ID   EI3G1_DROSI             Reviewed;         269 AA.
AC   B4NTY9;
DT   03-MAR-2009, integrated into UniProtKB/Swiss-Prot.
DT   23-SEP-2008, sequence version 1.
DT   03-AUG-2022, entry version 72.
DE   RecName: Full=Eukaryotic translation initiation factor 3 subunit G-1 {ECO:0000250|UniProtKB:Q9W4X7};
DE   AltName: Full=Eukaryotic translation initiation factor 3 RNA-binding subunit 1 {ECO:0000255|HAMAP-Rule:MF_03006};
DE            Short=eIF-3 RNA-binding subunit 1 {ECO:0000255|HAMAP-Rule:MF_03006};
DE   AltName: Full=Eukaryotic translation initiation factor 3 subunit 4-1 {ECO:0000255|HAMAP-Rule:MF_03006};
GN   Name=eIF3g1 {ECO:0000250|UniProtKB:Q9W4X7};
GN   Synonyms=eIF3-S4 {ECO:0000255|HAMAP-Rule:MF_03006},
GN   eIF3ga {ECO:0000250|UniProtKB:Q9W4X7}; ORFNames=GD24609;
OS   Drosophila simulans (Fruit fly).
OC   Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC   Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea;
OC   Drosophilidae; Drosophila; Sophophora.
OX   NCBI_TaxID=7240;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=17994087; DOI=10.1038/nature06341;
RG   Drosophila 12 genomes consortium;
RT   "Evolution of genes and genomes on the Drosophila phylogeny.";
RL   Nature 450:203-218(2007).
CC   -!- FUNCTION: RNA-binding component of the eukaryotic translation
CC       initiation factor 3 (eIF-3) complex, which is involved in protein
CC       synthesis of a specialized repertoire of mRNAs and, together with other
CC       initiation factors, stimulates binding of mRNA and methionyl-tRNAi to
CC       the 40S ribosome. The eIF-3 complex specifically targets and initiates
CC       translation of a subset of mRNAs involved in cell proliferation. This
CC       subunit can bind 18S rRNA. {ECO:0000255|HAMAP-Rule:MF_03006}.
CC   -!- SUBUNIT: Component of the eukaryotic translation initiation factor 3
CC       (eIF-3) complex. The eIF-3 complex interacts with pix.
CC       {ECO:0000255|HAMAP-Rule:MF_03006}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000255|HAMAP-Rule:MF_03006}.
CC   -!- SIMILARITY: Belongs to the eIF-3 subunit G family. {ECO:0000255|HAMAP-
CC       Rule:MF_03006}.
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DR   EMBL; CH983411; EDX16436.1; -; Genomic_DNA.
DR   RefSeq; XP_016037887.1; XM_016180883.1.
DR   AlphaFoldDB; B4NTY9; -.
DR   SMR; B4NTY9; -.
DR   STRING; 7240.B4NTY9; -.
DR   EnsemblMetazoa; FBtr0224519; FBpp0223011; FBgn0195937.
DR   GeneID; 6739959; -.
DR   HOGENOM; CLU_034595_0_0_1; -.
DR   OMA; TTKCPFK; -.
DR   PhylomeDB; B4NTY9; -.
DR   Proteomes; UP000000304; Unassembled WGS sequence.
DR   Bgee; FBgn0195937; Expressed in embryo and 3 other tissues.
DR   GO; GO:0016282; C:eukaryotic 43S preinitiation complex; IEA:UniProtKB-UniRule.
DR   GO; GO:0033290; C:eukaryotic 48S preinitiation complex; IEA:UniProtKB-UniRule.
DR   GO; GO:0005852; C:eukaryotic translation initiation factor 3 complex; IEA:UniProtKB-UniRule.
DR   GO; GO:0003723; F:RNA binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0003743; F:translation initiation factor activity; IEA:UniProtKB-UniRule.
DR   GO; GO:0001732; P:formation of cytoplasmic translation initiation complex; IEA:UniProtKB-UniRule.
DR   CDD; cd12933; eIF3G; 1.
DR   CDD; cd12408; RRM_eIF3G_like; 1.
DR   Gene3D; 3.30.70.330; -; 1.
DR   HAMAP; MF_03006; eIF3g; 1.
DR   InterPro; IPR017334; eIF3_g.
DR   InterPro; IPR024675; eIF3g_N.
DR   InterPro; IPR034240; eIF3G_RRM.
DR   InterPro; IPR012677; Nucleotide-bd_a/b_plait_sf.
DR   InterPro; IPR035979; RBD_domain_sf.
DR   InterPro; IPR000504; RRM_dom.
DR   Pfam; PF12353; eIF3g; 1.
DR   Pfam; PF00076; RRM_1; 1.
DR   PIRSF; PIRSF037949; Transl_init_eIF-3_RNA-bind; 1.
DR   SMART; SM00360; RRM; 1.
DR   SUPFAM; SSF54928; SSF54928; 1.
DR   PROSITE; PS50102; RRM; 1.
PE   3: Inferred from homology;
KW   Cytoplasm; Initiation factor; Protein biosynthesis; Reference proteome;
KW   RNA-binding.
FT   CHAIN           1..269
FT                   /note="Eukaryotic translation initiation factor 3 subunit
FT                   G-1"
FT                   /id="PRO_0000365423"
FT   DOMAIN          188..266
FT                   /note="RRM"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_03006"
SQ   SEQUENCE   269 AA;  29994 MW;  920022D2D0D1712D CRC64;
     MPGVETIKSS WADEVELDYG GLPPTTETVE NGQKYVTEYK YNKDDKKTKV VRTYKISKQV
     VPKTVAKRRT WTKFGESKND KPGPNSQTTM VSEEIFMQFL NSKEDEKAND PLLDPTKNIA
     KCRICNGEHW SVNCPYKGTA MDTNMMEKKA SAAAAAAVDA PKSGKYVPPF LKDSQKGALG
     MRGRDDTAAI RISNLSESMT EADLEELVKK IGPQSKMYLA RDKNTGLCKG FAYVHFKQRK
     DAAAAIEILN GHGYDHLILS VEWSKPQNN