AFT2_CANAL
ID AFT2_CANAL Reviewed; 798 AA.
AC Q59Z29; A0A1D8PHY4;
DT 26-JUN-2013, integrated into UniProtKB/Swiss-Prot.
DT 15-MAR-2017, sequence version 2.
DT 03-AUG-2022, entry version 81.
DE RecName: Full=Iron-regulated transcriptional activator AFT2;
DE AltName: Full=Activator of iron transcription protein 2;
GN Name=AFT2; OrderedLocusNames=CAALFM_C207170CA;
GN ORFNames=CaO19.2272, CaO19.9812;
OS Candida albicans (strain SC5314 / ATCC MYA-2876) (Yeast).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC Saccharomycetales; Debaryomycetaceae; Candida/Lodderomyces clade; Candida.
OX NCBI_TaxID=237561;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=SC5314 / ATCC MYA-2876;
RX PubMed=15123810; DOI=10.1073/pnas.0401648101;
RA Jones T., Federspiel N.A., Chibana H., Dungan J., Kalman S., Magee B.B.,
RA Newport G., Thorstenson Y.R., Agabian N., Magee P.T., Davis R.W.,
RA Scherer S.;
RT "The diploid genome sequence of Candida albicans.";
RL Proc. Natl. Acad. Sci. U.S.A. 101:7329-7334(2004).
RN [2]
RP GENOME REANNOTATION.
RC STRAIN=SC5314 / ATCC MYA-2876;
RX PubMed=17419877; DOI=10.1186/gb-2007-8-4-r52;
RA van het Hoog M., Rast T.J., Martchenko M., Grindle S., Dignard D.,
RA Hogues H., Cuomo C., Berriman M., Scherer S., Magee B.B., Whiteway M.,
RA Chibana H., Nantel A., Magee P.T.;
RT "Assembly of the Candida albicans genome into sixteen supercontigs aligned
RT on the eight chromosomes.";
RL Genome Biol. 8:RESEARCH52.1-RESEARCH52.12(2007).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA], AND GENOME REANNOTATION.
RC STRAIN=SC5314 / ATCC MYA-2876;
RX PubMed=24025428; DOI=10.1186/gb-2013-14-9-r97;
RA Muzzey D., Schwartz K., Weissman J.S., Sherlock G.;
RT "Assembly of a phased diploid Candida albicans genome facilitates allele-
RT specific measurements and provides a simple model for repeat and indel
RT structure.";
RL Genome Biol. 14:RESEARCH97.1-RESEARCH97.14(2013).
RN [4]
RP FUNCTION.
RX PubMed=20595261; DOI=10.1099/mic.0.037978-0;
RA Liang Y., Wei D., Wang H., Xu N., Zhang B., Xing L., Li M.;
RT "Role of Candida albicans Aft2p transcription factor in ferric reductase
RT activity, morphogenesis and virulence.";
RL Microbiology 156:2912-2919(2010).
RN [5]
RP FUNCTION, AND DISRUPTION PHENOTYPE.
RX PubMed=23626810; DOI=10.1371/journal.pone.0062367;
RA Xu N., Cheng X., Yu Q., Qian K., Ding X., Liu R., Zhang B., Xing L., Li M.;
RT "Aft2, a novel transcription regulator, is required for iron metabolism,
RT oxidative stress, surface adhesion and hyphal development in Candida
RT albicans.";
RL PLoS ONE 8:E62367-E62367(2013).
CC -!- FUNCTION: Transcription factor involved in iron metabolism, oxidative
CC stress, surface adhesion, hyphal development and virulence. Functions
CC as a negative regulator of MRS4 expression through the CACCC AFT-type
CC sequence in a gene dose-dependent fashion. Acts as a repressor in
CC flocculation, plastic adhesion, and surface hydrophobicity.
CC {ECO:0000269|PubMed:20595261, ECO:0000269|PubMed:23626810}.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000305}.
CC -!- DISRUPTION PHENOTYPE: Leads to hypersensitivity to oxidative stress.
