EI3G2_DROYA
ID EI3G2_DROYA Reviewed; 273 AA.
AC B4PP90;
DT 03-MAR-2009, integrated into UniProtKB/Swiss-Prot.
DT 23-SEP-2008, sequence version 1.
DT 03-AUG-2022, entry version 72.
DE RecName: Full=Eukaryotic translation initiation factor 3 subunit G-2 {ECO:0000250|UniProtKB:Q9VDM6};
DE AltName: Full=Eukaryotic translation initiation factor 3 RNA-binding subunit 2 {ECO:0000255|HAMAP-Rule:MF_03006};
DE Short=eIF-3 RNA-binding subunit-2 {ECO:0000255|HAMAP-Rule:MF_03006};
DE AltName: Full=Eukaryotic translation initiation factor 3 subunit 4-2 {ECO:0000255|HAMAP-Rule:MF_03006};
GN Name=eIF3g2 {ECO:0000250|UniProtKB:Q9VDM6};
GN Synonyms=eIF3-S4 {ECO:0000255|HAMAP-Rule:MF_03006},
GN eIF3gb {ECO:0000250|UniProtKB:Q9VDM6}; ORFNames=GE25664;
OS Drosophila yakuba (Fruit fly).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea;
OC Drosophilidae; Drosophila; Sophophora.
OX NCBI_TaxID=7245;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Tai18E2 / Tucson 14021-0261.01;
RX PubMed=17994087; DOI=10.1038/nature06341;
RG Drosophila 12 genomes consortium;
RT "Evolution of genes and genomes on the Drosophila phylogeny.";
RL Nature 450:203-218(2007).
CC -!- FUNCTION: RNA-binding component of the eukaryotic translation
CC initiation factor 3 (eIF-3) complex, which is involved in protein
CC synthesis of a specialized repertoire of mRNAs and, together with other
CC initiation factors, stimulates binding of mRNA and methionyl-tRNAi to
CC the 40S ribosome. The eIF-3 complex specifically targets and initiates
CC translation of a subset of mRNAs involved in cell proliferation. This
CC subunit can bind 18S rRNA. {ECO:0000255|HAMAP-Rule:MF_03006}.
CC -!- SUBUNIT: Component of the eukaryotic translation initiation factor 3
CC (eIF-3) complex. The eIF-3 complex interacts with pix.
CC {ECO:0000255|HAMAP-Rule:MF_03006}.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000255|HAMAP-Rule:MF_03006}.
CC -!- SIMILARITY: Belongs to the eIF-3 subunit G family. {ECO:0000255|HAMAP-
CC Rule:MF_03006}.
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DR EMBL; CM000160; EDW96129.1; -; Genomic_DNA.
DR RefSeq; XP_002096417.1; XM_002096381.2.
DR AlphaFoldDB; B4PP90; -.
DR SMR; B4PP90; -.
DR STRING; 7245.FBpp0270674; -.
DR EnsemblMetazoa; FBtr0272182; FBpp0270674; FBgn0242726.
DR GeneID; 6535794; -.
DR KEGG; dya:Dyak_GE25664; -.
DR eggNOG; KOG0122; Eukaryota.
DR HOGENOM; CLU_034595_0_0_1; -.
DR OMA; MQFIGSK; -.
DR OrthoDB; 1226059at2759; -.
DR PhylomeDB; B4PP90; -.
DR Proteomes; UP000002282; Chromosome 3R.
DR GO; GO:0016282; C:eukaryotic 43S preinitiation complex; IEA:UniProtKB-UniRule.
DR GO; GO:0033290; C:eukaryotic 48S preinitiation complex; IEA:UniProtKB-UniRule.
DR GO; GO:0005852; C:eukaryotic translation initiation factor 3 complex; IEA:UniProtKB-UniRule.
DR GO; GO:0003723; F:RNA binding; IEA:UniProtKB-UniRule.
DR GO; GO:0003743; F:translation initiation factor activity; IEA:UniProtKB-UniRule.
DR GO; GO:0001732; P:formation of cytoplasmic translation initiation complex; IEA:UniProtKB-UniRule.
DR CDD; cd12933; eIF3G; 1.
DR CDD; cd12408; RRM_eIF3G_like; 1.
DR Gene3D; 3.30.70.330; -; 1.
DR HAMAP; MF_03006; eIF3g; 1.
DR InterPro; IPR017334; eIF3_g.
DR InterPro; IPR024675; eIF3g_N.
DR InterPro; IPR034240; eIF3G_RRM.
DR InterPro; IPR012677; Nucleotide-bd_a/b_plait_sf.
DR InterPro; IPR035979; RBD_domain_sf.
DR InterPro; IPR000504; RRM_dom.
DR Pfam; PF12353; eIF3g; 1.
DR Pfam; PF00076; RRM_1; 1.
DR PIRSF; PIRSF037949; Transl_init_eIF-3_RNA-bind; 1.
DR SMART; SM00360; RRM; 1.
DR SUPFAM; SSF54928; SSF54928; 1.
DR PROSITE; PS50102; RRM; 1.
PE 3: Inferred from homology;
KW Cytoplasm; Initiation factor; Protein biosynthesis; RNA-binding.
FT CHAIN 1..273
FT /note="Eukaryotic translation initiation factor 3 subunit
FT G-2"
FT /id="PRO_0000365430"
FT DOMAIN 193..271
FT /note="RRM"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_03006"
FT REGION 165..193
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 273 AA; 30495 MW; BAAF5DA2CC49B093 CRC64;
MKAFNTSWAD EVDADYVDGL PPSNEYIEGD YKYVTEYKFN DDGKKVKVVR TFKIEKQIVP
KAVARRRSWV KFGDSRLDKP GPNSQTTMAS EEIFMQFIGS KEFDQTHETQ LDPGKNIAKC
RICNGEHWSV NCPYKGTSMD SKTMMETKAN AAAAAAISDP SKTGKYVPPF MKDGGGGPGG
KNWGRGRERD DSSAVRISNL SESMTEADLE ELVKKIGPHT KMYLAREKNT GLCKGFAYVH
FKFRQDAAAA IEVLNGHGYD HLILCVEWSK PQP
