation factor 3 subunit
FT                   F-1"
FT                   /id="PRO_0000364309"
FT   DOMAIN          8..138
FT                   /note="MPN"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU01182"
SQ   SEQUENCE   280 AA;  31112 MW;  834B93F87610C869 CRC64;
     MSALNLTVRV HPVVLFQVVD AFERRNAESH RVIGTLLGSV EKGVVEVTNC FCVPHKEHDD
     QVEAELSYAL DMYDLNRKVN SNEAVVGWWA TGNDVTNHSS VIHEYYAREC NNPVHLTVDT
     SLQGGRMGLR SYVCIQLGVP GGKTGCMFTP IPVELTSYEP ETFGLKLLQK TVGVAPANRP
     KTVPPMLDLA QISEASTKLQ SLLDLILKYV DDVIAHKVTP DNAVGRQLLD LIHSVPHMSH
     EQFTQMFNAN VRNLLMVITL SQLIKTQLQL NEKLTFLPTA