EI3G2_DROPS
ID EI3G2_DROPS Reviewed; 274 AA.
AC Q298C0;
DT 03-MAR-2009, integrated into UniProtKB/Swiss-Prot.
DT 04-APR-2006, sequence version 1.
DT 03-AUG-2022, entry version 82.
DE RecName: Full=Eukaryotic translation initiation factor 3 subunit G-2 {ECO:0000250|UniProtKB:Q9VDM6};
DE AltName: Full=Eukaryotic translation initiation factor 3 RNA-binding subunit 2 {ECO:0000255|HAMAP-Rule:MF_03006};
DE Short=eIF-3 RNA-binding subunit 2 {ECO:0000255|HAMAP-Rule:MF_03006};
DE AltName: Full=Eukaryotic translation initiation factor 3 subunit 4-2 {ECO:0000255|HAMAP-Rule:MF_03006};
GN Name=eIF3g2 {ECO:0000250|UniProtKB:Q9VDM6};
GN Synonyms=eIF3-S4 {ECO:0000255|HAMAP-Rule:MF_03006},
GN eIF3gb {ECO:0000250|UniProtKB:Q9VDM6}; ORFNames=GA10616;
OS Drosophila pseudoobscura pseudoobscura (Fruit fly).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea;
OC Drosophilidae; Drosophila; Sophophora.
OX NCBI_TaxID=46245;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=MV2-25 / Tucson 14011-0121.94;
RX PubMed=15632085; DOI=10.1101/gr.3059305;
RA Richards S., Liu Y., Bettencourt B.R., Hradecky P., Letovsky S.,
RA Nielsen R., Thornton K., Hubisz M.J., Chen R., Meisel R.P., Couronne O.,
RA Hua S., Smith M.A., Zhang P., Liu J., Bussemaker H.J., van Batenburg M.F.,
RA Howells S.L., Scherer S.E., Sodergren E., Matthews B.B., Crosby M.A.,
RA Schroeder A.J., Ortiz-Barrientos D., Rives C.M., Metzker M.L., Muzny D.M.,
RA Scott G., Steffen D., Wheeler D.A., Worley K.C., Havlak P., Durbin K.J.,
RA Egan A., Gill R., Hume J., Morgan M.B., Miner G., Hamilton C., Huang Y.,
RA Waldron L., Verduzco D., Clerc-Blankenburg K.P., Dubchak I., Noor M.A.F.,
RA Anderson W., White K.P., Clark A.G., Schaeffer S.W., Gelbart W.M.,
RA Weinstock G.M., Gibbs R.A.;
RT "Comparative genome sequencing of Drosophila pseudoobscura: chromosomal,
RT gene, and cis-element evolution.";
RL Genome Res. 15:1-18(2005).
CC -!- FUNCTION: RNA-binding component of the eukaryotic translation
CC initiation factor 3 (eIF-3) complex, which is involved in protein
CC synthesis of a specialized repertoire of mRNAs and, together with other
CC initiation factors, stimulates binding of mRNA and methionyl-tRNAi to
CC the 40S ribosome. The eIF-3 complex specifically targets and initiates
CC translation of a subset of mRNAs involved in cell proliferation. This
CC subunit can bind 18S rRNA. {ECO:0000255|HAMAP-Rule:MF_03006}.
CC -!- SUBUNIT: Component of the eukaryotic translation initiation factor 3
CC (eIF-3) complex. The eIF-3 complex interacts with pix.
CC {ECO:0000255|HAMAP-Rule:MF_03006}.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000255|HAMAP-Rule:MF_03006}.
CC -!- SIMILARITY: Belongs to the eIF-3 subunit G family. {ECO:0000255|HAMAP-
CC Rule:MF_03006}.
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DR EMBL; CM000070; EAL28035.1; -; Genomic_DNA.
DR RefSeq; XP_001358892.1; XM_001358855.3.
DR RefSeq; XP_015037438.1; XM_015181952.1.
DR AlphaFoldDB; Q298C0; -.
DR SMR; Q298C0; -.
DR STRING; 7237.FBpp0284069; -.
DR EnsemblMetazoa; FBtr0285631; FBpp0284069; FBgn0070673.
DR EnsemblMetazoa; FBtr0369308; FBpp0331909; FBgn0070673.
DR GeneID; 4801862; -.
DR KEGG; dpo:Dpse_GA10616; -.
DR eggNOG; KOG0122; Eukaryota.
DR HOGENOM; CLU_034595_0_0_1; -.
DR InParanoid; Q298C0; -.
DR OMA; MQFIGSK; -.
DR PhylomeDB; Q298C0; -.
DR Proteomes; UP000001819; Chromosome 2.
DR Bgee; FBgn0070673; Expressed in male reproductive system and 1 other tissue.
DR GO; GO:0016282; C:eukaryotic 43S preinitiation complex; IEA:UniProtKB-UniRule.
DR GO; GO:0033290; C:eukaryotic 48S preinitiation complex; IEA:UniProtKB-UniRule.
DR GO; GO:0005852; C:eukaryotic translation initiation factor 3 complex; IEA:UniProtKB-UniRule.
DR GO; GO:0003723; F:RNA binding; IEA:UniProtKB-UniRule.
DR GO; GO:0003743; F:translation initiation factor activity; IEA:UniProtKB-UniRule.
DR GO; GO:0001732; P:formation of cytoplasmic translation initiation complex; IEA:UniProtKB-UniRule.
DR CDD; cd12933; eIF3G; 1.
DR CDD; cd12408; RRM_eIF3G_like; 1.
DR Gene3D; 3.30.70.330; -; 1.
DR HAMAP; MF_03006; eIF3g; 1.
DR InterPro; IPR017334; eIF3_g.
DR InterPro; IPR024675; eIF3g_N.
DR InterPro; IPR034240; eIF3G_RRM.
DR InterPro; IPR012677; Nucleotide-bd_a/b_plait_sf.
DR InterPro; IPR035979; RBD_domain_sf.
DR InterPro; IPR000504; RRM_dom.
DR Pfam; PF12353; eIF3g; 1.
DR Pfam; PF00076; RRM_1; 1.
DR PIRSF; PIRSF037949; Transl_init_eIF-3_RNA-bind; 1.
DR SMART; SM00360; RRM; 1.
DR SUPFAM; SSF54928; SSF54928; 1.
DR PROSITE; PS50102; RRM; 1.
PE 3: Inferred from homology;
KW Cytoplasm; Initiation factor; Protein biosynthesis; Reference proteome;
KW RNA-binding.
FT CHAIN 1..274
FT /note="Eukaryotic translation initiation factor 3 subunit
FT G-2"
FT /id="PRO_0000365420"
FT DOMAIN 194..272
FT /note="RRM"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_03006"
SQ SEQUENCE 274 AA; 30468 MW; 3F0E5E035D1F2ED4 CRC64;
MKPMKTSWAD EVEADYVDGL PPTKEYTQGN LKFVAEYKYN EDGKKVKVVR TYKIQKQTVP
KVVARRRNWS KFGDSRLDKP GPCSQTTMVA EEVHMVFISS KELEQAQAQE PQMEPGKNIA
RCRICNGEHW SVNCPYKGTS MDSKTLMESK ATAAAAAAVS DASKTGKYVS PFLKEGGCAI
GGGIGAKPWV RERSAVRISN LSESMTEADL EELVKKIGPH TKLYLAREKN TGLCKGFAYV
HFKFRQDAAA AIEILNGHGY DHLILCVEWS KPQP
