ID   EID3_MACFA              Reviewed;         371 AA.
AC   A5LFW4;
DT   15-JAN-2008, integrated into UniProtKB/Swiss-Prot.
DT   10-JUL-2007, sequence version 1.
DT   03-AUG-2022, entry version 41.
DE   RecName: Full=EP300-interacting inhibitor of differentiation 3;
DE            Short=EID-3;
DE   AltName: Full=EID-1-like inhibitor of differentiation 3;
DE   AltName: Full=Non-structural maintenance of chromosomes element 4 homolog B;
DE            Short=NS4EB;
DE            Short=Non-SMC element 4 homolog B;
GN   Name=EID3 {ECO:0000250|UniProtKB:Q8N140}; ORFNames=QtsA-13676;
OS   Macaca fascicularis (Crab-eating macaque) (Cynomolgus monkey).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini;
OC   Cercopithecidae; Cercopithecinae; Macaca.
OX   NCBI_TaxID=9541;
RN   [1] {ECO:0000312|EMBL:BAF63649.1}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Testis {ECO:0000269|Ref.1};
RG   International consortium for macaque cDNA sequencing and analysis;
RT   "DNA sequences of macaque genes expressed in brain or testis and its
RT   evolutionary implications.";
RL   Submitted (JUN-2005) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Tissue-specific component of the SMC5-SMC6 complex, a complex
CC       involved in repair of DNA double-strand breaks by homologous
CC       recombination. The complex may promote sister chromatid homologous
CC       recombination by recruiting the SMC1-SMC3 cohesin complex to double-
CC       strand breaks. The complex is required for telomere maintenance via
CC       recombination and mediates sumoylation of shelterin complex (telosome)
CC       components (By similarity). {ECO:0000250}.
CC   -!- FUNCTION: Acts as a repressor of nuclear receptor-dependent
CC       transcription possibly by interfering with CREBBP-dependent
CC       coactivation. May function as a coinhibitor of other CREBBP/EP300-
CC       dependent transcription factors (By similarity). {ECO:0000250}.
CC   -!- SUBUNIT: Component of the SMC5-SMC6 complex which consists at least of
CC       SMC5, SMC6, NSMCE2, NSMCE1, NSMCE4A or EID3 and NSMCE3. NSMCE1, NSMCE4A
CC       or EID3 and NSMCE3 probably form a subcomplex that bridges the head
CC       domains of the SMC5:SMC6 heterodimer. Homodimer, and heterodimer with
CC       EID2. Interacts with the C-terminal region of CREBBP (By similarity).
CC       {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250|UniProtKB:Q8N140}. Cytoplasm
CC       {ECO:0000250|UniProtKB:Q8N140}. Chromosome, telomere {ECO:0000250}.
CC       Note=May shuttle between nucleus and cytoplasm.
CC       {ECO:0000250|UniProtKB:Q8N140}.
CC   -!- SIMILARITY: Belongs to the NSE4 family. {ECO:0000255}.
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DR   EMBL; AB168632; BAF63649.1; -; mRNA.
DR   RefSeq; NP_001270744.1; NM_001283815.1.
DR   AlphaFoldDB; A5LFW4; -.
DR   STRING; 9541.XP_005595536.1; -.
DR   GeneID; 101866850; -.
DR   CTD; 493861; -.
DR   eggNOG; KOG2866; Eukaryota.
DR   Proteomes; UP000233100; Unplaced.
DR   GO; GO:0000781; C:chromosome, telomeric region; IEA:UniProtKB-SubCell.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0030915; C:Smc5-Smc6 complex; ISS:UniProtKB.
DR   GO; GO:0006310; P:DNA recombination; IEA:UniProtKB-KW.
DR   GO; GO:0006281; P:DNA repair; IEA:UniProtKB-KW.
DR   InterPro; IPR027786; Nse4/EID.
DR   InterPro; IPR014854; Nse4_C.
DR   InterPro; IPR029225; Nse4_Nse3-bd.
DR   PANTHER; PTHR16140; PTHR16140; 1.
DR   Pfam; PF15412; Nse4-Nse3_bdg; 1.
DR   Pfam; PF08743; Nse4_C; 1.
PE   2: Evidence at transcript level;
KW   Chromosome; Cytoplasm; DNA damage; DNA recombination; DNA repair; Nucleus;
KW   Reference proteome; Repressor; Telomere; Transcription;
KW   Transcription regulation.
FT   CHAIN           1..371
FT                   /note="EP300-interacting inhibitor of differentiation 3"
FT                   /id="PRO_0000315906"
SQ   SEQUENCE   371 AA;  42021 MW;  6660B764B44150C5 CRC64;
     MSVEKASRKG DDEKGEEQLV VIPSSEYAAK PAAAEGAPMK MDVAVRVTGC SDDLSSGDAD
     IDPKLLELTA DEEKCRSIRR QYRQLMYCVR QNRGDIVNSA NNSLTEALEE ANVLFDGVSR
     TREAALDAQF LVMASDLGKE KAKQLNSDLN FFNQLAFCDF LFLFGGLNWM EGEPDDLSDC
     DDNIALSFWK AMEKEATSWM VKAETFHFVF GSFKLEPSAP KPRLEHQKKV RKMEENGNMP
     TKLRKLDLSS YPEATEKNVE RILGLLQTYF RKYPDTPVSY FEFVIDPNSF SRTVENIFYV
     SFIVRDGFAR IRLDEDRLPI LEPMNVNQMG EGNDSSCHGR KQGVISLTLQ EWKNIVAAFE
     ISEAMITYSS Y