EI3F2_DROME
ID EI3F2_DROME Reviewed; 285 AA.
AC A1Z6K7;
DT 03-MAR-2009, integrated into UniProtKB/Swiss-Prot.
DT 03-MAR-2009, sequence version 2.
DT 03-AUG-2022, entry version 115.
DE RecName: Full=Eukaryotic translation initiation factor 3 subunit F-2 {ECO:0000255|HAMAP-Rule:MF_03005};
DE Short=eIF3f-2 {ECO:0000255|HAMAP-Rule:MF_03005};
DE AltName: Full=Eukaryotic translation initiation factor 3 subunit 5-2 {ECO:0000255|HAMAP-Rule:MF_03005};
GN Name=eIF3f2 {ECO:0000255|HAMAP-Rule:MF_03005};
GN Synonyms=eIF3-S5-2 {ECO:0000255|HAMAP-Rule:MF_03005};
GN ORFNames=CG8335 {ECO:0000312|FlyBase:FBgn0033069};
OS Drosophila melanogaster (Fruit fly).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea;
OC Drosophilidae; Drosophila; Sophophora.
OX NCBI_TaxID=7227;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Berkeley;
RX PubMed=10731132; DOI=10.1126/science.287.5461.2185;
RA Adams M.D., Celniker S.E., Holt R.A., Evans C.A., Gocayne J.D.,
RA Amanatides P.G., Scherer S.E., Li P.W., Hoskins R.A., Galle R.F.,
RA George R.A., Lewis S.E., Richards S., Ashburner M., Henderson S.N.,
RA Sutton G.G., Wortman J.R., Yandell M.D., Zhang Q., Chen L.X., Brandon R.C.,
RA Rogers Y.-H.C., Blazej R.G., Champe M., Pfeiffer B.D., Wan K.H., Doyle C.,
RA Baxter E.G., Helt G., Nelson C.R., Miklos G.L.G., Abril J.F., Agbayani A.,
RA An H.-J., Andrews-Pfannkoch C., Baldwin D., Ballew R.M., Basu A.,
RA Baxendale J., Bayraktaroglu L., Beasley E.M., Beeson K.Y., Benos P.V.,
RA Berman B.P., Bhandari D., Bolshakov S., Borkova D., Botchan M.R., Bouck J.,
RA Brokstein P., Brottier P., Burtis K.C., Busam D.A., Butler H., Cadieu E.,
RA Center A., Chandra I., Cherry J.M., Cawley S., Dahlke C., Davenport L.B.,
RA Davies P., de Pablos B., Delcher A., Deng Z., Mays A.D., Dew I.,
RA Dietz S.M., Dodson K., Doup L.E., Downes M., Dugan-Rocha S., Dunkov B.C.,
RA Dunn P., Durbin K.J., Evangelista C.C., Ferraz C., Ferriera S.,
RA Fleischmann W., Fosler C., Gabrielian A.E., Garg N.S., Gelbart W.M.,
RA Glasser K., Glodek A., Gong F., Gorrell J.H., Gu Z., Guan P., Harris M.,
RA Harris N.L., Harvey D.A., Heiman T.J., Hernandez J.R., Houck J., Hostin D.,
RA Houston K.A., Howland T.J., Wei M.-H., Ibegwam C., Jalali M., Kalush F.,
RA Karpen G.H., Ke Z., Kennison J.A., Ketchum K.A., Kimmel B.E., Kodira C.D.,
RA Kraft C.L., Kravitz S., Kulp D., Lai Z., Lasko P., Lei Y., Levitsky A.A.,
RA Li J.H., Li Z., Liang Y., Lin X., Liu X., Mattei B., McIntosh T.C.,
RA McLeod M.P., McPherson D., Merkulov G., Milshina N.V., Mobarry C.,
RA Morris J., Moshrefi A., Mount S.M., Moy M., Murphy B., Murphy L.,
RA Muzny D.M., Nelson D.L., Nelson D.R., Nelson K.A., Nixon K., Nusskern D.R.,
RA Pacleb J.M., Palazzolo M., Pittman G.S., Pan S., Pollard J., Puri V.,
