位置:首页 > 蛋白库 > EIF1A_CHICK
EIF1A_CHICK
ID   EIF1A_CHICK             Reviewed;         188 AA.
AC   Q6K1L7;
DT   15-JAN-2008, integrated into UniProtKB/Swiss-Prot.
DT   05-JUL-2004, sequence version 1.
DT   03-AUG-2022, entry version 82.
DE   RecName: Full=Probable RNA-binding protein EIF1AD;
DE   AltName: Full=Eukaryotic translation initiation factor 1A domain-containing protein;
DE   AltName: Full=Protein Obelix;
GN   Name=eif1ad;
OS   Gallus gallus (Chicken).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda;
OC   Coelurosauria; Aves; Neognathae; Galloanserae; Galliformes; Phasianidae;
OC   Phasianinae; Gallus.
OX   NCBI_TaxID=9031;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA], SUBCELLULAR LOCATION, AND DEVELOPMENTAL STAGE.
RX   PubMed=21559472; DOI=10.1371/journal.pone.0019157;
RA   Pinho S., Simonsson P.R., Trevers K.E., Stower M.J., Sherlock W.T.,
RA   Khan M., Streit A., Sheng G., Stern C.D.;
RT   "Distinct steps of neural induction revealed by Asterix, Obelix and TrkC,
RT   genes induced by different signals from the organizer.";
RL   PLoS ONE 6:E19157-E19157(2011).
CC   -!- FUNCTION: May play a role into cellular response to oxidative stress.
CC       May decrease cell proliferation (By similarity). {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:21559472}.
CC   -!- DEVELOPMENTAL STAGE: Expressed in the early neural plate of embryos.
CC       Expressed at the mid- to late-primitive-streak at stage 3. Expressed at
CC       the neuronal plate including streams of neural creast cells until at
CC       least stage 14. {ECO:0000269|PubMed:21559472}.
CC   -!- SIMILARITY: Belongs to the EIF1AD family. {ECO:0000305}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; AY103477; AAM70512.1; -; mRNA.
DR   RefSeq; NP_001001612.1; NM_001001612.1.
DR   AlphaFoldDB; Q6K1L7; -.
DR   SMR; Q6K1L7; -.
DR   GeneID; 414740; -.
DR   CTD; 84285; -.
DR   InParanoid; Q6K1L7; -.
DR   OrthoDB; 1431625at2759; -.
DR   PhylomeDB; Q6K1L7; -.
DR   PRO; PR:Q6K1L7; -.
DR   Proteomes; UP000000539; Unplaced.
DR   GO; GO:0005634; C:nucleus; IBA:GO_Central.
DR   GO; GO:0003723; F:RNA binding; IEA:UniProtKB-KW.
DR   GO; GO:0003743; F:translation initiation factor activity; IEA:InterPro.
DR   Gene3D; 2.40.50.140; -; 1.
DR   InterPro; IPR039294; EIF1AD.
DR   InterPro; IPR012340; NA-bd_OB-fold.
DR   InterPro; IPR006196; RNA-binding_domain_S1_IF1.
DR   InterPro; IPR001253; TIF_eIF-1A.
DR   PANTHER; PTHR21641; PTHR21641; 1.
DR   Pfam; PF01176; eIF-1a; 1.
DR   SMART; SM00652; eIF1a; 1.
DR   SUPFAM; SSF50249; SSF50249; 1.
DR   PROSITE; PS50832; S1_IF1_TYPE; 1.
PE   2: Evidence at transcript level;
KW   Nucleus; Reference proteome; RNA-binding.
FT   CHAIN           1..188
FT                   /note="Probable RNA-binding protein EIF1AD"
FT                   /id="PRO_0000314156"
FT   DOMAIN          14..92
FT                   /note="S1-like"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00181"
FT   REGION          107..188
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        134..160
FT                   /note="Acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   188 AA;  21235 MW;  02594DF74508F53B CRC64;
     MSRATKRKHV TREVLEEHVV PAPQQRIVRV LGSPGNNLHE VETADGSRFL ASMPPRFRHH
     VWIKRGDFLL VDPIEEGAKV KAEMALVLLR PHVRFLQRQG LWPTAFAASP DRTPQESDGD
     SELFVNTNRA TIETDTEEEE EDGGDTESSE EEEEDREEPL EDRPEDRPED CADVGSAAQR
     RSTIETGT
 
 
维奥蛋白资源库 - 中文蛋白资源 CopyRight © 2010-2024