EI3HA_DANRE
ID EI3HA_DANRE Reviewed; 335 AA.
AC Q6AXJ2;
DT 03-MAR-2009, integrated into UniProtKB/Swiss-Prot.
DT 13-SEP-2004, sequence version 1.
DT 03-AUG-2022, entry version 116.
DE RecName: Full=Eukaryotic translation initiation factor 3 subunit H-A {ECO:0000255|HAMAP-Rule:MF_03007};
DE Short=eIF3h-A {ECO:0000255|HAMAP-Rule:MF_03007};
DE AltName: Full=Eukaryotic translation initiation factor 3 subunit 3-A {ECO:0000255|HAMAP-Rule:MF_03007};
DE AltName: Full=eIF-3-gamma-A;
DE AltName: Full=eIF3 p40 subunit A {ECO:0000255|HAMAP-Rule:MF_03007};
GN Name=eif3ha; Synonyms=eif3h, eif3s3a;
OS Danio rerio (Zebrafish) (Brachydanio rerio).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes;
OC Danionidae; Danioninae; Danio.
OX NCBI_TaxID=7955;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=Singapore local strain; TISSUE=Embryo;
RG NIH - Zebrafish Gene Collection (ZGC) project;
RL Submitted (AUG-2004) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Component of the eukaryotic translation initiation factor 3
CC (eIF-3) complex, which is involved in protein synthesis of a
CC specialized repertoire of mRNAs and, together with other initiation
CC factors, stimulates binding of mRNA and methionyl-tRNAi to the 40S
CC ribosome. The eIF-3 complex specifically targets and initiates
CC translation of a subset of mRNAs involved in cell proliferation.
CC {ECO:0000255|HAMAP-Rule:MF_03007}.
CC -!- SUBUNIT: Component of the eukaryotic translation initiation factor 3
CC (eIF-3) complex, which is composed of 13 subunits: eif3a, eif3b, eif3c,
CC eif3d, eif3e, eif3f, eif3g, eif3h, eif3i, eif3j, eif3k, eif3l and
CC eif3m. {ECO:0000255|HAMAP-Rule:MF_03007}.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000255|HAMAP-Rule:MF_03007}.
CC -!- SIMILARITY: Belongs to the eIF-3 subunit H family. {ECO:0000255|HAMAP-
CC Rule:MF_03007}.
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DR EMBL; BC079514; AAH79514.1; -; mRNA.
DR RefSeq; NP_001003763.1; NM_001003763.2.
DR AlphaFoldDB; Q6AXJ2; -.
DR SMR; Q6AXJ2; -.
DR STRING; 7955.ENSDARP00000104169; -.
DR MEROPS; M67.971; -.
DR PaxDb; Q6AXJ2; -.
DR PRIDE; Q6AXJ2; -.
DR Ensembl; ENSDART00000159372; ENSDARP00000129950; ENSDARG00000102452.
DR GeneID; 445306; -.
DR KEGG; dre:445306; -.
DR CTD; 445306; -.
DR ZFIN; ZDB-GENE-040808-19; eif3ha.
DR eggNOG; KOG1560; Eukaryota.
DR GeneTree; ENSGT00730000111042; -.
DR HOGENOM; CLU_044094_0_0_1; -.
DR InParanoid; Q6AXJ2; -.
DR OMA; RLETMCA; -.
DR OrthoDB; 976469at2759; -.
DR PhylomeDB; Q6AXJ2; -.
DR TreeFam; TF101504; -.
DR Reactome; R-DRE-156827; L13a-mediated translational silencing of Ceruloplasmin expression.
DR Reactome; R-DRE-72649; Translation initiation complex formation.
DR Reactome; R-DRE-72689; Formation of a pool of free 40S subunits.
DR Reactome; R-DRE-72695; Formation of the ternary complex, and subsequently, the 43S complex.
DR Reactome; R-DRE-72702; Ribosomal scanning and start codon recognition.
DR Reactome; R-DRE-72706; GTP hydrolysis and joining of the 60S ribosomal subunit.
DR PRO; PR:Q6AXJ2; -.
DR Proteomes; UP000000437; Genome assembly.
DR Proteomes; UP000814640; Chromosome 16.
DR Bgee; ENSDARG00000102452; Expressed in pharyngeal gill and 34 other tissues.
DR GO; GO:0016282; C:eukaryotic 43S preinitiation complex; IBA:GO_Central.
DR GO; GO:0033290; C:eukaryotic 48S preinitiation complex; IEA:UniProtKB-UniRule.
DR GO; GO:0005852; C:eukaryotic translation initiation factor 3 complex; ISS:UniProtKB.
DR GO; GO:0042788; C:polysomal ribosome; IBA:GO_Central.
DR GO; GO:0070122; F:isopeptidase activity; IEA:InterPro.
DR GO; GO:0140492; F:metal-dependent deubiquitinase activity; IEA:InterPro.
DR GO; GO:0008237; F:metallopeptidase activity; IBA:GO_Central.
DR GO; GO:0003743; F:translation initiation factor activity; IEA:UniProtKB-UniRule.
DR GO; GO:0007420; P:brain development; IMP:ZFIN.
DR GO; GO:0001732; P:formation of cytoplasmic translation initiation complex; IEA:UniProtKB-UniRule.
DR GO; GO:0048882; P:lateral line development; IMP:ZFIN.
DR GO; GO:0006417; P:regulation of translation; IMP:ZFIN.
DR GO; GO:0006413; P:translational initiation; ISS:UniProtKB.
DR GO; GO:0001944; P:vasculature development; IMP:ZFIN.
DR CDD; cd08065; MPN_eIF3h; 1.
DR HAMAP; MF_03007; eIF3h; 1.
DR InterPro; IPR027524; eIF3h.
DR InterPro; IPR045810; eIF3h_C.
DR InterPro; IPR000555; JAMM/MPN+_dom.
DR InterPro; IPR037518; MPN.
DR PANTHER; PTHR10410:SF3; PTHR10410:SF3; 1.
DR Pfam; PF19445; eIF3h_C; 1.
DR Pfam; PF01398; JAB; 1.
DR SMART; SM00232; JAB_MPN; 1.
DR PROSITE; PS50249; MPN; 1.
PE 2: Evidence at transcript level;
KW Cytoplasm; Initiation factor; Protein biosynthesis; Reference proteome.
FT CHAIN 1..335
FT /note="Eukaryotic translation initiation factor 3 subunit
FT H-A"
FT /id="PRO_0000365176"
FT DOMAIN 22..156
FT /note="MPN"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU01182"
FT REGION 254..282
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 254..273
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 335 AA; 38597 MW; 4715E55BEFCCC19A CRC64;
MASRKESAAS GSNPLDFPVK QIQVDGLVVL KIIKHYQEEG QGSEVVQGVL LGLVVEDRLE
ITNCFPFPQH TEDDVEFDEV QYQMEMMRSL RHVNIDHLHV GWYQSTYYGS FVSRALLDSQ
FSYQHAIEES VVLIYDPLKT AQGSLCLKAY RLTPKLMEIC KEKDFTPEGL KKAAVAYEHM
FEEVPIFIKN SHLINVLMWD LQEKSTLADK HELLNLSSSN HLEKSLQLLM DRVDDMSQDI
VKYNTYCRNL SKQQQQKQQY QQRRQQENAQ RQSRGEPPLP EEDISKMFKA PQAPPRMDTL
LIAGQINNYC QNIKEFTSQN LGKLFMAEAL QSNSS