RA Reese M.G., Reinert K., Remington K., Saunders R.D.C., Scheeler F.,
RA Shen H., Shue B.C., Siden-Kiamos I., Simpson M., Skupski M.P., Smith T.J.,
RA Spier E., Spradling A.C., Stapleton M., Strong R., Sun E., Svirskas R.,
RA Tector C., Turner R., Venter E., Wang A.H., Wang X., Wang Z.-Y.,
RA Wassarman D.A., Weinstock G.M., Weissenbach J., Williams S.M., Woodage T.,
RA Worley K.C., Wu D., Yang S., Yao Q.A., Ye J., Yeh R.-F., Zaveri J.S.,
RA Zhan M., Zhang G., Zhao Q., Zheng L., Zheng X.H., Zhong F.N., Zhong W.,
RA Zhou X., Zhu S.C., Zhu X., Smith H.O., Gibbs R.A., Myers E.W., Rubin G.M.,
RA Venter J.C.;
RT "The genome sequence of Drosophila melanogaster.";
RL Science 287:2185-2195(2000).
RN [2]
RP GENOME REANNOTATION.
RC STRAIN=Berkeley;
RX PubMed=12537572; DOI=10.1186/gb-2002-3-12-research0083;
RA Misra S., Crosby M.A., Mungall C.J., Matthews B.B., Campbell K.S.,
RA Hradecky P., Huang Y., Kaminker J.S., Millburn G.H., Prochnik S.E.,
RA Smith C.D., Tupy J.L., Whitfield E.J., Bayraktaroglu L., Berman B.P.,
RA Bettencourt B.R., Celniker S.E., de Grey A.D.N.J., Drysdale R.A.,
RA Harris N.L., Richter J., Russo S., Schroeder A.J., Shu S.Q., Stapleton M.,
RA Yamada C., Ashburner M., Gelbart W.M., Rubin G.M., Lewis S.E.;
RT "Annotation of the Drosophila melanogaster euchromatic genome: a systematic
RT review.";
RL Genome Biol. 3:RESEARCH0083.1-RESEARCH0083.22(2002).
CC -!- FUNCTION: Component of the eukaryotic translation initiation factor 3
CC (eIF-3) complex, which is involved in protein synthesis of a
CC specialized repertoire of mRNAs and, together with other initiation
CC factors, stimulates binding of mRNA and methionyl-tRNAi to the 40S
CC ribosome. The eIF-3 complex specifically targets and initiates
CC translation of a subset of mRNAs involved in cell proliferation.
CC {ECO:0000255|HAMAP-Rule:MF_03005}.
CC -!- SUBUNIT: Component of the eukaryotic translation initiation factor 3
CC (eIF-3) complex. The eIF-3 complex interacts with pix.
CC {ECO:0000255|HAMAP-Rule:MF_03005}.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000255|HAMAP-Rule:MF_03005}.
CC -!- SIMILARITY: Belongs to the eIF-3 subunit F family. {ECO:0000255|HAMAP-
CC Rule:MF_03005}.
CC -!- SEQUENCE CAUTION:
CC Sequence=AAF57273.2; Type=Erroneous initiation; Evidence={ECO:0000305};
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DR EMBL; AE013599; AAF57273.2; ALT_INIT; Genomic_DNA.
DR RefSeq; NP_610210.2; NM_136366.3.
DR AlphaFoldDB; A1Z6K7; -.
DR SMR; A1Z6K7; -.
DR BioGRID; 61450; 3.
DR IntAct; A1Z6K7; 2.
DR STRING; 7227.FBpp0085334; -.
DR PaxDb; A1Z6K7; -.
DR PRIDE; A1Z6K7; -.
DR DNASU; 35547; -.
DR EnsemblMetazoa; FBtr0085990; FBpp0085334; FBgn0033069.
DR GeneID; 35547; -.
