EIF1A_BOVIN
ID EIF1A_BOVIN Reviewed; 166 AA.
AC Q58CY2; Q0VCL0; Q27HF3;
DT 15-JAN-2008, integrated into UniProtKB/Swiss-Prot.
DT 26-APR-2005, sequence version 1.
DT 03-AUG-2022, entry version 94.
DE RecName: Full=Probable RNA-binding protein EIF1AD;
DE AltName: Full=Eukaryotic translation initiation factor 1A domain-containing protein;
GN Name=EIF1AD;
OS Bos taurus (Bovine).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
OC Bovinae; Bos.
OX NCBI_TaxID=9913;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RX PubMed=16305752; DOI=10.1186/1471-2164-6-166;
RA Harhay G.P., Sonstegard T.S., Keele J.W., Heaton M.P., Clawson M.L.,
RA Snelling W.M., Wiedmann R.T., Van Tassell C.P., Smith T.P.L.;
RT "Characterization of 954 bovine full-CDS cDNA sequences.";
RL BMC Genomics 6:166-166(2005).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=Hereford; TISSUE=Fetal pons;
RG NIH - Mammalian Gene Collection (MGC) project;
RL Submitted (AUG-2006) to the EMBL/GenBank/DDBJ databases.
RN [3]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 30-166.
RA Heaton M.P., Clawson M.L., Snelling W.M., Keele J.W., Harhay G.P.,
RA Wiedmann R.T., Bennett G.L., Smith T.P.L., Freking B.A., Van Tassell C.P.,
RA Sonstegard T.S., Gasbarre L.C., Moore S.S., Murdoch B., McKay S.D.,
RA Kalbfleisch T., Laegreid W.W.;
RT "Estimating probability of parentage in U.S. beef and dairy cattle with
RT single nucleotide polymorphisms.";
RL Submitted (FEB-2006) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Plays a role into cellular response to oxidative stress.
CC Decreases cell proliferation (By similarity). {ECO:0000250}.
CC -!- SUBUNIT: Interacts with GAPDH and STAT1. {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250}.
CC -!- SIMILARITY: Belongs to the EIF1AD family. {ECO:0000305}.
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DR EMBL; BT021815; AAX46662.1; -; mRNA.
DR EMBL; BC120113; AAI20114.1; -; mRNA.
DR EMBL; DQ404153; ABD57202.1; -; Genomic_DNA.
DR RefSeq; NP_001069861.1; NM_001076393.1.
DR AlphaFoldDB; Q58CY2; -.
DR SMR; Q58CY2; -.
DR STRING; 9913.ENSBTAP00000026889; -.
DR PaxDb; Q58CY2; -.
DR PRIDE; Q58CY2; -.
DR Ensembl; ENSBTAT00000026889; ENSBTAP00000026889; ENSBTAG00000020186.
DR GeneID; 615726; -.
DR KEGG; bta:615726; -.
DR CTD; 84285; -.
DR VEuPathDB; HostDB:ENSBTAG00000020186; -.
DR VGNC; VGNC:28377; EIF1AD.
DR eggNOG; KOG2925; Eukaryota.
DR GeneTree; ENSGT00390000011180; -.
DR HOGENOM; CLU_106477_2_1_1; -.
DR InParanoid; Q58CY2; -.
DR OMA; YLVSMPR; -.
DR OrthoDB; 1431625at2759; -.
DR TreeFam; TF314439; -.
DR Proteomes; UP000009136; Chromosome 29.
DR Bgee; ENSBTAG00000020186; Expressed in oocyte and 103 other tissues.
DR ExpressionAtlas; Q58CY2; baseline and differential.
DR GO; GO:0005634; C:nucleus; IBA:GO_Central.
DR GO; GO:0031090; C:organelle membrane; IEA:UniProt.
DR GO; GO:0003723; F:RNA binding; IEA:UniProtKB-KW.
DR GO; GO:0003743; F:translation initiation factor activity; IEA:InterPro.
DR Gene3D; 2.40.50.140; -; 1.
DR InterPro; IPR039294; EIF1AD.
DR InterPro; IPR012340; NA-bd_OB-fold.
DR InterPro; IPR006196; RNA-binding_domain_S1_IF1.
DR InterPro; IPR001253; TIF_eIF-1A.
DR PANTHER; PTHR21641; PTHR21641; 1.
DR Pfam; PF01176; eIF-1a; 1.
DR SMART; SM00652; eIF1a; 1.
DR SUPFAM; SSF50249; SSF50249; 1.
DR PROSITE; PS50832; S1_IF1_TYPE; 1.
PE 2: Evidence at transcript level;
KW Nucleus; Phosphoprotein; Reference proteome; RNA-binding.
FT CHAIN 1..166
FT /note="Probable RNA-binding protein EIF1AD"
FT /id="PRO_0000314150"
FT DOMAIN 5..89
FT /note="S1-like"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00181"
FT REGION 99..166
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT MOTIF 6..12
FT /note="Nuclear localization signal"
FT /evidence="ECO:0000255"
FT MOTIF 56..65
FT /note="Nuclear localization signal"
FT /evidence="ECO:0000255"
FT MOD_RES 33
FT /note="Phosphothreonine"
FT /evidence="ECO:0000250|UniProtKB:Q8N9N8"
FT MOD_RES 132
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:Q3THJ3"
FT MOD_RES 136
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:Q5RKI6"
FT MOD_RES 137
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:Q3THJ3"
FT MOD_RES 138
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:Q5RKI6"
FT MOD_RES 156
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:Q8N9N8"
FT MOD_RES 160
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:Q8N9N8"
FT CONFLICT 28
FT /note="V -> M (in Ref. 2; AAI20114)"
FT /evidence="ECO:0000305"
FT CONFLICT 125
FT /note="L -> F (in Ref. 2; AAI20114)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 166 AA; 19143 MW; 0265B3786D5594AB CRC64;
MSQATKRKHV VKEVLGEHMV PSDQQQIVRV LRTPGNNLHE VETAQGQRFL VSMPSKYRKN
IWIKRGDFLI VDPIEEGEKV KAEISFVLCK DHVRSLQKDG HWPEAFSQVT EKDNNDRNRQ
TQPELPAEPQ SSGEESSSED DSDLFVNTNR RQYHESEEES EEEEAA
