ID   EI3G2_DROSI             Reviewed;         273 AA.
AC   B4QS37;
DT   03-MAR-2009, integrated into UniProtKB/Swiss-Prot.
DT   23-SEP-2008, sequence version 1.
DT   03-AUG-2022, entry version 71.
DE   RecName: Full=Eukaryotic translation initiation factor 3 subunit G-2 {ECO:0000250|UniProtKB:Q9VDM6};
DE   AltName: Full=Eukaryotic translation initiation factor 3 RNA-binding subunit 2 {ECO:0000255|HAMAP-Rule:MF_03006};
DE            Short=eIF-3 RNA-binding subunit 2 {ECO:0000255|HAMAP-Rule:MF_03006};
DE   AltName: Full=Eukaryotic translation initiation factor 3 subunit 4-2 {ECO:0000255|HAMAP-Rule:MF_03006};
GN   Name=eIF3g2 {ECO:0000250|UniProtKB:Q9VDM6};
GN   Synonyms=eIF3-S4 {ECO:0000255|HAMAP-Rule:MF_03006},
GN   eIF3gb {ECO:0000250|UniProtKB:Q9VDM6}; ORFNames=GD19352;
OS   Drosophila simulans (Fruit fly).
OC   Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC   Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea;
OC   Drosophilidae; Drosophila; Sophophora.
OX   NCBI_TaxID=7240;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=17994087; DOI=10.1038/nature06341;
RG   Drosophila 12 genomes consortium;
RT   "Evolution of genes and genomes on the Drosophila phylogeny.";
RL   Nature 450:203-218(2007).
CC   -!- FUNCTION: RNA-binding component of the eukaryotic translation
CC       initiation factor 3 (eIF-3) complex, which is involved in protein
CC       synthesis of a specialized repertoire of mRNAs and, together with other
CC       initiation factors, stimulates binding of mRNA and methionyl-tRNAi to
CC       the 40S ribosome. The eIF-3 complex specifically targets and initiates
CC       translation of a subset of mRNAs involved in cell proliferation. This
CC       subunit can bind 18S rRNA. {ECO:0000255|HAMAP-Rule:MF_03006}.
CC   -!- SUBUNIT: Component of the eukaryotic translation initiation factor 3
CC       (eIF-3) complex. The eIF-3 complex interacts with pix.
CC       {ECO:0000255|HAMAP-Rule:MF_03006}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000255|HAMAP-Rule:MF_03006}.
CC   -!- SIMILARITY: Belongs to the eIF-3 subunit G family. {ECO:0000255|HAMAP-
CC       Rule:MF_03006}.
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DR   EMBL; CM000364; EDX12233.1; -; Genomic_DNA.
DR   RefSeq; XP_002102730.1; XM_002102694.2.
DR   AlphaFoldDB; B4QS37; -.
DR   SMR; B4QS37; -.
DR   STRING; 7240.B4QS37; -.
DR   EnsemblMetazoa; FBtr0219262; FBpp0217754; FBgn0190854.
DR   GeneID; 6727345; -.
DR   HOGENOM; CLU_034595_0_0_1; -.
DR   OMA; MQFIGSK; -.
DR   PhylomeDB; B4QS37; -.
DR   Proteomes; UP000000304; Chromosome 3r.
DR   Bgee; FBgn0190854; Expressed in male reproductive system and 2 other tissues.
DR   GO; GO:0016282; C:eukaryotic 43S preinitiation complex; IEA:UniProtKB-UniRule.
DR   GO; GO:0033290; C:eukaryotic 48S preinitiation complex; IEA:UniProtKB-UniRule.
DR   GO; GO:0005852; C:eukaryotic translation initiation factor 3 complex; IEA:UniProtKB-UniRule.
DR   GO; GO:0003723; F:RNA binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0003743; F:translation initiation factor activity; IEA:UniProtKB-UniRule.
DR   GO; GO:0001732; P:formation of cytoplasmic translation initiation complex; IEA:UniProtKB-UniRule.
DR   CDD; cd12933; eIF3G; 1.
DR   CDD; cd12408; RRM_eIF3G_like; 1.
DR   Gene3D; 3.30.70.330; -; 1.
DR   HAMAP; MF_03006; eIF3g; 1.
DR   InterPro; IPR017334; eIF3_g.
DR   InterPro; IPR024675; eIF3g_N.
DR   InterPro; IPR034240; eIF3G_RRM.
DR   InterPro; IPR012677; Nucleotide-bd_a/b_plait_sf.
DR   InterPro; IPR035979; RBD_domain_sf.
DR   InterPro; IPR000504; RRM_dom.
DR   Pfam; PF12353; eIF3g; 1.
DR   Pfam; PF00076; RRM_1; 1.
DR   PIRSF; PIRSF037949; Transl_init_eIF-3_RNA-bind; 1.
DR   SMART; SM00360; RRM; 1.
DR   SUPFAM; SSF54928; SSF54928; 1.
DR   PROSITE; PS50102; RRM; 1.
PE   3: Inferred from homology;
KW   Cytoplasm; Initiation factor; Protein biosynthesis; Reference proteome;
KW   RNA-binding.
FT   CHAIN           1..273
FT                   /note="Eukaryotic translation initiation factor 3 subunit
FT                   G-2"
FT                   /id="PRO_0000365424"
FT   DOMAIN          193..271
FT                   /note="RRM"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_03006"
SQ   SEQUENCE   273 AA;  30555 MW;  E333E94D767AF215 CRC64;
     MKSFITSWAD EVDADYVDGL PPSNEYIKGD YKYVTEYKFN DDGKKVKVVR TFKIEKQIVP
     KAVARRRNWV KFGDSRSDKP GPNSQTTMAS EEILMQFIGS KEFDQTHETQ LDPGKNIAKC
     RICNGEHWSV NCPYKGTSMD SKTMMETKAN AAAAAAISDP SKTGKYVPPF MKDGGGISGS
     KNWGRGRDRD DSSAVRISNL SESMTETDLE ELVKKIGPHT KMYLAREKNS GLCKGFAYVH
     FKFRQDAAAA IEVLNGHGYD HLILCVEWSK PQP