ID   EI3GB_XENLA             Reviewed;         308 AA.
AC   Q641B2;
DT   03-MAR-2009, integrated into UniProtKB/Swiss-Prot.
DT   25-OCT-2004, sequence version 1.
DT   03-AUG-2022, entry version 89.
DE   RecName: Full=Eukaryotic translation initiation factor 3 subunit G-B {ECO:0000255|HAMAP-Rule:MF_03006};
DE            Short=eIF3g-B {ECO:0000255|HAMAP-Rule:MF_03006};
DE   AltName: Full=Eukaryotic translation initiation factor 3 RNA-binding subunit B {ECO:0000255|HAMAP-Rule:MF_03006};
DE            Short=eIF-3 RNA-binding subunit B {ECO:0000255|HAMAP-Rule:MF_03006};
DE   AltName: Full=Eukaryotic translation initiation factor 3 subunit 4-B {ECO:0000255|HAMAP-Rule:MF_03006};
GN   Name=eif3g-b; Synonyms=eif3s4-b;
OS   Xenopus laevis (African clawed frog).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC   Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Xenopus.
OX   NCBI_TaxID=8355;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Embryo;
RG   NIH - Xenopus Gene Collection (XGC) project;
RL   Submitted (SEP-2004) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: RNA-binding component of the eukaryotic translation
CC       initiation factor 3 (eIF-3) complex, which is involved in protein
CC       synthesis of a specialized repertoire of mRNAs and, together with other
CC       initiation factors, stimulates binding of mRNA and methionyl-tRNAi to
CC       the 40S ribosome. The eIF-3 complex specifically targets and initiates
CC       translation of a subset of mRNAs involved in cell proliferation. This
CC       subunit can bind 18S rRNA. {ECO:0000255|HAMAP-Rule:MF_03006}.
CC   -!- SUBUNIT: Component of the eukaryotic translation initiation factor 3
CC       (eIF-3) complex, which is composed of 13 subunits: eif3a, eif3b, eif3c,
CC       eif3d, eif3e, eif3f, eif3g, eif3h, eif3i, eif3j, eif3k, eif3l and
CC       eif3m. {ECO:0000255|HAMAP-Rule:MF_03006}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000255|HAMAP-Rule:MF_03006}.
CC   -!- SIMILARITY: Belongs to the eIF-3 subunit G family. {ECO:0000255|HAMAP-
CC       Rule:MF_03006}.
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DR   EMBL; BC082427; AAH82427.1; -; mRNA.
DR   RefSeq; NP_001087888.1; NM_001094419.1.
DR   AlphaFoldDB; Q641B2; -.
DR   BMRB; Q641B2; -.
DR   SMR; Q641B2; -.
DR   BioGRID; 104609; 1.
DR   PRIDE; Q641B2; -.
DR   DNASU; 447749; -.
DR   GeneID; 447749; -.
DR   KEGG; xla:447749; -.
DR   CTD; 447749; -.
DR   Xenbase; XB-GENE-6070476; eif3g.L.
DR   OMA; TTKCPFK; -.
DR   OrthoDB; 1226059at2759; -.
DR   Proteomes; UP000186698; Chromosome 3L.
DR   Bgee; 447749; Expressed in pancreas and 19 other tissues.
DR   GO; GO:0016282; C:eukaryotic 43S preinitiation complex; IEA:UniProtKB-UniRule.
DR   GO; GO:0033290; C:eukaryotic 48S preinitiation complex; IEA:UniProtKB-UniRule.
DR   GO; GO:0005852; C:eukaryotic translation initiation factor 3 complex; ISS:UniProtKB.
DR   GO; GO:0003723; F:RNA binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0003743; F:translation initiation factor activity; IEA:UniProtKB-UniRule.
DR   GO; GO:0001732; P:formation of cytoplasmic translation initiation complex; IEA:UniProtKB-UniRule.
DR   GO; GO:0006413; P:translational initiation; ISS:UniProtKB.
DR   CDD; cd12933; eIF3G; 1.
DR   CDD; cd12408; RRM_eIF3G_like; 1.
DR   Gene3D; 3.30.70.330; -; 1.
DR   HAMAP; MF_03006; eIF3g; 1.
DR   InterPro; IPR017334; eIF3_g.
DR   InterPro; IPR024675; eIF3g_N.
DR   InterPro; IPR034240; eIF3G_RRM.
DR   InterPro; IPR012677; Nucleotide-bd_a/b_plait_sf.
DR   InterPro; IPR035979; RBD_domain_sf.
DR   InterPro; IPR000504; RRM_dom.
DR   Pfam; PF12353; eIF3g; 1.
DR   Pfam; PF00076; RRM_1; 1.
DR   PIRSF; PIRSF037949; Transl_init_eIF-3_RNA-bind; 1.
DR   SMART; SM00360; RRM; 1.
DR   SUPFAM; SSF54928; SSF54928; 1.
DR   PROSITE; PS50102; RRM; 1.
PE   2: Evidence at transcript level;
KW   Cytoplasm; Initiation factor; Protein biosynthesis; Reference proteome;
KW   RNA-binding.
FT   CHAIN           1..308
FT                   /note="Eukaryotic translation initiation factor 3 subunit
FT                   G-B"
FT                   /id="PRO_0000365399"
FT   DOMAIN          227..305
FT                   /note="RRM"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_03006"
FT   REGION          1..35
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          176..227
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   308 AA;  34460 MW;  952919459181E7F0 CRC64;
     MPTGDYDSKP SWADQVEEEG IDVEPLSPQI KKQDPASFVL DTPREVINGN IKTITEYKLN
     DKDKKIKIVR TFKIETLKAS KVVAHRKNWK KFGNSEYDPP GPNVATTTVS DDVLMTFITN
     KEDLNNQEEE DPMNKLKGQK IVSCRICKGD HWTTRCPYKD TLGPMQKELA EQLGLSTADK
     EKAPGAEPEP AQAPVSKTGK YVPPSLRDGG SRRGESMQPN RRADDNATIR VTNLSEDTRE
     TDLQELFRPF GSISRIYLAK DKTTGQSKGF AFISFHRRED AARAIAGVSG FGYDHLILNV
     EWAKPSTN