ID   AFSR_STRGR              Reviewed;         974 AA.
AC   Q9S0Y6;
DT   10-FEB-2009, integrated into UniProtKB/Swiss-Prot.
DT   01-MAY-2000, sequence version 1.
DT   25-MAY-2022, entry version 106.
DE   RecName: Full=Regulatory protein AfsR;
GN   Name=afsR;
OS   Streptomyces griseus.
OC   Bacteria; Actinobacteria; Streptomycetales; Streptomycetaceae;
OC   Streptomyces.
OX   NCBI_TaxID=1911;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA], FUNCTION, AND PHOSPHORYLATION.
RX   PubMed=10517581; DOI=10.1099/00221287-145-9-2281;
RA   Umeyama T., Lee P.-C., Ueda K., Horinouchi S.;
RT   "An AfsK/AfsR system involved in the response of aerial mycelium formation
RT   to glucose in Streptomyces griseus.";
RL   Microbiology 145:2281-2292(1999).
CC   -!- FUNCTION: Component of the AfsK/AfsR system involved in the response of
CC       aerial mycelium formation to glucose. {ECO:0000269|PubMed:10517581}.
CC   -!- PTM: Phosphorylated on serines and threonines by AfsK.
CC       {ECO:0000269|PubMed:10517581}.
CC   -!- SIMILARITY: Belongs to the AfsR/DnrI/RedD regulatory family.
CC       {ECO:0000305}.
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DR   EMBL; AB025225; BAA83790.1; -; Genomic_DNA.
DR   AlphaFoldDB; Q9S0Y6; -.
DR   SMR; Q9S0Y6; -.
DR   PRIDE; Q9S0Y6; -.
DR   GO; GO:0043531; F:ADP binding; IEA:InterPro.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR   GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR   GO; GO:0031409; F:pigment binding; IEA:UniProtKB-KW.
DR   GO; GO:0017000; P:antibiotic biosynthetic process; IEA:UniProtKB-KW.
DR   GO; GO:0000160; P:phosphorelay signal transduction system; IEA:UniProtKB-KW.
DR   GO; GO:0006355; P:regulation of transcription, DNA-templated; IEA:InterPro.
DR   CDD; cd15831; BTAD; 1.
DR   Gene3D; 1.10.10.10; -; 1.
DR   Gene3D; 1.25.40.10; -; 3.
DR   Gene3D; 3.40.50.300; -; 1.
DR   InterPro; IPR005158; BTAD.
DR   InterPro; IPR002182; NB-ARC.
DR   InterPro; IPR001867; OmpR/PhoB-type_DNA-bd.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   InterPro; IPR016032; Sig_transdc_resp-reg_C-effctor.
DR   InterPro; IPR011990; TPR-like_helical_dom_sf.
DR   InterPro; IPR019734; TPR_repeat.
DR   InterPro; IPR036388; WH-like_DNA-bd_sf.
DR   Pfam; PF03704; BTAD; 1.
DR   Pfam; PF00931; NB-ARC; 1.
DR   Pfam; PF00486; Trans_reg_C; 1.
DR   SMART; SM01043; BTAD; 1.
DR   SMART; SM00028; TPR; 3.
DR   SMART; SM00862; Trans_reg_C; 1.
DR   SUPFAM; SSF46894; SSF46894; 1.
DR   SUPFAM; SSF48452; SSF48452; 3.
DR   SUPFAM; SSF52540; SSF52540; 1.
DR   PROSITE; PS51755; OMPR_PHOB; 1.
PE   1: Evidence at protein level;
KW   Activator; Antibiotic biosynthesis; ATP-binding; DNA-binding;
KW   Nucleotide-binding; Phosphoprotein; Pigment; Repeat; TPR repeat;
KW   Transcription; Transcription regulation; Two-component regulatory system.
FT   CHAIN           1..974
FT                   /note="Regulatory protein AfsR"
FT                   /id="PRO_0000362162"
FT   DOMAIN          274..591
FT                   /note="NB-ARC"
FT   REPEAT          814..847
FT                   /note="TPR 1"
FT   REPEAT          923..956
FT                   /note="TPR 2"
FT   DNA_BIND        17..114
FT                   /note="OmpR/PhoB-type"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU01091"
SQ   SEQUENCE   974 AA;  104431 MW;  7BAE27CE016709D8 CRC64;
     MDRDNGPRVR VPEQRTPSIP ATADALRFTV LGPVRAWRGS ELLSSGSPQQ RALLTALLLR
     EGRTATAGEL IDAFWGEDPP SQALATIRTY ASRLRKILGQ DTLVSESGGY AIRTERSALD
     LTLAQDLAAE AEKARAAGDR CQARTLINKV LGLWDGEALA SVPGPYADNQ RTRLEEWRLQ
     LTETRLDLDL EVGCHAEAVS ELTALTAAHP LRERLRELLM VALYRSGRQA EALAVYADTR
     RLLAEELGVD PRPELAELQQ RILRADEELA RPADEPAPAP APLKPAQLPA TVPDFTGRSA
     FVTELGSRLA TAEGSVMAVS AVAGIGGVGK TTLAVHVAHQ ARRHFPDGQL YVDLQGAGAR
     AAEPETVLGS FLRALGTADS AIPDTLDERA ALYRSTLDGR RILILLDNAH DAAQIRPLLP
     GTPGCAALVT SRVRMVDLAG AHLVDLDVMS PEEALQLFTR IVGAERVGAE REAALDVVAA
     CGFLPLAIRI AASRLAARRT WTVSVLAAKL ADERRRLDEL QAGDLTVKAT FELGYGQLEP
     AQAHAFRLLG LADGPDISLA AAAALLDLDP HVAEDLLEAL VDTSLVESAA PGRYRYHDLV
     RLYARACAER DEQPPVRREL ALSRLLDFYL ATAAGVYALE RPGERVLDHF TPTEYPGLTF
     PAREAALDWL FTESSGLLAC ARQSAAIGMP QRAADLLMAV VDLGESGANS HQFATAAKAV
     SEAAKAAGVP RAEARARTML SHVHSVSGRF AEAEAEAMRA LDLGRLAQDA VSQGQAPNQR
     GIIALYENRH DDAEAHLTQA LTAFRADGNK PGEAAALCNL SRVHLATGRT ATAVRLAEEG
     VAIYDSDASG LALIGSGRTD PARHVLLEAL QIFRESRQQL WHGMTLFRLS ELHLTEQEGA
     QAAAHAEQSL VVLRGIGGDW RRANVLTVLG RALTVIGQTD RAQVCWGEAL TVFEELGSPE
     AEAVRQLLDP AGVG