EI3F2_DROWI
ID EI3F2_DROWI Reviewed; 286 AA.
AC B4MR33;
DT 03-MAR-2009, integrated into UniProtKB/Swiss-Prot.
DT 23-SEP-2008, sequence version 1.
DT 25-MAY-2022, entry version 63.
DE RecName: Full=Eukaryotic translation initiation factor 3 subunit F-2 {ECO:0000255|HAMAP-Rule:MF_03005};
DE Short=eIF3f-2 {ECO:0000255|HAMAP-Rule:MF_03005};
DE AltName: Full=Eukaryotic translation initiation factor 3 subunit 5-2 {ECO:0000255|HAMAP-Rule:MF_03005};
GN Name=eIF3f2 {ECO:0000255|HAMAP-Rule:MF_03005};
GN Synonyms=eIF3-S5-2 {ECO:0000255|HAMAP-Rule:MF_03005}; ORFNames=GK21334;
OS Drosophila willistoni (Fruit fly).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea;
OC Drosophilidae; Drosophila; Sophophora.
OX NCBI_TaxID=7260;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Tucson 14030-0811.24;
RX PubMed=17994087; DOI=10.1038/nature06341;
RG Drosophila 12 genomes consortium;
RT "Evolution of genes and genomes on the Drosophila phylogeny.";
RL Nature 450:203-218(2007).
CC -!- FUNCTION: Component of the eukaryotic translation initiation factor 3
CC (eIF-3) complex, which is involved in protein synthesis of a
CC specialized repertoire of mRNAs and, together with other initiation
CC factors, stimulates binding of mRNA and methionyl-tRNAi to the 40S
CC ribosome. The eIF-3 complex specifically targets and initiates
CC translation of a subset of mRNAs involved in cell proliferation.
CC {ECO:0000255|HAMAP-Rule:MF_03005}.
CC -!- SUBUNIT: Component of the eukaryotic translation initiation factor 3
CC (eIF-3) complex. The eIF-3 complex interacts with pix.
CC {ECO:0000255|HAMAP-Rule:MF_03005}.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000255|HAMAP-Rule:MF_03005}.
CC -!- SIMILARITY: Belongs to the eIF-3 subunit F family. {ECO:0000255|HAMAP-
CC Rule:MF_03005}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; CH963849; EDW74572.1; -; Genomic_DNA.
DR RefSeq; XP_002063586.1; XM_002063550.1.
DR AlphaFoldDB; B4MR33; -.
DR SMR; B4MR33; -.
DR STRING; 7260.FBpp0250477; -.
DR EnsemblMetazoa; FBtr0251985; FBpp0250477; FBgn0223326.
DR GeneID; 6639918; -.
DR KEGG; dwi:6639918; -.
DR eggNOG; KOG2975; Eukaryota.
DR HOGENOM; CLU_027018_0_1_1; -.
DR InParanoid; B4MR33; -.
DR OMA; IEITNCF; -.
DR OrthoDB; 1038775at2759; -.
DR PhylomeDB; B4MR33; -.
DR Proteomes; UP000007798; Unassembled WGS sequence.
DR GO; GO:0016282; C:eukaryotic 43S preinitiation complex; IEA:UniProtKB-UniRule.
DR GO; GO:0033290; C:eukaryotic 48S preinitiation complex; IEA:UniProtKB-UniRule.
DR GO; GO:0005852; C:eukaryotic translation initiation factor 3 complex; IEA:UniProtKB-UniRule.
DR GO; GO:0070122; F:isopeptidase activity; IEA:InterPro.
DR GO; GO:0140492; F:metal-dependent deubiquitinase activity; IEA:InterPro.
DR GO; GO:0003743; F:translation initiation factor activity; IEA:UniProtKB-UniRule.
DR GO; GO:0031369; F:translation initiation factor binding; IEA:InterPro.
DR GO; GO:0001732; P:formation of cytoplasmic translation initiation complex; IEA:UniProtKB-UniRule.
DR CDD; cd08064; MPN_eIF3f; 1.
DR HAMAP; MF_03005; eIF3f; 1.
DR InterPro; IPR027531; eIF3f.
DR InterPro; IPR000555; JAMM/MPN+_dom.
DR InterPro; IPR037518; MPN.
DR InterPro; IPR024969; Rpn11/EIF3F_C.
DR PANTHER; PTHR10540:SF6; PTHR10540:SF6; 1.
DR Pfam; PF01398; JAB; 1.
DR Pfam; PF13012; MitMem_reg; 1.
DR SMART; SM00232; JAB_MPN; 1.
DR PROSITE; PS50249; MPN; 1.
PE 3: Inferred from homology;
KW Cytoplasm; Initiation factor; Protein biosynthesis; Reference proteome.
FT CHAIN 1..286
FT /note="Eukaryotic translation initiation factor 3 subunit
FT F-2"
FT /id="PRO_0000364318"
FT DOMAIN 11..147
FT /note="MPN"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU01182"
SQ SEQUENCE 286 AA; 32350 MW; 0283A379C4844C65 CRC64;
MQAEFKLRSK ILLQPLVLLH IIDAYERRPK DCTQVIGTLL GRNNPESGHL EISNCFTLLH
KDYPNSDRID VDLQYANDMY ELNQLTYPQE KIIGWYATGK EVSRSAVNLH EYYARECADG
NPMHLLIDTS LRGQRMMMRL YTAVVMGVPN GTKGLMFSLL PVEMSSGNPE SVALNLMKKN
ALQPTKQVGR ILPELVQVVD ITRDLQTKLD LVLRYVNETL ARKRTPNNTV GRALHDALTS
VPLVDAESFR MMFNANVRDM LMSITLATMI KAQLKISESV IAMPDL