EIF1B_HUMAN
ID EIF1B_HUMAN Reviewed; 113 AA.
AC O60739; Q9UQF8;
DT 30-MAY-2000, integrated into UniProtKB/Swiss-Prot.
DT 01-DEC-2000, sequence version 2.
DT 03-AUG-2022, entry version 170.
DE RecName: Full=Eukaryotic translation initiation factor 1b;
DE Short=eIF1b;
DE AltName: Full=Protein translation factor SUI1 homolog GC20;
GN Name=EIF1B;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA].
RC TISSUE=Blood;
RA Zhao Z., Huang X., Li N., Zhu X., Cao X.;
RT "Human dendritic cell SUI1 homolog gene.";
RL Submitted (MAY-1998) to the EMBL/GenBank/DDBJ databases.
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Pituitary;
RX PubMed=10931946; DOI=10.1073/pnas.160270997;
RA Hu R.-M., Han Z.-G., Song H.-D., Peng Y.-D., Huang Q.-H., Ren S.-X.,
RA Gu Y.-J., Huang C.-H., Li Y.-B., Jiang C.-L., Fu G., Zhang Q.-H., Gu B.-W.,
RA Dai M., Mao Y.-F., Gao G.-F., Rong R., Ye M., Zhou J., Xu S.-H., Gu J.,
RA Shi J.-X., Jin W.-R., Zhang C.-K., Wu T.-M., Huang G.-Y., Chen Z.,
RA Chen M.-D., Chen J.-L.;
RT "Gene expression profiling in the human hypothalamus-pituitary-adrenal axis
RT and full-length cDNA cloning.";
RL Proc. Natl. Acad. Sci. U.S.A. 97:9543-9548(2000).
RN [3]
RP NUCLEOTIDE SEQUENCE [MRNA].
RC TISSUE=Liver;
RA Kim D.-G., You K.-R.;
RT "Homo sapiens translational factor eIF-1.";
RL Submitted (MAY-2000) to the EMBL/GenBank/DDBJ databases.
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Kidney;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [5]
RP ACETYLATION [LARGE SCALE ANALYSIS] AT SER-2, PHOSPHORYLATION [LARGE SCALE
RP ANALYSIS] AT SER-9, CLEAVAGE OF INITIATOR METHIONINE [LARGE SCALE
RP ANALYSIS], AND IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RX PubMed=21406692; DOI=10.1126/scisignal.2001570;
RA Rigbolt K.T., Prokhorova T.A., Akimov V., Henningsen J., Johansen P.T.,
RA Kratchmarova I., Kassem M., Mann M., Olsen J.V., Blagoev B.;
RT "System-wide temporal characterization of the proteome and phosphoproteome
RT of human embryonic stem cell differentiation.";
RL Sci. Signal. 4:RS3-RS3(2011).
RN [6]
RP PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-9, AND IDENTIFICATION BY MASS
RP SPECTROMETRY [LARGE SCALE ANALYSIS].
RC TISSUE=Erythroleukemia;
RX PubMed=23186163; DOI=10.1021/pr300630k;
RA Zhou H., Di Palma S., Preisinger C., Peng M., Polat A.N., Heck A.J.,
RA Mohammed S.;
RT "Toward a comprehensive characterization of a human cancer cell
RT phosphoproteome.";
RL J. Proteome Res. 12:260-271(2013).
CC -!- FUNCTION: Probably involved in translation.
CC -!- INTERACTION:
CC O60739; Q92997: DVL3; NbExp=3; IntAct=EBI-1043343, EBI-739789;
CC O60739; P35637: FUS; NbExp=3; IntAct=EBI-1043343, EBI-400434;
CC O60739; Q9NZD8: SPG21; NbExp=3; IntAct=EBI-1043343, EBI-742688;
CC O60739; P09936: UCHL1; NbExp=3; IntAct=EBI-1043343, EBI-714860;
CC -!- SIMILARITY: Belongs to the SUI1 family. {ECO:0000305}.
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DR EMBL; AF064607; AAC17112.1; -; mRNA.
DR EMBL; AF077052; AAD27785.1; -; mRNA.
DR EMBL; AF263452; AAF79182.1; -; mRNA.
DR EMBL; BC006996; AAH06996.1; -; mRNA.
DR CCDS; CCDS2690.1; -.
DR RefSeq; NP_005866.1; NM_005875.2.
DR AlphaFoldDB; O60739; -.
DR SMR; O60739; -.
DR BioGRID; 115578; 54.
DR IntAct; O60739; 13.
DR MINT; O60739; -.
DR STRING; 9606.ENSP00000232905; -.
DR GlyGen; O60739; 1 site, 1 O-linked glycan (1 site).