DR KEGG; dme:Dmel_CG8335; -.
DR UCSC; CG8335-RA; d. melanogaster.
DR CTD; 35547; -.
DR FlyBase; FBgn0033069; eIF3f2.
DR VEuPathDB; VectorBase:FBgn0033069; -.
DR eggNOG; KOG2975; Eukaryota.
DR HOGENOM; CLU_027018_0_2_1; -.
DR InParanoid; A1Z6K7; -.
DR OMA; IEITNCF; -.
DR OrthoDB; 1038775at2759; -.
DR PhylomeDB; A1Z6K7; -.
DR BioGRID-ORCS; 35547; 0 hits in 1 CRISPR screen.
DR GenomeRNAi; 35547; -.
DR PRO; PR:A1Z6K7; -.
DR Proteomes; UP000000803; Chromosome 2R.
DR Bgee; FBgn0033069; Expressed in testis and 8 other tissues.
DR ExpressionAtlas; A1Z6K7; baseline and differential.
DR Genevisible; A1Z6K7; DM.
DR GO; GO:0016282; C:eukaryotic 43S preinitiation complex; IEA:UniProtKB-UniRule.
DR GO; GO:0033290; C:eukaryotic 48S preinitiation complex; IEA:UniProtKB-UniRule.
DR GO; GO:0005852; C:eukaryotic translation initiation factor 3 complex; ISS:FlyBase.
DR GO; GO:0071541; C:eukaryotic translation initiation factor 3 complex, eIF3m; IBA:GO_Central.
DR GO; GO:0070122; F:isopeptidase activity; IEA:InterPro.
DR GO; GO:0140492; F:metal-dependent deubiquitinase activity; ISS:FlyBase.
DR GO; GO:0003743; F:translation initiation factor activity; ISS:FlyBase.
DR GO; GO:0031369; F:translation initiation factor binding; IBA:GO_Central.
DR GO; GO:0001732; P:formation of cytoplasmic translation initiation complex; IEA:UniProtKB-UniRule.
DR GO; GO:0016579; P:protein deubiquitination; ISS:FlyBase.
DR GO; GO:0006413; P:translational initiation; ISS:FlyBase.
DR CDD; cd08064; MPN_eIF3f; 1.
DR HAMAP; MF_03005; eIF3f; 1.
DR InterPro; IPR027531; eIF3f.
DR InterPro; IPR000555; JAMM/MPN+_dom.
DR InterPro; IPR037518; MPN.
DR InterPro; IPR024969; Rpn11/EIF3F_C.
DR PANTHER; PTHR10540:SF6; PTHR10540:SF6; 1.
DR Pfam; PF01398; JAB; 1.
DR Pfam; PF13012; MitMem_reg; 1.
DR SMART; SM00232; JAB_MPN; 1.
DR PROSITE; PS50249; MPN; 1.
PE 3: Inferred from homology;
KW Cytoplasm; Initiation factor; Protein biosynthesis; Reference proteome.
FT CHAIN 1..285
FT /note="Eukaryotic translation initiation factor 3 subunit
FT F-2"
FT /id="PRO_0000364304"
FT DOMAIN 11..145
FT /note="MPN"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU01182"
SQ SEQUENCE 285 AA; 32561 MW; 73A57167EBB4ACC6 CRC64;
MSRNFSMRAK VYLKPLVFFQ IIDAYDRRPK GDNQVMGTLL GRNKEGHIEI TNCFTVPHKE
HSENKRIDLD MAYASEVLEL NMFAYPNERV LGWFCTGKSV SRSASLIHDY YVRECCEGQP
LHLLVDAALK NQRLSTRLYC AVEMGVPGGT KGLMFSLVPL EISNENSDLV ALRCIEKQSQ
QQASKQMERF VPELAQVVDA TRDMQHRLDL VLRYINDVLA RKKKPDNVVG RSLYAALTAV
PLLDSDKFRV MFNTNLRDML MAITLSTMIK TQLEISEKLS CMQDQ
