EIF1A_PONAB
ID EIF1A_PONAB Reviewed; 166 AA.
AC Q5RD29;
DT 15-JAN-2008, integrated into UniProtKB/Swiss-Prot.
DT 21-DEC-2004, sequence version 1.
DT 03-AUG-2022, entry version 95.
DE RecName: Full=Probable RNA-binding protein EIF1AD;
DE AltName: Full=Eukaryotic translation initiation factor 1A domain-containing protein;
GN Name=EIF1AD;
OS Pongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Pongo.
OX NCBI_TaxID=9601;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Kidney;
RG The German cDNA consortium;
RL Submitted (NOV-2004) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Plays a role into cellular response to oxidative stress.
CC Decreases cell proliferation (By similarity). {ECO:0000250}.
CC -!- SUBUNIT: Interacts with GAPDH and STAT1. {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250}.
CC -!- SIMILARITY: Belongs to the EIF1AD family. {ECO:0000305}.
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DR EMBL; CR858089; CAH90328.1; -; mRNA.
DR RefSeq; NP_001127270.1; NM_001133798.1.
DR RefSeq; XP_002833668.1; XM_002833622.3.
DR AlphaFoldDB; Q5RD29; -.
DR SMR; Q5RD29; -.
DR STRING; 9601.ENSPPYP00000004689; -.
DR Ensembl; ENSPPYT00000049112; ENSPPYP00000038308; ENSPPYG00000032041.
DR GeneID; 100174327; -.
DR KEGG; pon:100174327; -.
DR CTD; 84285; -.
DR eggNOG; KOG2925; Eukaryota.
DR GeneTree; ENSGT00390000011180; -.
DR HOGENOM; CLU_106477_2_1_1; -.
DR InParanoid; Q5RD29; -.
DR OMA; YLVSMPR; -.
DR OrthoDB; 1431625at2759; -.
DR TreeFam; TF314439; -.
DR Proteomes; UP000001595; Chromosome 11.
DR GO; GO:0005829; C:cytosol; IEA:Ensembl.
DR GO; GO:0005654; C:nucleoplasm; IEA:Ensembl.
DR GO; GO:0003723; F:RNA binding; IEA:UniProtKB-KW.
DR GO; GO:0003743; F:translation initiation factor activity; IEA:InterPro.
DR Gene3D; 2.40.50.140; -; 1.
DR InterPro; IPR039294; EIF1AD.
DR InterPro; IPR012340; NA-bd_OB-fold.
DR InterPro; IPR006196; RNA-binding_domain_S1_IF1.
DR InterPro; IPR001253; TIF_eIF-1A.
DR PANTHER; PTHR21641; PTHR21641; 1.
DR Pfam; PF01176; eIF-1a; 1.
DR SMART; SM00652; eIF1a; 1.
DR SUPFAM; SSF50249; SSF50249; 1.
DR PROSITE; PS50832; S1_IF1_TYPE; 1.
PE 2: Evidence at transcript level;
KW Nucleus; Phosphoprotein; Reference proteome; RNA-binding.
FT CHAIN 1..166
FT /note="Probable RNA-binding protein EIF1AD"
FT /id="PRO_0000314154"
FT DOMAIN 5..89
FT /note="S1-like"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00181"
FT REGION 114..166
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT MOTIF 6..12
FT /note="Nuclear localization signal"
FT /evidence="ECO:0000255"
FT MOTIF 56..65
FT /note="Nuclear localization signal"
FT /evidence="ECO:0000255"
FT COMPBIAS 119..133
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT MOD_RES 33
FT /note="Phosphothreonine"
FT /evidence="ECO:0000250|UniProtKB:Q8N9N8"
FT MOD_RES 132
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:Q3THJ3"
FT MOD_RES 136
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:Q5RKI6"
FT MOD_RES 137
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:Q3THJ3"
FT MOD_RES 138
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:Q5RKI6"
FT MOD_RES 156
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:Q8N9N8"
FT MOD_RES 160
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:Q8N9N8"
SQ SEQUENCE 166 AA; 19186 MW; 4E70C2B72521116C CRC64;
MSQATKRKHV VKEVLGEHIV PSDQQQIVRV LRTPGNNLHE VETAQGQRFL VSMPSKYRKN
IWIKRGDFLI VDPIEEGEKV KAEISFVLCK DHVRSLQKEG FWPEAFSEVA EKHNNNRNRQ
TQPELPAEPQ LSGEESSSED DSDLFVNTNR RQYRESEEES EEEEAA
