EIF1A_CHICK
ID EIF1A_CHICK Reviewed; 188 AA.
AC Q6K1L7;
DT 15-JAN-2008, integrated into UniProtKB/Swiss-Prot.
DT 05-JUL-2004, sequence version 1.
DT 03-AUG-2022, entry version 82.
DE RecName: Full=Probable RNA-binding protein EIF1AD;
DE AltName: Full=Eukaryotic translation initiation factor 1A domain-containing protein;
DE AltName: Full=Protein Obelix;
GN Name=eif1ad;
OS Gallus gallus (Chicken).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda;
OC Coelurosauria; Aves; Neognathae; Galloanserae; Galliformes; Phasianidae;
OC Phasianinae; Gallus.
OX NCBI_TaxID=9031;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA], SUBCELLULAR LOCATION, AND DEVELOPMENTAL STAGE.
RX PubMed=21559472; DOI=10.1371/journal.pone.0019157;
RA Pinho S., Simonsson P.R., Trevers K.E., Stower M.J., Sherlock W.T.,
RA Khan M., Streit A., Sheng G., Stern C.D.;
RT "Distinct steps of neural induction revealed by Asterix, Obelix and TrkC,
RT genes induced by different signals from the organizer.";
RL PLoS ONE 6:E19157-E19157(2011).
CC -!- FUNCTION: May play a role into cellular response to oxidative stress.
CC May decrease cell proliferation (By similarity). {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:21559472}.
CC -!- DEVELOPMENTAL STAGE: Expressed in the early neural plate of embryos.
CC Expressed at the mid- to late-primitive-streak at stage 3. Expressed at
CC the neuronal plate including streams of neural creast cells until at
CC least stage 14. {ECO:0000269|PubMed:21559472}.
CC -!- SIMILARITY: Belongs to the EIF1AD family. {ECO:0000305}.
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DR EMBL; AY103477; AAM70512.1; -; mRNA.
DR RefSeq; NP_001001612.1; NM_001001612.1.
DR AlphaFoldDB; Q6K1L7; -.
DR SMR; Q6K1L7; -.
DR GeneID; 414740; -.
DR CTD; 84285; -.
DR InParanoid; Q6K1L7; -.
DR OrthoDB; 1431625at2759; -.
DR PhylomeDB; Q6K1L7; -.
DR PRO; PR:Q6K1L7; -.
DR Proteomes; UP000000539; Unplaced.
DR GO; GO:0005634; C:nucleus; IBA:GO_Central.
DR GO; GO:0003723; F:RNA binding; IEA:UniProtKB-KW.
DR GO; GO:0003743; F:translation initiation factor activity; IEA:InterPro.
DR Gene3D; 2.40.50.140; -; 1.
DR InterPro; IPR039294; EIF1AD.
DR InterPro; IPR012340; NA-bd_OB-fold.
DR InterPro; IPR006196; RNA-binding_domain_S1_IF1.
DR InterPro; IPR001253; TIF_eIF-1A.
DR PANTHER; PTHR21641; PTHR21641; 1.
DR Pfam; PF01176; eIF-1a; 1.
DR SMART; SM00652; eIF1a; 1.
DR SUPFAM; SSF50249; SSF50249; 1.
DR PROSITE; PS50832; S1_IF1_TYPE; 1.
PE 2: Evidence at transcript level;
KW Nucleus; Reference proteome; RNA-binding.
FT CHAIN 1..188
FT /note="Probable RNA-binding protein EIF1AD"
FT /id="PRO_0000314156"
FT DOMAIN 14..92
FT /note="S1-like"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00181"
FT REGION 107..188
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 134..160
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 188 AA; 21235 MW; 02594DF74508F53B CRC64;
MSRATKRKHV TREVLEEHVV PAPQQRIVRV LGSPGNNLHE VETADGSRFL ASMPPRFRHH
VWIKRGDFLL VDPIEEGAKV KAEMALVLLR PHVRFLQRQG LWPTAFAASP DRTPQESDGD
SELFVNTNRA TIETDTEEEE EDGGDTESSE EEEEDREEPL EDRPEDRPED CADVGSAAQR
RSTIETGT