ID   EI3HB_DANRE             Reviewed;         333 AA.
AC   Q5PR67; Q3B746;
DT   03-MAR-2009, integrated into UniProtKB/Swiss-Prot.
DT   03-MAR-2009, sequence version 2.
DT   03-AUG-2022, entry version 110.
DE   RecName: Full=Eukaryotic translation initiation factor 3 subunit H-B {ECO:0000255|HAMAP-Rule:MF_03007};
DE            Short=eIF3h-B {ECO:0000255|HAMAP-Rule:MF_03007};
DE   AltName: Full=Eukaryotic translation initiation factor 3 subunit 3-B {ECO:0000255|HAMAP-Rule:MF_03007};
DE   AltName: Full=eIF-3-gamma-B;
DE   AltName: Full=eIF3 p40 subunit B {ECO:0000255|HAMAP-Rule:MF_03007};
GN   Name=eif3hb; Synonyms=eif3s3b; ORFNames=zgc:123049;
OS   Danio rerio (Zebrafish) (Brachydanio rerio).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes;
OC   Danionidae; Danioninae; Danio.
OX   NCBI_TaxID=7955;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Eye, and Heart;
RG   NIH - Zebrafish Gene Collection (ZGC) project;
RL   Submitted (OCT-2005) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Component of the eukaryotic translation initiation factor 3
CC       (eIF-3) complex, which is involved in protein synthesis of a
CC       specialized repertoire of mRNAs and, together with other initiation
CC       factors, stimulates binding of mRNA and methionyl-tRNAi to the 40S
CC       ribosome. The eIF-3 complex specifically targets and initiates
CC       translation of a subset of mRNAs involved in cell proliferation.
CC       {ECO:0000255|HAMAP-Rule:MF_03007}.
CC   -!- SUBUNIT: Component of the eukaryotic translation initiation factor 3
CC       (eIF-3) complex, which is composed of 13 subunits: eif3a, eif3b, eif3c,
CC       eif3d, eif3e, eif3f, eif3g, eif3h, eif3i, eif3j, eif3k, eif3l and
CC       eif3m. {ECO:0000255|HAMAP-Rule:MF_03007}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000255|HAMAP-Rule:MF_03007}.
CC   -!- SIMILARITY: Belongs to the eIF-3 subunit H family. {ECO:0000255|HAMAP-
CC       Rule:MF_03007}.
CC   -!- SEQUENCE CAUTION:
CC       Sequence=AAH86809.1; Type=Erroneous initiation; Evidence={ECO:0000305};
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DR   EMBL; BC086809; AAH86809.1; ALT_INIT; mRNA.
DR   EMBL; BC107824; AAI07825.1; -; mRNA.
DR   RefSeq; NP_001030341.1; NM_001035264.2.
DR   AlphaFoldDB; Q5PR67; -.
DR   SMR; Q5PR67; -.
DR   STRING; 7955.ENSDARP00000052433; -.
DR   MEROPS; M67.971; -.
DR   PaxDb; Q5PR67; -.
DR   Ensembl; ENSDART00000052434; ENSDARP00000052433; ENSDARG00000036116.
DR   GeneID; 567151; -.
DR   KEGG; dre:567151; -.
DR   CTD; 567151; -.
DR   ZFIN; ZDB-GENE-051030-42; eif3hb.
DR   eggNOG; KOG1560; Eukaryota.
DR   GeneTree; ENSGT00730000111042; -.
DR   HOGENOM; CLU_044094_0_0_1; -.
DR   InParanoid; Q5PR67; -.
DR   OMA; KFNRYQQ; -.
DR   OrthoDB; 976469at2759; -.
DR   PhylomeDB; Q5PR67; -.
DR   PRO; PR:Q5PR67; -.
DR   Proteomes; UP000000437; Genome assembly.
DR   Proteomes; UP000814640; Chromosome 19.
DR   Bgee; ENSDARG00000036116; Expressed in muscle tissue and 28 other tissues.
DR   ExpressionAtlas; Q5PR67; baseline and differential.
DR   GO; GO:0016282; C:eukaryotic 43S preinitiation complex; IBA:GO_Central.
DR   GO; GO:0033290; C:eukaryotic 48S preinitiation complex; IEA:UniProtKB-UniRule.
DR   GO; GO:0005852; C:eukaryotic translation initiation factor 3 complex; ISS:UniProtKB.
DR   GO; GO:0042788; C:polysomal ribosome; IBA:GO_Central.
DR   GO; GO:0070122; F:isopeptidase activity; IEA:InterPro.
DR   GO; GO:0140492; F:metal-dependent deubiquitinase activity; IEA:InterPro.
DR   GO; GO:0008237; F:metallopeptidase activity; IBA:GO_Central.
DR   GO; GO:0003743; F:translation initiation factor activity; IEA:UniProtKB-UniRule.
DR   GO; GO:0007420; P:brain development; IMP:ZFIN.
DR   GO; GO:0001732; P:formation of cytoplasmic translation initiation complex; IEA:UniProtKB-UniRule.
DR   GO; GO:0007507; P:heart development; IMP:ZFIN.
DR   GO; GO:0006413; P:translational initiation; ISS:UniProtKB.
DR   CDD; cd08065; MPN_eIF3h; 1.
DR   HAMAP; MF_03007; eIF3h; 1.
DR   InterPro; IPR027524; eIF3h.
DR   InterPro; IPR045810; eIF3h_C.
DR   InterPro; IPR000555; JAMM/MPN+_dom.
DR   InterPro; IPR037518; MPN.
DR   PANTHER; PTHR10410:SF3; PTHR10410:SF3; 1.
DR   Pfam; PF19445; eIF3h_C; 1.
DR   Pfam; PF01398; JAB; 1.
DR   SMART; SM00232; JAB_MPN; 1.
DR   PROSITE; PS50249; MPN; 1.
PE   2: Evidence at transcript level;
KW   Cytoplasm; Initiation factor; Protein biosynthesis; Reference proteome.
FT   CHAIN           1..333
FT                   /note="Eukaryotic translation initiation factor 3 subunit
FT                   H-B"
FT                   /id="PRO_0000365177"
FT   DOMAIN          20..154
FT                   /note="MPN"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU01182"
FT   REGION          249..295
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        249..271
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   333 AA;  38226 MW;  3AC5531132A40419 CRC64;
     MASRKETPNG KTLDTPVKQI QIEGLVVMKI IKHYQEEGQG SEVVQGVLLG LVVEDQLEIT
     NCFPFPQHTE DDADFDEVQY QMEMMRSLRH VNIDHLHVGW YQSTLYGSFV SRALLDSQFS
     YQHAIEESVV LIYDPIKTAQ GSLCLKAYRL TPKLMEICKE KDFSSEGLKK ASVGYEHMFE
     EVPIVIKNSH LINVLLWELE EKSTAADKHE LLSLSSSSHL EKSLQMLMDR VDDMSQDIVK
     YNNYSRSLSK QQQQKHQYVQ RRQQENAQRQ SRGEPPLPEE DLTKMFKPPQ PPPRMDTLLI
     ASQINTYCQT IKEFTSQNLG KLFMAEALQG PSS