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EI3F2_DROSI
ID   EI3F2_DROSI             Reviewed;         285 AA.
AC   B4QD77;
DT   03-MAR-2009, integrated into UniProtKB/Swiss-Prot.
DT   23-SEP-2008, sequence version 1.
DT   03-AUG-2022, entry version 62.
DE   RecName: Full=Eukaryotic translation initiation factor 3 subunit F-2 {ECO:0000255|HAMAP-Rule:MF_03005};
DE            Short=eIF3f-2 {ECO:0000255|HAMAP-Rule:MF_03005};
DE   AltName: Full=Eukaryotic translation initiation factor 3 subunit 5-2 {ECO:0000255|HAMAP-Rule:MF_03005};
GN   Name=eIF3f2 {ECO:0000255|HAMAP-Rule:MF_03005};
GN   Synonyms=eIF3-S5-2 {ECO:0000255|HAMAP-Rule:MF_03005}; ORFNames=GD10400;
OS   Drosophila simulans (Fruit fly).
OC   Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC   Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea;
OC   Drosophilidae; Drosophila; Sophophora.
OX   NCBI_TaxID=7240;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=17994087; DOI=10.1038/nature06341;
RG   Drosophila 12 genomes consortium;
RT   "Evolution of genes and genomes on the Drosophila phylogeny.";
RL   Nature 450:203-218(2007).
CC   -!- FUNCTION: Component of the eukaryotic translation initiation factor 3
CC       (eIF-3) complex, which is involved in protein synthesis of a
CC       specialized repertoire of mRNAs and, together with other initiation
CC       factors, stimulates binding of mRNA and methionyl-tRNAi to the 40S
CC       ribosome. The eIF-3 complex specifically targets and initiates
CC       translation of a subset of mRNAs involved in cell proliferation.
CC       {ECO:0000255|HAMAP-Rule:MF_03005}.
CC   -!- SUBUNIT: Component of the eukaryotic translation initiation factor 3
CC       (eIF-3) complex. The eIF-3 complex interacts with pix.
CC       {ECO:0000255|HAMAP-Rule:MF_03005}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000255|HAMAP-Rule:MF_03005}.
CC   -!- SIMILARITY: Belongs to the eIF-3 subunit F family. {ECO:0000255|HAMAP-
CC       Rule:MF_03005}.
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DR   EMBL; CM000362; EDX05864.1; -; Genomic_DNA.
DR   AlphaFoldDB; B4QD77; -.
DR   SMR; B4QD77; -.
DR   STRING; 7240.B4QD77; -.
DR   PRIDE; B4QD77; -.
DR   EnsemblMetazoa; FBtr0210310; FBpp0208802; FBgn0182171.
DR   HOGENOM; CLU_027018_0_2_1; -.
DR   OMA; IEITNCF; -.
DR   PhylomeDB; B4QD77; -.
DR   Proteomes; UP000000304; Chromosome 2r.
DR   Bgee; FBgn0182171; Expressed in male reproductive system and 3 other tissues.
DR   GO; GO:0016282; C:eukaryotic 43S preinitiation complex; IEA:UniProtKB-UniRule.
DR   GO; GO:0033290; C:eukaryotic 48S preinitiation complex; IEA:UniProtKB-UniRule.
DR   GO; GO:0005852; C:eukaryotic translation initiation factor 3 complex; IEA:UniProtKB-UniRule.
DR   GO; GO:0070122; F:isopeptidase activity; IEA:InterPro.
DR   GO; GO:0140492; F:metal-dependent deubiquitinase activity; IEA:InterPro.
DR   GO; GO:0003743; F:translation initiation factor activity; IEA:UniProtKB-UniRule.
DR   GO; GO:0031369; F:translation initiation factor binding; IEA:InterPro.
DR   GO; GO:0001732; P:formation of cytoplasmic translation initiation complex; IEA:UniProtKB-UniRule.
DR   CDD; cd08064; MPN_eIF3f; 1.
DR   HAMAP; MF_03005; eIF3f; 1.
DR   InterPro; IPR027531; eIF3f.
DR   InterPro; IPR000555; JAMM/MPN+_dom.
DR   InterPro; IPR037518; MPN.
DR   InterPro; IPR024969; Rpn11/EIF3F_C.
DR   PANTHER; PTHR10540:SF6; PTHR10540:SF6; 1.
DR   Pfam; PF01398; JAB; 1.
DR   Pfam; PF13012; MitMem_reg; 1.
DR   SMART; SM00232; JAB_MPN; 1.
DR   PROSITE; PS50249; MPN; 1.
PE   3: Inferred from homology;
KW   Cytoplasm; Initiation factor; Protein biosynthesis; Reference proteome.
FT   CHAIN           1..285
FT                   /note="Eukaryotic translation initiation factor 3 subunit
FT                   F-2"
FT                   /id="PRO_0000364314"
FT   DOMAIN          11..145
FT                   /note="MPN"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU01182"
SQ   SEQUENCE   285 AA;  32619 MW;  0254AD7005A03690 CRC64;
     MSRNLSMRAK VFLKPLVLFQ IIDAYDRRPK GDNQVMGTLL GRNKEDHIEI TNCFTVPHKE
     HSENKRIDLD MTYASEVLEL NMFAYPNERV LGWFCTGKSV SRSASLIHDY YVRECGERQP
     LHLLVDASLK NQRLSTRLYC AVEMGVPGGT KGLMFSLVPL EISSENSDLL AMRCIEKQSQ
     QQASKQMERF APELVQVVDA TRDIQQRLDL LLRYINDVLA RKKKPDNVVG RSLQAALTAV
     PLLDSEKFRL MFNTNLRDML MAITLSTMIK TQLEISEKLS CMQDQ
 
 
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