ID   EID2_BOVIN              Reviewed;         219 AA.
AC   Q17QW4;
DT   15-JAN-2008, integrated into UniProtKB/Swiss-Prot.
DT   25-JUL-2006, sequence version 1.
DT   03-AUG-2022, entry version 82.
DE   RecName: Full=EP300-interacting inhibitor of differentiation 2;
DE            Short=EID-2;
DE   AltName: Full=CREBBP/EP300 inhibitor 2;
DE   AltName: Full=EID-1-like inhibitor of differentiation 2;
GN   Name=EID2 {ECO:0000312|EMBL:AAI18144.1};
OS   Bos taurus (Bovine).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
OC   Bovinae; Bos.
OX   NCBI_TaxID=9913;
RN   [1] {ECO:0000312|EMBL:AAI18144.1}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   STRAIN=Hereford {ECO:0000312|EMBL:AAI18144.1};
RC   TISSUE=Ascending colon {ECO:0000312|EMBL:AAI18144.1};
RG   NIH - Mammalian Gene Collection (MGC) project;
RL   Submitted (JUN-2006) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Interacts with EP300 and acts as a repressor of MYOD-
CC       dependent transcription and muscle differentiation. Inhibits EP300
CC       histone acetyltransferase activity. Acts as a repressor of TGFB/SMAD
CC       transcriptional responses. May act as a repressor of the TGFB/SMAD3-
CC       dependent signaling by selectively blocking formation of TGFB-induced
CC       SMAD3-SMAD4 complex (By similarity). {ECO:0000250|UniProtKB:Q8N6I1}.
CC   -!- SUBUNIT: Heterodimer with EID2B. Interacts with the C-terminus of
CC       EP300. Interacts with HDAC1 and HDAC2. Interacts with SMAD2, SMAD4 and
CC       with the MH2 domain of SMAD3 (By similarity).
CC       {ECO:0000250|UniProtKB:Q8N6I1}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250|UniProtKB:Q8N6I1}.
CC   -!- DOMAIN: The N-terminal portion of EID2 is required for nuclear
CC       localization. {ECO:0000250|UniProtKB:Q8N6I1}.
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DR   EMBL; BC118143; AAI18144.1; -; mRNA.
DR   RefSeq; NP_001071517.1; NM_001078049.1.
DR   AlphaFoldDB; Q17QW4; -.
DR   STRING; 9913.ENSBTAP00000048116; -.
DR   PaxDb; Q17QW4; -.
DR   PRIDE; Q17QW4; -.
DR   Ensembl; ENSBTAT00000020786; ENSBTAP00000048116; ENSBTAG00000015644.
DR   GeneID; 615269; -.
DR   KEGG; bta:615269; -.
DR   CTD; 163126; -.
DR   VEuPathDB; HostDB:ENSBTAG00000015644; -.
DR   eggNOG; ENOG502RU2W; Eukaryota.
DR   GeneTree; ENSGT00940000154796; -.
DR   HOGENOM; CLU_102589_0_0_1; -.
DR   InParanoid; Q17QW4; -.
DR   OMA; FDAEYMR; -.
DR   OrthoDB; 1475530at2759; -.
DR   TreeFam; TF337633; -.
DR   Proteomes; UP000009136; Chromosome 18.
DR   Bgee; ENSBTAG00000015644; Expressed in retina and 98 other tissues.
DR   GO; GO:0005654; C:nucleoplasm; IBA:GO_Central.
DR   GO; GO:0046332; F:SMAD binding; IEA:Ensembl.
DR   GO; GO:0003714; F:transcription corepressor activity; IBA:GO_Central.
DR   GO; GO:0030154; P:cell differentiation; IEA:UniProtKB-KW.
DR   GO; GO:0007517; P:muscle organ development; IEA:UniProtKB-KW.
DR   GO; GO:0000122; P:negative regulation of transcription by RNA polymerase II; IEA:InterPro.
DR   GO; GO:0045892; P:negative regulation of transcription, DNA-templated; IBA:GO_Central.
DR   GO; GO:0030512; P:negative regulation of transforming growth factor beta receptor signaling pathway; IEA:Ensembl.
DR   GO; GO:0042127; P:regulation of cell population proliferation; IEA:Ensembl.
DR   GO; GO:0007183; P:SMAD protein complex assembly; IEA:Ensembl.
DR   GO; GO:0007181; P:transforming growth factor beta receptor complex assembly; IEA:Ensembl.
DR   InterPro; IPR033258; EID.
DR   InterPro; IPR033256; EID-2.
DR   PANTHER; PTHR15556; PTHR15556; 1.
DR   PANTHER; PTHR15556:SF3; PTHR15556:SF3; 1.
PE   2: Evidence at transcript level;
KW   Developmental protein; Differentiation; Methylation; Myogenesis; Nucleus;
KW   Reference proteome; Repressor; Transcription; Transcription regulation.
FT   CHAIN           1..219
FT                   /note="EP300-interacting inhibitor of differentiation 2"
FT                   /id="PRO_0000315900"
FT   REGION          1..71
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          95..115
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   MOD_RES         75
FT                   /note="Omega-N-methylarginine"
FT                   /evidence="ECO:0000250|UniProtKB:Q8N6I1"
SQ   SEQUENCE   219 AA;  23882 MW;  FCEA847A3B06CBDA CRC64;
     MSELPADQGV PPAGAANDNG DVRQAEVGGR RREPAPAQPV AARDRPMAAA VEGSMASPVE
     GPVPEAREGP MAASREGLGA AAREARMAEV ARLLAEPAEE EGPEGRPRSR PGNGPGLAAL
     PYLRLRHPLG VLGINYQQFL RHYLEHYPIA PGRIQELEGR RRRFVEACRA REAAFDAEYQ
     RNPQRMDFDI LTFSITLTAS EIINPLIEEL GCDKFISRE