ID   EI3F2_DROYA             Reviewed;         285 AA.
AC   B4NYU1;
DT   03-MAR-2009, integrated into UniProtKB/Swiss-Prot.
DT   03-MAR-2009, sequence version 2.
DT   25-MAY-2022, entry version 61.
DE   RecName: Full=Eukaryotic translation initiation factor 3 subunit F-2 {ECO:0000255|HAMAP-Rule:MF_03005};
DE            Short=eIF3f-2 {ECO:0000255|HAMAP-Rule:MF_03005};
DE   AltName: Full=Eukaryotic translation initiation factor 3 subunit 5-2 {ECO:0000255|HAMAP-Rule:MF_03005};
GN   Name=eIF3f2 {ECO:0000255|HAMAP-Rule:MF_03005};
GN   Synonyms=eIF3-S5-2 {ECO:0000255|HAMAP-Rule:MF_03005}; ORFNames=GE20747;
OS   Drosophila yakuba (Fruit fly).
OC   Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC   Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea;
OC   Drosophilidae; Drosophila; Sophophora.
OX   NCBI_TaxID=7245;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Tai18E2 / Tucson 14021-0261.01;
RX   PubMed=17994087; DOI=10.1038/nature06341;
RG   Drosophila 12 genomes consortium;
RT   "Evolution of genes and genomes on the Drosophila phylogeny.";
RL   Nature 450:203-218(2007).
CC   -!- FUNCTION: Component of the eukaryotic translation initiation factor 3
CC       (eIF-3) complex, which is involved in protein synthesis of a
CC       specialized repertoire of mRNAs and, together with other initiation
CC       factors, stimulates binding of mRNA and methionyl-tRNAi to the 40S
CC       ribosome. The eIF-3 complex specifically targets and initiates
CC       translation of a subset of mRNAs involved in cell proliferation.
CC       {ECO:0000255|HAMAP-Rule:MF_03005}.
CC   -!- SUBUNIT: Component of the eukaryotic translation initiation factor 3
CC       (eIF-3) complex. The eIF-3 complex interacts with pix.
CC       {ECO:0000255|HAMAP-Rule:MF_03005}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000255|HAMAP-Rule:MF_03005}.
CC   -!- SIMILARITY: Belongs to the eIF-3 subunit F family. {ECO:0000255|HAMAP-
CC       Rule:MF_03005}.
CC   -!- SEQUENCE CAUTION:
CC       Sequence=EDW89792.1; Type=Erroneous initiation; Evidence={ECO:0000305};
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DR   EMBL; CM000157; EDW89792.1; ALT_INIT; Genomic_DNA.
DR   RefSeq; XP_002090080.1; XM_002090044.2.
DR   AlphaFoldDB; B4NYU1; -.
DR   SMR; B4NYU1; -.
DR   STRING; 7245.FBpp0265757; -.
DR   EnsemblMetazoa; FBtr0401666; FBpp0360568; FBgn0238048.
DR   GeneID; 6529049; -.
DR   eggNOG; KOG2975; Eukaryota.
DR   OrthoDB; 1038775at2759; -.
DR   Proteomes; UP000002282; Chromosome 2L.
DR   GO; GO:0016282; C:eukaryotic 43S preinitiation complex; IEA:UniProtKB-UniRule.
DR   GO; GO:0033290; C:eukaryotic 48S preinitiation complex; IEA:UniProtKB-UniRule.
DR   GO; GO:0005852; C:eukaryotic translation initiation factor 3 complex; IEA:UniProtKB-UniRule.
DR   GO; GO:0070122; F:isopeptidase activity; IEA:InterPro.
DR   GO; GO:0140492; F:metal-dependent deubiquitinase activity; IEA:InterPro.
DR   GO; GO:0003743; F:translation initiation factor activity; IEA:UniProtKB-UniRule.
DR   GO; GO:0031369; F:translation initiation factor binding; IEA:InterPro.
DR   GO; GO:0001732; P:formation of cytoplasmic translation initiation complex; IEA:UniProtKB-UniRule.
DR   CDD; cd08064; MPN_eIF3f; 1.
DR   HAMAP; MF_03005; eIF3f; 1.
DR   InterPro; IPR027531; eIF3f.
DR   InterPro; IPR000555; JAMM/MPN+_dom.
DR   InterPro; IPR037518; MPN.
DR   InterPro; IPR024969; Rpn11/EIF3F_C.
DR   PANTHER; PTHR10540:SF6; PTHR10540:SF6; 1.
DR   Pfam; PF01398; JAB; 1.
DR   Pfam; PF13012; MitMem_reg; 1.
DR   SMART; SM00232; JAB_MPN; 1.
DR   PROSITE; PS50249; MPN; 1.
PE   3: Inferred from homology;
KW   Cytoplasm; Initiation factor; Protein biosynthesis.
FT   CHAIN           1..285
FT                   /note="Eukaryotic translation initiation factor 3 subunit
FT                   F-2"
FT                   /id="PRO_0000364320"
FT   DOMAIN          11..145
FT                   /note="MPN"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU01182"
SQ   SEQUENCE   285 AA;  32475 MW;  8EBD5680B60F7362 CRC64;
     MSRNFSMQAK VFIKPLVLFQ IIDAYERRPK GDNQVMGTLL GRNKEGHFEI TNCFPVPHKE
     HPEINRIDLD ISYASEFLEL NMLTYSNERV LGWFSTGKSV SRSASLLHDY YARECGEIQP
     VHLVMDATLK SQRLSTRLYC AVEIGVPGGT KGLMFSLVPL EISNGNSDLV ALRSLEKQSL
     QQGTKQMERF LPELVQVVDA TRDIQQRLDL VLRYINDVLA RKRKPDNVIG RALYAALTAV
     PLLDSEKFRL MFNTNLRDML MAITLSTMIK TQLEISEKLS CMQDQ