EI3G1_DROPS
ID EI3G1_DROPS Reviewed; 269 AA.
AC Q29GU0;
DT 03-MAR-2009, integrated into UniProtKB/Swiss-Prot.
DT 04-APR-2006, sequence version 1.
DT 03-AUG-2022, entry version 88.
DE RecName: Full=Eukaryotic translation initiation factor 3 subunit G-1 {ECO:0000250|UniProtKB:Q9W4X7};
DE AltName: Full=Eukaryotic translation initiation factor 3 RNA-binding subunit 1 {ECO:0000255|HAMAP-Rule:MF_03006};
DE Short=eIF-3 RNA-binding subunit 1 {ECO:0000255|HAMAP-Rule:MF_03006};
DE AltName: Full=Eukaryotic translation initiation factor 3 subunit 4-1 {ECO:0000255|HAMAP-Rule:MF_03006};
GN Name=eIF3g1 {ECO:0000250|UniProtKB:Q9W4X7};
GN Synonyms=eIF3-S4 {ECO:0000255|HAMAP-Rule:MF_03006},
GN eIF3ga {ECO:0000250|UniProtKB:Q9W4X7}; ORFNames=GA21226;
OS Drosophila pseudoobscura pseudoobscura (Fruit fly).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea;
OC Drosophilidae; Drosophila; Sophophora.
OX NCBI_TaxID=46245;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=MV2-25 / Tucson 14011-0121.94;
RX PubMed=15632085; DOI=10.1101/gr.3059305;
RA Richards S., Liu Y., Bettencourt B.R., Hradecky P., Letovsky S.,
RA Nielsen R., Thornton K., Hubisz M.J., Chen R., Meisel R.P., Couronne O.,
RA Hua S., Smith M.A., Zhang P., Liu J., Bussemaker H.J., van Batenburg M.F.,
RA Howells S.L., Scherer S.E., Sodergren E., Matthews B.B., Crosby M.A.,
RA Schroeder A.J., Ortiz-Barrientos D., Rives C.M., Metzker M.L., Muzny D.M.,
RA Scott G., Steffen D., Wheeler D.A., Worley K.C., Havlak P., Durbin K.J.,
RA Egan A., Gill R., Hume J., Morgan M.B., Miner G., Hamilton C., Huang Y.,
RA Waldron L., Verduzco D., Clerc-Blankenburg K.P., Dubchak I., Noor M.A.F.,
RA Anderson W., White K.P., Clark A.G., Schaeffer S.W., Gelbart W.M.,
RA Weinstock G.M., Gibbs R.A.;
RT "Comparative genome sequencing of Drosophila pseudoobscura: chromosomal,
RT gene, and cis-element evolution.";
RL Genome Res. 15:1-18(2005).
CC -!- FUNCTION: RNA-binding component of the eukaryotic translation
CC initiation factor 3 (eIF-3) complex, which is involved in protein
CC synthesis of a specialized repertoire of mRNAs and, together with other
CC initiation factors, stimulates binding of mRNA and methionyl-tRNAi to
CC the 40S ribosome. The eIF-3 complex specifically targets and initiates
CC translation of a subset of mRNAs involved in cell proliferation. This
CC subunit can bind 18S rRNA. {ECO:0000255|HAMAP-Rule:MF_03006}.
CC -!- SUBUNIT: Component of the eukaryotic translation initiation factor 3
CC (eIF-3) complex. The eIF-3 complex interacts with pix.
CC {ECO:0000255|HAMAP-Rule:MF_03006}.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000255|HAMAP-Rule:MF_03006}.
CC -!- SIMILARITY: Belongs to the eIF-3 subunit G family. {ECO:0000255|HAMAP-
CC Rule:MF_03006}.
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DR EMBL; CH379064; EAL32019.1; -; Genomic_DNA.
DR RefSeq; XP_001354963.1; XM_001354927.3.
DR AlphaFoldDB; Q29GU0; -.
DR STRING; 7237.FBpp0273221; -.
DR EnsemblMetazoa; FBtr0274783; FBpp0273221; FBgn0081214.
DR GeneID; 4815012; -.
DR KEGG; dpo:Dpse_GA21226; -.
DR eggNOG; KOG0122; Eukaryota.
DR HOGENOM; CLU_034595_0_0_1; -.
DR InParanoid; Q29GU0; -.
DR OMA; TTKCPFK; -.
DR PhylomeDB; Q29GU0; -.
DR Proteomes; UP000001819; Chromosome X.
DR Bgee; FBgn0081214; Expressed in female reproductive system and 2 other tissues.
DR GO; GO:0016282; C:eukaryotic 43S preinitiation complex; IEA:UniProtKB-UniRule.
DR GO; GO:0033290; C:eukaryotic 48S preinitiation complex; IEA:UniProtKB-UniRule.
DR GO; GO:0005852; C:eukaryotic translation initiation factor 3 complex; IEA:UniProtKB-UniRule.
DR GO; GO:0003723; F:RNA binding; IEA:UniProtKB-UniRule.
DR GO; GO:0003743; F:translation initiation factor activity; IEA:UniProtKB-UniRule.
DR GO; GO:0001732; P:formation of cytoplasmic translation initiation complex; IEA:UniProtKB-UniRule.
DR CDD; cd12933; eIF3G; 1.
DR CDD; cd12408; RRM_eIF3G_like; 1.
DR Gene3D; 3.30.70.330; -; 1.
DR HAMAP; MF_03006; eIF3g; 1.
DR InterPro; IPR017334; eIF3_g.
DR InterPro; IPR024675; eIF3g_N.
DR InterPro; IPR034240; eIF3G_RRM.
DR InterPro; IPR012677; Nucleotide-bd_a/b_plait_sf.
DR InterPro; IPR035979; RBD_domain_sf.
DR InterPro; IPR000504; RRM_dom.
DR Pfam; PF12353; eIF3g; 1.
DR Pfam; PF00076; RRM_1; 1.
DR PIRSF; PIRSF037949; Transl_init_eIF-3_RNA-bind; 1.
DR SMART; SM00360; RRM; 1.
DR SUPFAM; SSF54928; SSF54928; 1.
DR PROSITE; PS50102; RRM; 1.
PE 3: Inferred from homology;
KW Cytoplasm; Initiation factor; Protein biosynthesis; Reference proteome;
KW RNA-binding.
FT CHAIN 1..269
FT /note="Eukaryotic translation initiation factor 3 subunit
FT G-1"
FT /id="PRO_0000365419"
FT DOMAIN 188..266
FT /note="RRM"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_03006"
SQ SEQUENCE 269 AA; 29932 MW; C9AD08D012758CF5 CRC64;
MPGVETIKSS WADEVELDYG GLPPTTENVE NGHKYVTEYK YNKDDKKTKV VRTYKISKQV
VPKTVAKRRT WTKFGESKSD KPGPNSHTTM VSEEIIMQFL NSKEDEKAND PLLDPTKNIA
KCRICNGEHW SVNCPYKGTA MDTNLMEKKA AAAASAAVDA PKSGKYVPPF LKDSQKGGLG
MRGRDDTAAI RISNLSESMT EADLEELVKK IGPQSKMYLA RDKNTGLCKG FAYVHFKQRK
DAAAAIEILN GHGYDHLILS VEWSKPQNN
