EI3F1_DROSE
ID EI3F1_DROSE Reviewed; 280 AA.
AC B4I3S1;
DT 03-MAR-2009, integrated into UniProtKB/Swiss-Prot.
DT 23-SEP-2008, sequence version 1.
DT 25-MAY-2022, entry version 66.
DE RecName: Full=Eukaryotic translation initiation factor 3 subunit F-1 {ECO:0000255|HAMAP-Rule:MF_03005};
DE Short=eIF3f-1 {ECO:0000255|HAMAP-Rule:MF_03005};
DE AltName: Full=Eukaryotic translation initiation factor 3 subunit 5-1 {ECO:0000255|HAMAP-Rule:MF_03005};
GN Name=eIF3f1 {ECO:0000255|HAMAP-Rule:MF_03005};
GN Synonyms=eIF3-S5-1 {ECO:0000255|HAMAP-Rule:MF_03005}; ORFNames=GM10688;
OS Drosophila sechellia (Fruit fly).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea;
OC Drosophilidae; Drosophila; Sophophora.
OX NCBI_TaxID=7238;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Rob3c / Tucson 14021-0248.25;
RX PubMed=17994087; DOI=10.1038/nature06341;
RG Drosophila 12 genomes consortium;
RT "Evolution of genes and genomes on the Drosophila phylogeny.";
RL Nature 450:203-218(2007).
CC -!- FUNCTION: Component of the eukaryotic translation initiation factor 3
CC (eIF-3) complex, which is involved in protein synthesis of a
CC specialized repertoire of mRNAs and, together with other initiation
CC factors, stimulates binding of mRNA and methionyl-tRNAi to the 40S
CC ribosome. The eIF-3 complex specifically targets and initiates
CC translation of a subset of mRNAs involved in cell proliferation.
CC {ECO:0000255|HAMAP-Rule:MF_03005}.
CC -!- SUBUNIT: Component of the eukaryotic translation initiation factor 3
CC (eIF-3) complex. The eIF-3 complex interacts with pix.
CC {ECO:0000255|HAMAP-Rule:MF_03005}.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000255|HAMAP-Rule:MF_03005}.
CC -!- SIMILARITY: Belongs to the eIF-3 subunit F family. {ECO:0000255|HAMAP-
CC Rule:MF_03005}.
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DR EMBL; CH480821; EDW54864.1; -; Genomic_DNA.
DR RefSeq; XP_002038327.1; XM_002038291.1.
DR AlphaFoldDB; B4I3S1; -.
DR SMR; B4I3S1; -.
DR STRING; 7238.B4I3S1; -.
DR EnsemblMetazoa; FBtr0193673; FBpp0192165; FBgn0165634.
DR GeneID; 6613858; -.
DR KEGG; dse:6613858; -.
DR HOGENOM; CLU_027018_0_1_1; -.
DR OMA; MADTDSF; -.
DR PhylomeDB; B4I3S1; -.
DR Proteomes; UP000001292; Unassembled WGS sequence.
DR GO; GO:0016282; C:eukaryotic 43S preinitiation complex; IEA:UniProtKB-UniRule.
DR GO; GO:0033290; C:eukaryotic 48S preinitiation complex; IEA:UniProtKB-UniRule.
DR GO; GO:0005852; C:eukaryotic translation initiation factor 3 complex; IEA:UniProtKB-UniRule.
DR GO; GO:0070122; F:isopeptidase activity; IEA:InterPro.
DR GO; GO:0140492; F:metal-dependent deubiquitinase activity; IEA:InterPro.
DR GO; GO:0003743; F:translation initiation factor activity; IEA:UniProtKB-UniRule.
DR GO; GO:0031369; F:translation initiation factor binding; IEA:InterPro.
DR GO; GO:0001732; P:formation of cytoplasmic translation initiation complex; IEA:UniProtKB-UniRule.
DR GO; GO:0045747; P:positive regulation of Notch signaling pathway; IEA:EnsemblMetazoa.
DR CDD; cd08064; MPN_eIF3f; 1.
DR HAMAP; MF_03005; eIF3f; 1.
DR InterPro; IPR027531; eIF3f.
DR InterPro; IPR000555; JAMM/MPN+_dom.
DR InterPro; IPR037518; MPN.
DR InterPro; IPR024969; Rpn11/EIF3F_C.
DR PANTHER; PTHR10540:SF6; PTHR10540:SF6; 1.
DR Pfam; PF01398; JAB; 1.
DR Pfam; PF13012; MitMem_reg; 1.
DR SMART; SM00232; JAB_MPN; 1.
DR PROSITE; PS50249; MPN; 1.
PE 3: Inferred from homology;
KW Cytoplasm; Initiation factor; Protein biosynthesis; Reference proteome.
FT CHAIN 1..280
FT /note="Eukaryotic translation initiation factor 3 subunit
FT F-1"
FT /id="PRO_0000364311"
FT DOMAIN 8..138
FT /note="MPN"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU01182"
SQ SEQUENCE 280 AA; 31105 MW; A860162E65005E57 CRC64;
MSALNLTVRV HPVVLFQVVD AFERRNADSH RVIGTLLGSV DKGVVEVTNC FCVPHKEHDD
QVEAELSYAL DMYDLNRKVN SNESVVGWWA TGNDVTNHSS VIHEYYAREC NNPVHLTVDT
SLQGGRMGLR AYVCIQLGVP GGKSGCMFTP IPVELTSYEP ETFGLKLLQK TVGVSPAHRP
KTVPPMLDLA QISEASTKLQ SLLDLILKYV DDVIAHKVTP DNAVGRQLLD LIHSVPHMTH
EQFTQMFNAN VRNLLLVITL SQLIKTQLQL NEKLTFLPTA