DR iPTMnet; O60739; -.
DR PhosphoSitePlus; O60739; -.
DR SwissPalm; O60739; -.
DR BioMuta; EIF1B; -.
DR EPD; O60739; -.
DR jPOST; O60739; -.
DR MassIVE; O60739; -.
DR PaxDb; O60739; -.
DR PeptideAtlas; O60739; -.
DR PRIDE; O60739; -.
DR ProteomicsDB; 49582; -.
DR TopDownProteomics; O60739; -.
DR Antibodypedia; 65170; 93 antibodies from 22 providers.
DR DNASU; 10289; -.
DR Ensembl; ENST00000232905.4; ENSP00000232905.3; ENSG00000114784.4.
DR GeneID; 10289; -.
DR KEGG; hsa:10289; -.
DR MANE-Select; ENST00000232905.4; ENSP00000232905.3; NM_005875.3; NP_005866.1.
DR CTD; 10289; -.
DR GeneCards; EIF1B; -.
DR HGNC; HGNC:30792; EIF1B.
DR HPA; ENSG00000114784; Tissue enhanced (heart).
DR neXtProt; NX_O60739; -.
DR OpenTargets; ENSG00000114784; -.
DR PharmGKB; PA143485452; -.
DR VEuPathDB; HostDB:ENSG00000114784; -.
DR eggNOG; KOG1770; Eukaryota.
DR GeneTree; ENSGT00940000160239; -.
DR HOGENOM; CLU_082805_3_0_1; -.
DR InParanoid; O60739; -.
DR OMA; CEFMITQ; -.
DR OrthoDB; 1493146at2759; -.
DR PhylomeDB; O60739; -.
DR TreeFam; TF314417; -.
DR PathwayCommons; O60739; -.
DR SignaLink; O60739; -.
DR BioGRID-ORCS; 10289; 17 hits in 1080 CRISPR screens.
DR ChiTaRS; EIF1B; human.
DR GeneWiki; EIF1B; -.
DR GenomeRNAi; 10289; -.
DR Pharos; O60739; Tbio.
DR PRO; PR:O60739; -.
DR Proteomes; UP000005640; Chromosome 3.
DR RNAct; O60739; protein.
DR Bgee; ENSG00000114784; Expressed in heart right ventricle and 209 other tissues.
DR ExpressionAtlas; O60739; baseline and differential.
DR Genevisible; O60739; HS.
DR GO; GO:0016282; C:eukaryotic 43S preinitiation complex; IBA:GO_Central.
DR GO; GO:0043024; F:ribosomal small subunit binding; IBA:GO_Central.
DR GO; GO:0003723; F:RNA binding; HDA:UniProtKB.
DR GO; GO:0003743; F:translation initiation factor activity; IBA:GO_Central.
DR GO; GO:0006446; P:regulation of translational initiation; NAS:UniProtKB.
DR CDD; cd11566; eIF1_SUI1; 1.
DR InterPro; IPR001950; SUI1.
DR InterPro; IPR036877; SUI1_dom_sf.
DR InterPro; IPR005874; SUI1_euk.
DR Pfam; PF01253; SUI1; 1.
DR PIRSF; PIRSF004499; SUI1_euk; 1.
DR SUPFAM; SSF55159; SSF55159; 1.
DR TIGRFAMs; TIGR01160; SUI1_MOF2; 1.
DR PROSITE; PS50296; SUI1; 1.
PE 1: Evidence at protein level;
KW Acetylation; Initiation factor; Phosphoprotein; Protein biosynthesis;
KW Reference proteome.
FT INIT_MET 1
FT /note="Removed"
FT /evidence="ECO:0007744|PubMed:21406692"
FT CHAIN 2..113
FT /note="Eukaryotic translation initiation factor 1b"
FT /id="PRO_0000130558"
FT MOD_RES 2
FT /note="N-acetylserine"
FT /evidence="ECO:0007744|PubMed:21406692"
FT MOD_RES 9
FT /note="Phosphoserine"
FT /evidence="ECO:0007744|PubMed:21406692,
FT ECO:0007744|PubMed:23186163"
FT CONFLICT 27
FT /note="T -> L (in Ref. 1; AAC17112)"
FT /evidence="ECO:0000305"
FT CONFLICT 41
FT /note="R -> G (in Ref. 1; AAC17112)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 113 AA; 12824 MW; 4522A8B692654FE1 CRC64;
MSTIQNLQSF DPFADATKGD DLLPAGTEDY IHIRIQQRNG RKTLTTVQGI ADDYDKKKLV
KAFKKKFACN GTVIEHPEYG EVIQLQGDQR KNICQFLLEV GIVKEEQLKV HGF
