EI3F2_DROPS
ID EI3F2_DROPS Reviewed; 288 AA.
AC B5E1N0;
DT 03-MAR-2009, integrated into UniProtKB/Swiss-Prot.
DT 14-OCT-2008, sequence version 1.
DT 03-AUG-2022, entry version 59.
DE RecName: Full=Eukaryotic translation initiation factor 3 subunit F-2 {ECO:0000255|HAMAP-Rule:MF_03005};
DE Short=eIF3f-2 {ECO:0000255|HAMAP-Rule:MF_03005};
DE AltName: Full=Eukaryotic translation initiation factor 3 subunit 5-2 {ECO:0000255|HAMAP-Rule:MF_03005};
GN Name=eIF3f2 {ECO:0000255|HAMAP-Rule:MF_03005};
GN Synonyms=eIF3-S5-2 {ECO:0000255|HAMAP-Rule:MF_03005}; ORFNames=GA25107;
OS Drosophila pseudoobscura pseudoobscura (Fruit fly).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea;
OC Drosophilidae; Drosophila; Sophophora.
OX NCBI_TaxID=46245;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=MV2-25 / Tucson 14011-0121.94;
RX PubMed=15632085; DOI=10.1101/gr.3059305;
RA Richards S., Liu Y., Bettencourt B.R., Hradecky P., Letovsky S.,
RA Nielsen R., Thornton K., Hubisz M.J., Chen R., Meisel R.P., Couronne O.,
RA Hua S., Smith M.A., Zhang P., Liu J., Bussemaker H.J., van Batenburg M.F.,
RA Howells S.L., Scherer S.E., Sodergren E., Matthews B.B., Crosby M.A.,
RA Schroeder A.J., Ortiz-Barrientos D., Rives C.M., Metzker M.L., Muzny D.M.,
RA Scott G., Steffen D., Wheeler D.A., Worley K.C., Havlak P., Durbin K.J.,
RA Egan A., Gill R., Hume J., Morgan M.B., Miner G., Hamilton C., Huang Y.,
RA Waldron L., Verduzco D., Clerc-Blankenburg K.P., Dubchak I., Noor M.A.F.,
RA Anderson W., White K.P., Clark A.G., Schaeffer S.W., Gelbart W.M.,
RA Weinstock G.M., Gibbs R.A.;
RT "Comparative genome sequencing of Drosophila pseudoobscura: chromosomal,
RT gene, and cis-element evolution.";
RL Genome Res. 15:1-18(2005).
CC -!- FUNCTION: Component of the eukaryotic translation initiation factor 3
CC (eIF-3) complex, which is involved in protein synthesis of a
CC specialized repertoire of mRNAs and, together with other initiation
CC factors, stimulates binding of mRNA and methionyl-tRNAi to the 40S
CC ribosome. The eIF-3 complex specifically targets and initiates
CC translation of a subset of mRNAs involved in cell proliferation.
CC {ECO:0000255|HAMAP-Rule:MF_03005}.
CC -!- SUBUNIT: Component of the eukaryotic translation initiation factor 3
CC (eIF-3) complex. The eIF-3 complex interacts with pix.
CC {ECO:0000255|HAMAP-Rule:MF_03005}.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000255|HAMAP-Rule:MF_03005}.
CC -!- SIMILARITY: Belongs to the eIF-3 subunit F family. {ECO:0000255|HAMAP-
CC Rule:MF_03005}.
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DR EMBL; CM000071; EDY69533.1; -; Genomic_DNA.
DR RefSeq; XP_002138975.1; XM_002138939.2.
DR AlphaFoldDB; B5E1N0; -.
DR SMR; B5E1N0; -.
DR STRING; 7237.FBpp0278717; -.
DR EnsemblMetazoa; FBtr0280279; FBpp0278717; FBgn0246490.
DR GeneID; 6899050; -.
DR KEGG; dpo:Dpse_GA25107; -.
DR eggNOG; KOG2975; Eukaryota.
DR HOGENOM; CLU_027018_0_1_1; -.
DR InParanoid; B5E1N0; -.
DR OMA; IEITNCF; -.
DR Proteomes; UP000001819; Chromosome 3.
DR Bgee; FBgn0246490; Expressed in male reproductive system and 2 other tissues.
DR GO; GO:0016282; C:eukaryotic 43S preinitiation complex; IEA:UniProtKB-UniRule.
DR GO; GO:0033290; C:eukaryotic 48S preinitiation complex; IEA:UniProtKB-UniRule.
DR GO; GO:0005852; C:eukaryotic translation initiation factor 3 complex; IEA:UniProtKB-UniRule.
DR GO; GO:0070122; F:isopeptidase activity; IEA:InterPro.
DR GO; GO:0140492; F:metal-dependent deubiquitinase activity; IEA:InterPro.
DR GO; GO:0003743; F:translation initiation factor activity; IEA:UniProtKB-UniRule.
DR GO; GO:0031369; F:translation initiation factor binding; IEA:InterPro.
DR GO; GO:0001732; P:formation of cytoplasmic translation initiation complex; IEA:UniProtKB-UniRule.
DR CDD; cd08064; MPN_eIF3f; 1.
DR HAMAP; MF_03005; eIF3f; 1.
DR InterPro; IPR027531; eIF3f.
DR InterPro; IPR000555; JAMM/MPN+_dom.
DR InterPro; IPR037518; MPN.
DR InterPro; IPR024969; Rpn11/EIF3F_C.
DR PANTHER; PTHR10540:SF6; PTHR10540:SF6; 1.
DR Pfam; PF01398; JAB; 1.
DR Pfam; PF13012; MitMem_reg; 1.
DR SMART; SM00232; JAB_MPN; 1.
DR PROSITE; PS50249; MPN; 1.
PE 3: Inferred from homology;
KW Cytoplasm; Initiation factor; Protein biosynthesis; Reference proteome.
FT CHAIN 1..288
FT /note="Eukaryotic translation initiation factor 3 subunit
FT F-2"
FT /id="PRO_0000364310"
FT DOMAIN 12..149
FT /note="MPN"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU01182"
SQ SEQUENCE 288 AA; 32555 MW; 33643B46E9759A55 CRC64;
MSLSNFNLQS KVLLHPLVLF QIIDAYERRA KDVPEVLGTL LGTVAGKTGR IEITNCFSVV
HRMHGDNNCH IDLDLKYDND MLELAQIAYP QEKVLGWFST GKSVSAAAVE LHEYYERQCH
NGQPLHLLMD TSLRGQRMNT RIFCAVATGV PGGTKGLMFS LLPMDIYFGS PDIVAMRHMG
RQCAQPTKDA GRLLPELEQV VDATKDIQQK LDLVLRYIND ILNRKRRPDN TVGRALHDVL
TSVPMVEAER FRHMFNTNMR DLLMSLTLSS MIKTQLQLSE RLSNMVDA