CC {ECO:0000269|PubMed:23626810}.
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DR EMBL; CP017624; AOW27715.1; -; Genomic_DNA.
DR RefSeq; XP_714862.2; XM_709769.2.
DR AlphaFoldDB; Q59Z29; -.
DR SMR; Q59Z29; -.
DR BioGRID; 1226605; 2.
DR STRING; 237561.Q59Z29; -.
DR PRIDE; Q59Z29; -.
DR GeneID; 3643511; -.
DR KEGG; cal:CAALFM_C207170CA; -.
DR CGD; CAL0000183427; AFT2.
DR VEuPathDB; FungiDB:C2_07170C_A; -.
DR eggNOG; KOG4818; Eukaryota.
DR HOGENOM; CLU_363283_0_0_1; -.
DR InParanoid; Q59Z29; -.
DR OrthoDB; 1501881at2759; -.
DR PHI-base; PHI:2555; -.
DR PRO; PR:Q59Z29; -.
DR Proteomes; UP000000559; Chromosome 2.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0000981; F:DNA-binding transcription factor activity, RNA polymerase II-specific; IEA:InterPro.
DR GO; GO:0007155; P:cell adhesion; IEA:UniProtKB-KW.
DR GO; GO:0036086; P:positive regulation of transcription from RNA polymerase II promoter in response to iron ion starvation; IEA:InterPro.
DR InterPro; IPR014842; AFT.
DR Pfam; PF08731; AFT; 1.
PE 4: Predicted;
KW Cell adhesion; Iron; Nucleus; Reference proteome; Transcription;
KW Transcription regulation; Virulence.
FT CHAIN 1..798
FT /note="Iron-regulated transcriptional activator AFT2"
FT /id="PRO_0000422795"
FT REGION 142..274
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 331..365
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 449..545
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 642..718
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 748..798
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 149..168
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 187..241
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 253..270
FT /note="Basic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 476..545
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 748..791
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 798 AA; 88031 MW; AA3A417CE37152E2 CRC64;
MTDRVTHRVS LDDLNLEKQK FDSKDDIKPW LQDNLQSTKG INVVIERSDT SKIIFKCKNK
EKKTKIVESK KTASKTMIRK HTSCPFKIRA NYSVRNKVWT LSIVSDEHDH VVDLPRSFVG
KNLISNTIPG SSLNVLDSVA PRSNKKGIKP TSEIANTPSV TSYSPSCAVK RNEDVDAPKI
SSKKARNLTK KPSTQSTRSS SSSDGSSIVS FGSLTSQSSS TSLPENYKGQ VPTSMDSMVV
EESLTGKSLK PAASHPVKRK NMKANTMKKS KKLKQNPIVV SPIEEDSNLN SFDDANIDLQ
RQQSLQSPLS HLVQNQDPIS LEQNPQLHTV YPQPRHSKQS SSLLKKNQQQ DRIPDNMPLQ
PQENNRTLQN FPLNQFNANE ILQNVQQVVR ETVKSEILDS PNIDNTYKTD MMDSFVSSVI
LDYKDYLSSQ FLFSLKQNLY DRREATHTNV DLEQNGSNEN LFDEQPQHKH NHQHNENQFS
YQSQIQNQRQ NQNQNQGQNQ NQNQSQSQTP GQNSNQNDSQ TQIPLQSQTP QDRKSAMQQN
WLPGSTPGVG GLIRLSPLLN DNDNNEYAAV AAAAVVGSTP GNPNGNSLEN FTHLPGINSS
TLNYLMQLPH PSANPNSGGV SSSQPASLMS LQGHQGLLQQ QQQQQPMFSM QNSGQQLPPL
SSIPKLPSSN NANVNLNSSS TLPLPLNNTG PTLNPSSLLK STSRNSTNSG NINVNNINNS
NNNSNSAFNS VFLNSSITTN PAFIFNSQGN PTNSNQSMVN SIMTTNSNKD GTATSNNNSS
GNTSNNLLND MPNYGPGW
