EIF1_MOUSE
ID EIF1_MOUSE Reviewed; 113 AA.
AC P48024; Q9WUD5;
DT 01-FEB-1996, integrated into UniProtKB/Swiss-Prot.
DT 30-MAY-2000, sequence version 2.
DT 03-AUG-2022, entry version 145.
DE RecName: Full=Eukaryotic translation initiation factor 1;
DE Short=eIF1;
DE AltName: Full=Protein translation factor SUI1 homolog;
GN Name=Eif1; Synonyms=Sui1, Sui1-rs1;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA].
RC TISSUE=Ureteric bud;
RA Li Z., Stuart R.O., Nigam S.K.;
RT "Differentially expressed genes in branching tubulogenesis.";
RL Submitted (FEB-1999) to the EMBL/GenBank/DDBJ databases.
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=C57BL/6J, and FVB/N; TISSUE=Brain, Colon, and Mammary tumor;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [3]
RP NUCLEOTIDE SEQUENCE [MRNA] OF 38-113.
RC STRAIN=DBA/2J;
RX PubMed=8903738; DOI=10.1007/pl00006936;
RA Purohit R., McCormick D., Dyson J.;
RT "Multiple translation initiation factor Sui1 related sequences in mammalian
RT genomes.";
RL Mamm. Genome 7:79-80(1996).
RN [4]
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC TISSUE=Brain, Brown adipose tissue, Kidney, Liver, Pancreas, Spleen, and
RC Testis;
RX PubMed=21183079; DOI=10.1016/j.cell.2010.12.001;
RA Huttlin E.L., Jedrychowski M.P., Elias J.E., Goswami T., Rad R.,
RA Beausoleil S.A., Villen J., Haas W., Sowa M.E., Gygi S.P.;
RT "A tissue-specific atlas of mouse protein phosphorylation and expression.";
RL Cell 143:1174-1189(2010).
CC -!- FUNCTION: Necessary for scanning and involved in initiation site
CC selection. Promotes the assembly of 48S ribosomal complexes at the
CC authentic initiation codon of a conventional capped mRNA (By
CC similarity). {ECO:0000250}.
CC -!- SUBUNIT: Interacts with RENT2. {ECO:0000250}.
CC -!- SIMILARITY: Belongs to the SUI1 family. {ECO:0000305}.
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DR EMBL; AF129888; AAD31266.1; -; mRNA.
DR EMBL; BC003463; AAH03463.1; -; mRNA.
DR EMBL; BC010791; AAH10791.1; -; mRNA.
DR EMBL; BC081429; AAH81429.1; -; mRNA.
DR EMBL; Z50159; CAA90519.1; -; mRNA.
DR CCDS; CCDS25417.1; -.
DR PIR; S58180; S58180.
DR RefSeq; NP_035638.1; NM_011508.2.
DR AlphaFoldDB; P48024; -.
DR BMRB; P48024; -.
DR SMR; P48024; -.
DR BioGRID; 203572; 10.
DR IntAct; P48024; 1.
DR STRING; 10090.ENSMUSP00000041538; -.
DR iPTMnet; P48024; -.
DR PhosphoSitePlus; P48024; -.
DR EPD; P48024; -.
DR jPOST; P48024; -.
DR PaxDb; P48024; -.
DR PeptideAtlas; P48024; -.
DR PRIDE; P48024; -.
DR ProteomicsDB; 277773; -.
DR Antibodypedia; 28894; 215 antibodies from 29 providers.
DR Ensembl; ENSMUST00000049385; ENSMUSP00000041538; ENSMUSG00000035530.
DR GeneID; 20918; -.
DR KEGG; mmu:20918; -.
DR UCSC; uc007lkv.1; mouse.
DR CTD; 10209; -.
DR MGI; MGI:105125; Eif1.
DR VEuPathDB; HostDB:ENSMUSG00000035530; -.
DR eggNOG; KOG1770; Eukaryota.
DR GeneTree; ENSGT00390000015789; -.
DR HOGENOM; CLU_082805_3_0_1; -.
DR InParanoid; P48024; -.
DR OMA; VENHIHI; -.
DR OrthoDB; 1493146at2759; -.
DR PhylomeDB; P48024; -.
DR TreeFam; TF314417; -.
DR BioGRID-ORCS; 20918; 16 hits in 40 CRISPR screens.
DR ChiTaRS; Eif1; mouse.
DR PRO; PR:P48024; -.
DR Proteomes; UP000000589; Chromosome 11.
DR RNAct; P48024; protein.
DR Bgee; ENSMUSG00000035530; Expressed in metanephric ureteric bud and 261 other tissues.
DR ExpressionAtlas; P48024; baseline and differential.
DR Genevisible; P48024; MM.
DR GO; GO:0005737; C:cytoplasm; ISO:MGI.
DR GO; GO:0016282; C:eukaryotic 43S preinitiation complex; IBA:GO_Central.
DR GO; GO:0005634; C:nucleus; ISO:MGI.
DR GO; GO:0043024; F:ribosomal small subunit binding; IBA:GO_Central.
DR GO; GO:0003723; F:RNA binding; IBA:GO_Central.
DR GO; GO:0003743; F:translation initiation factor activity; IBA:GO_Central.
DR GO; GO:0009048; P:dosage compensation by inactivation of X chromosome; IMP:MGI.
DR GO; GO:0006446; P:regulation of translational initiation; ISO:MGI.
DR CDD; cd11566; eIF1_SUI1; 1.
DR InterPro; IPR001950; SUI1.
DR InterPro; IPR036877; SUI1_dom_sf.
DR InterPro; IPR005874; SUI1_euk.
DR Pfam; PF01253; SUI1; 1.
DR PIRSF; PIRSF004499; SUI1_euk; 1.
DR SUPFAM; SSF55159; SSF55159; 1.
DR TIGRFAMs; TIGR01160; SUI1_MOF2; 1.
DR PROSITE; PS50296; SUI1; 1.
PE 1: Evidence at protein level;
KW Acetylation; Initiation factor; Phosphoprotein; Protein biosynthesis;
KW Reference proteome.
FT INIT_MET 1
FT /note="Removed"
FT /evidence="ECO:0000250|UniProtKB:P41567"
FT CHAIN 2..113
FT /note="Eukaryotic translation initiation factor 1"
FT /id="PRO_0000130555"
FT MOD_RES 2
FT /note="N-acetylserine"
FT /evidence="ECO:0000250|UniProtKB:P41567"
FT MOD_RES 2
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:P41567"
FT MOD_RES 9
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:P41567"
SQ SEQUENCE 113 AA; 12747 MW; 4B6C7F9B53FFEB34 CRC64;
MSAIQNLHSF DPFADASKGD DLLPAGTEDY IHIRIQQRNG RKTLTTVQGI ADDYDKKKLV
KAFKKKFACN GTVIEHPEYG EVIQLQGDQR KNICQFLIEI GLAKDDQLKV HGF
