EID2B_HUMAN
ID EID2B_HUMAN Reviewed; 161 AA.
AC Q96D98; Q8N8S0;
DT 15-JAN-2008, integrated into UniProtKB/Swiss-Prot.
DT 01-MAR-2004, sequence version 2.
DT 03-AUG-2022, entry version 128.
DE RecName: Full=EP300-interacting inhibitor of differentiation 2B;
DE Short=EID-2B;
DE AltName: Full=EID-2-like inhibitor of differentiation 3;
DE Short=EID-3;
GN Name=EID2B {ECO:0000312|EMBL:AAH09725.2};
GN Synonyms=EID3 {ECO:0000303|PubMed:15970276};
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1] {ECO:0000312|EMBL:BAC04743.1}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Teratocarcinoma {ECO:0000269|PubMed:14702039};
RX PubMed=14702039; DOI=10.1038/ng1285;
RA Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R.,
RA Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H.,
RA Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.,
RA Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K.,
RA Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H.,
RA Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M.,
RA Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K.,
RA Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T.,
RA Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M.,
RA Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S.,
RA Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H.,
RA Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K.,
RA Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N.,
RA Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S.,
RA Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O.,
RA Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H.,
RA Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B.,
RA Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y.,
RA Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K.,
RA Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T.,
RA Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T.,
RA Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y.,
RA Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H.,
RA Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y.,
RA Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H.,
RA Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O.,
RA Isogai T., Sugano S.;
RT "Complete sequencing and characterization of 21,243 full-length human
RT cDNAs.";
RL Nat. Genet. 36:40-45(2004).
RN [2] {ECO:0000312|EMBL:EAW56908.1}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M.,
RA Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J.,
RA Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S.,
RA Turner R., Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H.,
RA Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K.,
RA Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D.,
RA Hunkapiller M.W., Myers E.W., Venter J.C.;
RL Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases.
RN [3] {ECO:0000312|EMBL:AAH09725.2}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Pancreas {ECO:0000312|EMBL:AAH09725.2};
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [4] {ECO:0000305}
RP NUCLEOTIDE SEQUENCE [MRNA] OF 10-161, FUNCTION, INTERACTION WITH HDAC1 AND
RP HDAC2, SUBUNIT, SUBCELLULAR LOCATION, AND DOMAIN.
RX PubMed=15970276; DOI=10.1016/j.bbrc.2005.06.013;
RA Sasajima Y., Tanaka H., Miyake S., Yuasa Y.;
RT "A novel EID family member, EID-3, inhibits differentiation and forms a
RT homodimer or heterodimer with EID-2.";
RL Biochem. Biophys. Res. Commun. 333:969-975(2005).
CC -!- FUNCTION: Acts as a repressor of MYOD-dependent transcription,
CC glucocorticoid receptor-dependent transcription, and muscle
CC differentiation. {ECO:0000269|PubMed:15970276}.
CC -!- SUBUNIT: Homodimer and heterodimer with EID2. Interacts with HDAC1 and
CC HDAC2. {ECO:0000269|PubMed:15970276}.
CC -!- INTERACTION:
CC Q96D98; P15289: ARSA; NbExp=3; IntAct=EBI-724968, EBI-2117357;
CC Q96D98; Q9UI47-2: CTNNA3; NbExp=3; IntAct=EBI-724968, EBI-11962928;
CC Q96D98; Q8N6I1: EID2; NbExp=2; IntAct=EBI-724968, EBI-5525894;
CC Q96D98; Q96D98: EID2B; NbExp=2; IntAct=EBI-724968, EBI-724968;
CC Q96D98; Q13547: HDAC1; NbExp=2; IntAct=EBI-724968, EBI-301834;
CC Q96D98; Q9HCI5: MAGEE1; NbExp=4; IntAct=EBI-724968, EBI-949966;
CC Q96D98; Q7Z3K3: POGZ; NbExp=3; IntAct=EBI-724968, EBI-1389308;
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:15970276}.
CC -!- DOMAIN: The C-terminal portion of EID2B is required for nuclear
CC localization. {ECO:0000269|PubMed:15970276}.
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DR EMBL; AK096263; BAC04743.1; -; mRNA.
DR EMBL; CH471126; EAW56908.1; -; Genomic_DNA.
DR EMBL; BC009725; AAH09725.2; -; mRNA.
DR CCDS; CCDS12539.1; -.
DR RefSeq; NP_689574.1; NM_152361.2.
DR AlphaFoldDB; Q96D98; -.
DR BioGRID; 125972; 67.
DR IntAct; Q96D98; 11.
DR STRING; 9606.ENSP00000317564; -.
DR iPTMnet; Q96D98; -.
DR PhosphoSitePlus; Q96D98; -.
DR BioMuta; EID2B; -.
DR DMDM; 74731428; -.
DR MassIVE; Q96D98; -.
DR PaxDb; Q96D98; -.
DR PeptideAtlas; Q96D98; -.
DR PRIDE; Q96D98; -.
DR Antibodypedia; 65436; 11 antibodies from 10 providers.
DR DNASU; 126272; -.
DR Ensembl; ENST00000326282.5; ENSP00000317564.4; ENSG00000176401.6.
DR GeneID; 126272; -.
DR KEGG; hsa:126272; -.
DR MANE-Select; ENST00000326282.5; ENSP00000317564.4; NM_152361.3; NP_689574.1.
DR UCSC; uc002olz.1; human.
DR CTD; 126272; -.
DR GeneCards; EID2B; -.
DR HGNC; HGNC:26796; EID2B.
DR HPA; ENSG00000176401; Low tissue specificity.
DR MIM; 617355; gene.
DR neXtProt; NX_Q96D98; -.
DR OpenTargets; ENSG00000176401; -.
DR PharmGKB; PA162384551; -.
DR VEuPathDB; HostDB:ENSG00000176401; -.
DR eggNOG; ENOG502TGX1; Eukaryota.
DR GeneTree; ENSGT00940000154796; -.
DR HOGENOM; CLU_1721807_0_0_1; -.
DR InParanoid; Q96D98; -.
DR OMA; DANPPQM; -.
DR OrthoDB; 1591360at2759; -.
DR PhylomeDB; Q96D98; -.
DR TreeFam; TF337633; -.
DR PathwayCommons; Q96D98; -.
DR SignaLink; Q96D98; -.
DR BioGRID-ORCS; 126272; 19 hits in 1083 CRISPR screens.
DR ChiTaRS; EID2B; human.
DR GenomeRNAi; 126272; -.
DR Pharos; Q96D98; Tdark.
DR PRO; PR:Q96D98; -.
DR Proteomes; UP000005640; Chromosome 19.
DR RNAct; Q96D98; protein.
DR Bgee; ENSG00000176401; Expressed in cerebellar hemisphere and 142 other tissues.
DR Genevisible; Q96D98; HS.
DR GO; GO:0005654; C:nucleoplasm; IBA:GO_Central.
DR GO; GO:0005634; C:nucleus; IMP:UniProtKB.
DR GO; GO:0042802; F:identical protein binding; IPI:IntAct.
DR GO; GO:0003714; F:transcription corepressor activity; IBA:GO_Central.
DR GO; GO:0030154; P:cell differentiation; IEA:UniProtKB-KW.
DR GO; GO:0007517; P:muscle organ development; IEA:UniProtKB-KW.
DR GO; GO:0045662; P:negative regulation of myoblast differentiation; IDA:UniProtKB.
DR GO; GO:0045892; P:negative regulation of transcription, DNA-templated; IDA:UniProtKB.
DR InterPro; IPR033258; EID.
DR InterPro; IPR033259; EID-3.
DR PANTHER; PTHR15556; PTHR15556; 1.
DR PANTHER; PTHR15556:SF4; PTHR15556:SF4; 1.
PE 1: Evidence at protein level;
KW Developmental protein; Differentiation; Myogenesis; Nucleus;
KW Reference proteome; Repressor; Transcription; Transcription regulation.
FT CHAIN 1..161
FT /note="EP300-interacting inhibitor of differentiation 2B"
FT /id="PRO_0000315903"
FT REGION 1..26
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 54..77
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 161 AA; 16985 MW; F378CD438AB12661 CRC64;
MAEPTGLLEM SELPGDSSVP QVGTASGVSD VLRGAVGGGV RVQEAREGPV AEAARSMARM
PGPVPGPIPS SVPGLASAPD PHQQLAFLEI NRQLLFREYL DGSSMIPVRL LRDFEERRRL
FVEGCKAREA AFDADPPQMD FAAVAFTVAL TASEALSPLA D
